Enzymatic crosslinking to fabricate antioxidant peptide-based supramolecular hydrogel for improving cutaneous wound healing

Wei, Qingcong; Duan, Jiaxin; Ma, Guang‐Lei; Zhang, Weiwei; Wang, Qigang; Hu, Zhiguo

doi:10.1039/c8tb03147a

Cited by 61 publications

(54 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a mouse study, the application of ointments containing FA and other plant extracts on induced burns modulated the inflammatory response and enhanced wound regeneration [ 134 ]. FA-supplemented hydrogels were recently developed to stimulate wound healing and reduce closure time, obtaining favorable outcomes in animal studies [ 135 , 136 ].…”

Section: Resultsmentioning

confidence: 99%

Potential Effects of Phenolic Compounds That Can Be Found in Olive Oil on Wound Healing

Melguizo‐Rodríguez

Luna-Bertos

Ramos‐Torrecillas

et al. 2021

Foods

View full text Add to dashboard Cite

The treatment of tissue damage produced by physical, chemical, or mechanical agents involves considerable direct and indirect costs to health care systems. Wound healing involves a series of molecular and cellular events aimed at repairing the defect in tissue integrity. These events can be favored by various natural agents, including the polyphenols in extra virgin olive oil (EVOO). The objective of this study was to review data on the potential effects of different phenolic compounds that can also be found in EVOO on wound healing and closure. Results of in vitro and animal studies demonstrate that polyphenols from different plant species, also present in EVOO, participate in different aspects of wound healing, accelerating this process through their anti-inflammatory, antioxidant, and antimicrobial properties and their stimulation of angiogenic activities required for granulation tissue formation and wound re-epithelialization. These results indicate the potential usefulness of EVOO phenolic compounds for wound treatment, either alone or in combination with other therapies. Human studies are warranted to verify this proposition.

show abstract

Section: Resultsmentioning

confidence: 99%

Potential Effects of Phenolic Compounds That Can Be Found in Olive Oil on Wound Healing

Melguizo‐Rodríguez

Luna-Bertos

Ramos‐Torrecillas

et al. 2021

Foods

View full text Add to dashboard Cite

show abstract

“…In this stage, collagen synthesis and collagen degradation take place continuously. Type III collagen degrades and replaces by type I collagen from the granulation tissue by metalloproteinase (MMPs) released from macrophages and fibroblasts (Wei et al, 2019). MMPs play an essential role in remodeling scar tissue by the reformation of the ECM.…”

Section: Tissue Remodelingmentioning

confidence: 99%

“…It is also called "Molecular self-assembly." Hydrogels formed by the supramolecular assembly has various biomedical applications such as tissue engineering (Saunders & Ma, 2019), wound healing (Wei et al, 2019;Xu et al, 2017;Yang et al, 2014). The rheological properties such as shear thinning kinetics and storage modulus determine the hydrogel's suitability for biomedical use.…”

Section: Supramolecular Injectable Hydrogels (Molecular Self-assembly)mentioning

confidence: 99%

Overview of in situ gelling injectable hydrogels for diabetic wounds

Mude

Sanapalli

Vadakkepushpakath

et al. 2021

Drug Development Research

View full text Add to dashboard Cite

Diabetes mellitus (DM) is an endocrine disorder that causes increased blood glucose than usual due to insulin impairment. In DM, several complications arise in which diabetic wound (DW) is the most devastating complication. About 25% of patients with DM expected to develop DWs in their lifetime and undergo limb amputations. Even though several treatments such as surgery, debridement, wound dressings, advanced therapies were available, the overall conclusion has been that with very few exceptions, patients still suffer from limitations like pain, frequent dress changing, high rates of failure, and cost involvement. Further, the treatments involving the delivery of therapeutic agents in treating DWs have limited success due to abnormal levels of proteases in the DW environment. In this backdrop, in situ gelling injectable hydrogels have gained special attention due to their easy encapsulation of therapeutic medications and prolonged release, filling the wound defect areas, ease of handling, and minimally invasive surgical procedures. Though the in situ gelling injectable hydrogels are developed a couple of decades ago, their use for treating DW has not yet been explored thoroughly. Thus, in this review, we have covered the sequential events of DW healing, pathophysiology, current treatments, and its limitations, along with a particular emphasis on the mechanism of action of these in situ gelling injectable hydrogels treating DWs.

show abstract

“…Peptide hydrogels have been successfully used in optoelectronic devices, 8 artificial catalysts, [9][10][11] templated synthesis of nanoparticles, 12,13 synthesis of nanohybrids, [14][15][16] waste water management [17][18][19] and oil spill recovery. 20,21 Current improvement of bio-medical technology demands gel-like soft materials for efficient culture of stem cells, 22 therapeutics, 23,24 immune modulation, 25 in vitro diagnostics, 26 wound healing, [27][28][29] creation of synthetic extracellular matrix, [30][31][32][33] anti-bacterial agents, [34][35][36][37][38] drug delivery [39][40][41] and many others. 42 For such applications, gel-forming peptides have great potential, due to their inherently biocompatible nature and low toxicity compared to conventional polymer-based materials.…”

Section: Introductionmentioning

confidence: 99%

Self-Assembling Peptide-Based Hydrogel: Regulation of Mechanical Stiffness and Thermal Stability and 3D Cell Culture of Fibroblasts

Bairagi

Biswas

Basu

et al. 2019

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

show abstract

Enzymatic crosslinking to fabricate antioxidant peptide-based supramolecular hydrogel for improving cutaneous wound healing

Abstract: We fabricated an antioxidant supramolecular hydrogel based on feruloyl-modified peptide and glycol chitosan by laccase-mediated crosslinking reaction, improving cutaneous wound healing.

Cited by 61 publications

References 32 publications

Potential Effects of Phenolic Compounds That Can Be Found in Olive Oil on Wound Healing

Potential Effects of Phenolic Compounds That Can Be Found in Olive Oil on Wound Healing

Overview of in situ gelling injectable hydrogels for diabetic wounds

Self-Assembling Peptide-Based Hydrogel: Regulation of Mechanical Stiffness and Thermal Stability and 3D Cell Culture of Fibroblasts

Contact Info

Product

Resources

About