“…1 H NMR (500 MHz, DMSO-d 6 ): δ 8.74 (t, J = 6.1 Hz, 1H), 8.45 (dd, J = 7.0, 2.4 Hz, 1H), 8.27 (s, 1H), 8.17−8.11 (m, 2H), 7.73 (dd, J = 10.9, 8.7 Hz, 1H), 7.35 (br s, 2H), 5.81 (d, J = 6.2 Hz, 1H), 5.49 (d, J = 6.2 Hz, 1H), 5.29 (d, J = 4.7 Hz, 1H), 4.65 (q, J = 6.0 Hz, 1H), 4.07 (td, J = 5.0, 3.2 Hz, 1H), 3.97 (td, J = 4.9, 3.2 Hz, 1H), 3.26−3.11 (m, 2H). 13 N-{[(2R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2yl]methyl}-4-bromo-3-nitrobenzenesulfonamide (12). Following method E with 41j (94 mg, 0.17 mmol, 1.00 equiv), 12 (54 mg, 62%) was obtained as a beige solid.…”