Enzootic Intranasal Tumour of Goats in Italy

Vitellozzi, G.; Mughetti, L.; Palmarini, Massimo; Mandara, Maria Teresa; Mechelli, Luca; Sharp, JM; Manocchio, I

doi:10.1111/j.1439-0450.1993.tb00164.x

Cited by 23 publications

(30 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In goats, tumors seem to be less frequent, although some cases of EIT have been reported in recent years. 4,5,10,14,17,23 The enzootic intranasal tumor is a chronic and afebrile disease characterized by a profuse initial seromucous and then purulent nasal exudate associated with clinical signs of respiratory distress. In the late period of the disease, facial swelling, sometimes with seromucous exudation, is found because of nasal bone erosion and skin ulceration.…”

Section: Origin Of Enzootic Intranasal Tumor In the Goat (Capra Hircumentioning

confidence: 99%

“…5,6,11,23 After numerous etiologic hypotheses, from environmental to genetic factors, a viral cause was demonstrated. Viral-like particles, compatible with a type D retrovirus, were isolated from nasal fluid, and neoplastic tissue and successful experimental transmission of EIT from goat to goat confirmed this hypothesis.…”

Section: Origin Of Enzootic Intranasal Tumor In the Goat (Capra Hircumentioning

confidence: 99%

See 1 more Smart Citation

Origin of Enzootic Intranasal Tumor in the Goat (Capra hircus): A Glycohistochemical Approach

et al. 2001

Self Cite

View full text Add to dashboard Cite

Abstract. Enzootic intranasal tumor (EIT) appears glandular in type and has recently been classified as an adenocarcinoma of low malignancy. The aim of this study was to characterize the secretion of surface glycoconjugates (GCs) in EIT and in normal respiratory and olfactory mucosae of the goat by means of conventional and lectin histochemistry, in order to shed light on the histogenesis of EIT. Morphologic and ultrastructural investigations showed two growth types of EIT: i.e., tubular and papillary patterns. Conventional histochemistry revealed the presence of neutral and carboxylated GCs in the olfactory glands and in the tubular part of EIT, as well neutral and sulphated GCs in the respiratory glands and in the papillary part of EIT, suggesting that the papillary pattern tumor arises from the respiratory glands, whereas the tubular portion of EIT arises from the olfactory glands. Lectin histochemistry gave further information on the expressed GCs.

show abstract

Section: Origin Of Enzootic Intranasal Tumor In the Goat (Capra Hircumentioning

confidence: 99%

Section: Origin Of Enzootic Intranasal Tumor In the Goat (Capra Hircumentioning

confidence: 99%

Origin of Enzootic Intranasal Tumor in the Goat (Capra hircus): A Glycohistochemical Approach

et al. 2001

Self Cite

View full text Add to dashboard Cite

show abstract

“…The gross pathology and histology of ENA in sheep and goats appear to be identical (De las Heras et al, 2003). The association between ENA and enzootic nasal tumour virus (ENTV) is well established (Cousens et al, , 1999De las Heras et al, 1991a, b, 1993Vitelozzi et al, 1993), although less well characterized than the relationship between OPA and jaagsiekte sheep retrovirus (JSRV) (Palmarini et al, 1999). These viruses are closely related to each other and to sheep endogenous retroviral sequences (ovERVs) at the nucleic acid level (Hecht et al, 1994;Cousens et al, 1996Cousens et al, , 1999.…”

Section: Introductionmentioning

confidence: 99%

Characterization of enzootic nasal tumour virus of goats: complete sequence and tissue distribution

Ortı́n

Cousens

Minguijón

et al. 2003

Journal of General Virology

View full text Add to dashboard Cite

The complete genome sequence of a new isolate of enzootic nasal tumour virus (ENTV-2), associated with enzootic nasal adenocarcinoma (ENA) of goats, was determined. The genome exhibits a genetic organization characteristic of b-retroviruses. ENTV-2 is closely related to the retrovirus (ENTV-1) associated with enzootic adenocarcinoma of sheep, and to jaagsiekte retrovirus. The main sequence differences between these viruses reside in orfX, the U3 LTR, two small regions in gag and the transmembrane (TM) region of env. Sequence analysis of the TM region of env from several sheep and goats naturally affected by ENA suggested that ENTV-1 and ENTV-2 are distinct viruses rather than geographical variants. Although both viruses transform secretory epithelial cells of the ethmoid turbinate, the study of their tissue distribution using specific PCRs showed that ENTV-2 establishes a disseminated lymphoid infection whereas ENTV-1 is mainly confined to the tumour.

