Environmentally-realistic concentration of cadmium combined with polyunsaturated fatty acids enriched diets modulated non-specific immunity in rainbow trout

Applying a multiscale systems biology approach to study the effect of chronic low-dose exposure to uranium in rat kidneys

“…Among these pathways, several have already been described as biomarkers of oxidative stress after exposure to copper (Taylor et al 2009) and long-term exposure to heavy metals (Sarma et al 2018). Moreover, fatty acids have been described as one of the most important biomarkers of chemical stressors such as heavy metals (Filimonova et al 2016); they are associated with oxidative stress (Reglero et al 2009) and closely linked to the inflammatory immune response (Cornet et al 2018) (Figure 1). These pathways indicate the broad effect of uranium through inter-network relations between metabolic pathways and possible physiological consequences.…”

Total replacement of fish meal by enriched‐fatty acidHermetia illucensmeal did not substantially affect growth parameters or innate immune status and improved whole body biochemical quality of Nile tilapia juveniles

“…The lack of positive effects of dietary supplementation in PUFAs or LC‐PUFAs on growth could be due to the differences in the doses used or to the interference with the high endogenous hability of the latter species for LC‐PUFAS biosynthesis. In salmonids such as rainbow trout, it has been reported that a DHA‐enriched diet improved the growth performance of juvenile compared to a diet enriched with ALA (Cornet et al, 2018).…”

Fatty acid composition, osmolality, Na + , K + ‐ATPase activity, cortisol content and antioxidant status of rainbow trout ( Oncorhynchus mykiss ) in response to various dietary levels of eicosapentaenoic acid and docosahexaenoic acid

“…The fatty acid composition of cellular membranes can modify permeability (Imen et al, 2013;Palacios, Bonilla, Perez, Racotta, & Civera, 2004). Huster, Jin, Arnold, and Gawrisch (1997), Hishikawa, Valentine, Iizuka-Hishikawa, Shindou, and Shimizu (2017), and Cornet et al (2018) reported that high levels of PUFA, such as DHA, could make membranes thin, flexible and fluid, while Morris, Lockwood, and Dawson (1982) reported the possible relationship between decreased permeability and increased SFA in the gills of amphipod crustaceans (Gammarus duebeni). From another point of view, the accumulation of n-3 PUFA, especially EPA and DHA, can alter the membrane microenvironment and thereby enhance NKA activity (Bell et al, 1997;Bystriansky & Ballantyne, 2007;Grant et al, 2008 It is generally believed that when external salinity is altered, the response of serum osmolality in teleost fish can be divided into two stages: first, a passive increase or decrease in serum osmolality occurs depending on the environment; second, osmolality begins to recover through physiological regulation and remains stable (Sturrock, Hunter, Milton, & Trueman, 2013;Zhu et al, 2018).…”

“…The fatty acid composition of cellular membranes can modify permeability (Imen et al, 2013; Palacios, Bonilla, Perez, Racotta, & Civera, 2004). Huster, Jin, Arnold, and Gawrisch (1997), Hishikawa, Valentine, Iizuka‐Hishikawa, Shindou, and Shimizu (2017), and Cornet et al (2018) reported that high levels of PUFA, such as DHA, could make membranes thin, flexible and fluid, while Morris, Lockwood, and Dawson (1982) reported the possible relationship between decreased permeability and increased SFA in the gills of amphipod crustaceans ( Gammarus duebeni ). From another point of view, the accumulation of n‐3 PUFA, especially EPA and DHA, can alter the membrane microenvironment and thereby enhance NKA activity (Bell et al, 1997; Bystriansky & Ballantyne, 2007; Grant et al, 2008).…”