Enzymatic and antioxidant response of Lamellidens marginalis exposed to mercuric chloride

Pandey, Abhed; Singh, Avtar; Holeyappa, Shanthanagouda Admane; Kaur, Harsimranjit

doi:10.18805/ijar.b-3274

Cited by 4 publications

(4 citation statements)

References 23 publications

(24 reference statements)

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“…Mercury has a strong tendency to revive sulfur and especially thiol-like molecules such as glutathione (GSH), cysteine, and metallothionein. The toxic effects of mercury on organs such as the liver and kidneys are due to biological reactions with metallothionein, glutathione, and albumin [ 5 ]. Many studies showed that oxidative stress caused by mercury exposure (organic and inorganic) results from a reduction in thiol-containing groups, including glutathione.…”

Section: Introductionmentioning

confidence: 99%

The Antioxidant Effect of Medicago sativa L. (Alfalfa) Ethanolic Extract against Mercury Chloride (HgCl2) Toxicity in Rat Liver and Kidney: An In Vitro and In Vivo Study

Raeeszadeh

Moradi

Ayar

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Heavy metals such as mercury are some of the environmental pollutants and can induce toxicity by bioaccumulation and oxidative damage. This study aimed to investigate the effect of ethanolic extract of Medicago sativa L. (Alfalfa) on mercury damage in the kidney and liver of rats. Thirty Wistar rats were randomly divided into five groups, the control group, S group (2 mg/kg mercury chloride), and T1, T2, and T3 groups that, in addition to mercury, received doses of 250, 500, and 750 mg/kg of the alfalfa extract. On the last day, blood samples were taken, and the serum was separated to measure biochemical and oxidative stress parameters in the kidney and liver. A part of the kidney and liver was also used for histopathological evaluation. Total phenols and flavonoids were 40.45 ± 2.12 and 14.36 ± 0.45 mg/g, respectively, whereas IC50 was 245.18 ± 19.76 μg/ml. The body weight significantly decreased in the S group compared to other groups, while treatment with different doses of alfalfa extract increased the body weight. Mercury concentration in the kidney was higher than that in the liver. The serum levels of urea, creatinine, alanine aminotransferase (ALT), and alkaline phosphatase (ALP) significantly increased in the S group compared to the control group, while treatment with different doses of alfalfa extract increased their levels. Moreover, an increase in malondialdehyde (MDA) and a decrease in glutathione peroxidase (GPx), catalase (CAT), total antioxidant capacity (TAC), and superoxide dismutase (SOD) activity were observed in the S group. The level of these parameters significantly improved in the groups receiving the extract compared to the S group. Furthermore, the histopathological evaluation showed glomerular and tubular damage and hepatic necrosis in the S group and that these conditions improved in the T3 group. The findings of this study showed that the ethanolic extract of alfalfa in a dose-dependent manner has potentially unique protective effects against mercury poisoning in the kidney and liver.

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Section: Introductionmentioning

confidence: 99%

The Antioxidant Effect of Medicago sativa L. (Alfalfa) Ethanolic Extract against Mercury Chloride (HgCl2) Toxicity in Rat Liver and Kidney: An In Vitro and In Vivo Study

Raeeszadeh

Moradi

Ayar

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Some previous studies showed that heavy metals can influence the LDH activity. For example, Pandy et al found that mercury exposure can reduce the LDH activity in gill of L. marginailis [54]. Akintunde et al found that LDH activity in rat can be reduced by mixed-metal exposure, including Pd, Cd, Co, and Cr [55].…”

Section: Discussionmentioning

confidence: 99%

Ecotoxicological Effect of Single and Combined Exposure of Carbamazepine and Cadmium on Female Danio rerio: A Multibiomarker Study

Shi

Liu

et al. 2019

Applied Sciences

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In aquatic environments, organisms are exposed to mixtures of pollutants which may change the toxicity profile of each contaminant, compared to its toxicity alone. Carbamazepine (CBZ) and cadmium (Cd) are among the pollutants that co-occur in aquatic environments. To date, most research about their toxicity towards aquatic vertebrates is based on single exposure experiments. The present study aims to evaluate single and combined effects of CBZ and Cd on biomarkers in female Danio rerio (zebrafish) by exposing them to environmentally relevant concentrations of these two pollutants for ten days. Four kinds of biomarkers involved in antioxidant systems, energy metabolism, nervous system, and endocrine disruption, respectively, were studied. Our research results coincided with those of former studies in single exposure experiments. However, the combined exposure of CBZ and Cd exerted different responses from other studies in which these two contaminants were examined alone in zebrafish. The present study evidenced the need to conduct more coexposure studies to enhance the environmental relevance of these experimental results.

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“…The acute toxicity was studied in fat head minnows (4 mg/lit) by Linda Little [36] . The cytotoxicity was studied in rat L6 cell [42] . From the past few decades, many species have been used as biomonitoring organisms as per their potential.…”

Section: Introductionmentioning

confidence: 99%

Toxicological assessments of basic blue 3 dye in fresh water bivalve Lamellidens marginalis

Rupali,

Tejas,

Dipak

2024

Int. J. Fish. Aquat. Stud.

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The Basic blue 3 dye is a cationic dye gives colour shading from blue to green by addition with different chemicals. The acute exposure of this dye for 96 hours to bivalves showed altered physiological parameters. Increased level of antioxidant enzymes in gill, hepatopancreas, gonad and mantle of bivalve was recorded. At 70 ppm concentration of Basic blue 3 dye showed significant increase in gill and hepatopancreas while non-significant increase in gonad and mantle. At both the concentration 40 ppm and 70 ppm of the dye gives structural changes in gill, hepatopancreas and gonad assessed by histology. In gill, the structural changes were Swollen gill lamellae, ruptured epithelial cells, disorganization of gill filament and cell necrosis noticed; the hepatopancreas showed the abnormal shape of digestive tubules, destruction of digestive cells, mixing of cellular content of tubules, damages at basement membrane and degeneration of connective tissue while in gonad Stages of oocytes showed degenerative changes, the vacuolization in oocytes, degeneration of oolemma and ooplasm was observed. By comet assay tail DNA% and tail moment was recorded. At 70 ppm concentration, the gill cells showed significant tail DNA% and tail moment.

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Enzymatic and antioxidant response of Lamellidens marginalis exposed to mercuric chloride

Cited by 4 publications

References 23 publications

The Antioxidant Effect of Medicago sativa L. (Alfalfa) Ethanolic Extract against Mercury Chloride (HgCl2) Toxicity in Rat Liver and Kidney: An In Vitro and In Vivo Study

The Antioxidant Effect of Medicago sativa L. (Alfalfa) Ethanolic Extract against Mercury Chloride (HgCl2) Toxicity in Rat Liver and Kidney: An In Vitro and In Vivo Study

Ecotoxicological Effect of Single and Combined Exposure of Carbamazepine and Cadmium on Female Danio rerio: A Multibiomarker Study

Toxicological assessments of basic blue 3 dye in fresh water bivalve Lamellidens marginalis

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