show abstract

“…ENTV can be found in the nasal fluid of animals with intranasal tumors, which eventually progress and cause severe cranial deformations and respiratory blockage, resulting in death (41). ENTV is closely related to jaagsiekte sheep retrovirus (JSRV) (Ͼ95% overall amino acid similarity) (4), which is the causative agent of ovine pulmonary adenocarcinoma (also called sheep pulmonary adenomatosis or jaagsiekte) (30).…”

mentioning

confidence: 99%

Mechanism of Cell Entry and Transformation by Enzootic Nasal Tumor Virus

Dirks

Duh

Sharath³

et al. 2002

J Virol

View full text Add to dashboard Cite

Enzootic nasal tumor virus (ENTV) induces nasal epithelial cancer in infected sheep, but it is a simple retrovirus lacking a known oncogene. ENTV is closely related to jaagsiekte sheep retrovirus (JSRV), which also causes cancer in sheep but in the epithelial cells of the lower airways and alveoli. Here we show that as with JSRV, the envelope (Env) protein of ENTV can transform cultured cells and thus is likely to be responsible for oncogenesis in animals. In addition, the ENTV Env protein mediates virus entry using the same receptor as does JSRV Env, the candidate tumor suppressor Hyal2. However, ENTV Env mediates entry into cells from a more restricted range of species than does JSRV, and based on this finding we have identified amino acid regions in the Env proteins that are important for virus entry. Also, because ENTV does not efficiently use human Hyal2 as a receptor, we cloned the ovine Hyal2 cDNA and show that the encoded protein functions as an efficient receptor for both ENTV and JSRV. In summary, although ENTV and JSRV use the same cell surface receptor for cell entry and apparently transform cells by the same mechanism, they induce cancer in different tissues of infected sheep, indicating that oncogenesis is regulated at some other level. The transcriptional regulatory elements in these viruses are quite different, indicating that tissue-specific oncogenesis is likely regulated at the level of viral gene expression. Enzootic nasal tumor virus (ENTV) is a simple retrovirusthat is transmitted horizontally and induces nasal adenocarcinoma in sheep (4, 10) and goats (8, 9). ENTV can be found in the nasal fluid of animals with intranasal tumors, which eventually progress and cause severe cranial deformations and respiratory blockage, resulting in death (41). ENTV is closely related to jaagsiekte sheep retrovirus (JSRV) (Ͼ95% overall amino acid similarity) (4), which is the causative agent of ovine pulmonary adenocarcinoma (also called sheep pulmonary adenomatosis or jaagsiekte) (30). Unlike tumors caused by ENTV, which arise from nasal epithelial cells, JSRV-induced tumors arise from epithelial cells in the lower airway, including type II alveolar and bronchiolar epithelial cells (27). The mechanism of oncogenesis by ENTV and its relationship to that caused by JSRV are unknown. Both of these viruses are present in many countries worldwide and have a significant economic and animal health impact. In addition, the disease induced by JSRV exhibits histological features similar to those of many human pulmonary adenocarcinomas, including bronchioloalveolar carcinoma (28, 33). Thus, study of adenocarcinoma induced by JSRV and ENTV may provide insights into the etiology of human lung cancer. While ENTV and JSRV do not appear to cause lung cancer in humans having occupational exposure to these viruses, a recent study shows that antiserum directed against the JSRV capsid protein cross-reacts with 30% of human pulmonary adenocarcinoma samples but not with nontumorous lung lesions, normal lung tissue, or many adenoc...

show abstract

Enzootic Intranasal Tumour of Goats in Italy

Cited by 23 publications

References 8 publications

Origin of Enzootic Intranasal Tumor in the Goat (Capra hircus): A Glycohistochemical Approach

Origin of Enzootic Intranasal Tumor in the Goat (Capra hircus): A Glycohistochemical Approach

Characterization of enzootic nasal tumour virus of goats: complete sequence and tissue distribution

Mechanism of Cell Entry and Transformation by Enzootic Nasal Tumor Virus

Contact Info

Product

Resources

About