Environmentally friendly stability-indicating HPLC method for the determination of isotretinoin in commercial products and solubility samples

Haq, Nazrul; Alshehri, Sultan; Alsarra, Ibrahim A.; Alenazi, Miteb; Alwhaibi, Abdulrahman; Shakeel, Faiyaz

doi:10.1016/j.heliyon.2023.e18405

Cited by 4 publications

(3 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These peaks represent different variants of the hydrolyzed gelatin molecules. Peak 6 was the most prominent peak, indicating that it represents the most abundant variant of hydrolyzed gelatin in the samples analyzed. − This protocol demonstrates a refined chromatographic method for purifying hydrolyzed gelatin. The method utilizes a low TFA mobile phase for improved peak resolution and identifies specific peaks corresponding to different hydrolyzed gelatin variants.…”

Section: Resultsmentioning

confidence: 92%

Fabrication of Highly Transparent Substrates from Waste Materials for Electronic Device Applications

Guhathakurata,

Pal,

Reddy

et al. 2024

ACS Appl. Electron. Mater.

View full text Add to dashboard Cite

In recent years, organic electronics have been explored as a potential paradigm for renewable, transient, and biodegradable systems. In this study, we used fish scales as raw materials for fabricating a biopolymer substrate (BPS) and evaluated its application in an organic metal−insulator−metal capacitor. Evaluation of the morphological and optical properties of BPS revealed an average surface roughness value of 1.19 nm, 90% transmittance in the UV− visible range, and an absorption coefficient of 5.29 cm −1 at 3.5 eV. Fourier transform infrared spectroscopy showed the presence of amide A, amide I, amide II, and amide III bonds in the substrate, and 42°± 5°was the rollover contact angle. The substrate was dissolved in water within 40 min at room temperature and degraded by more than 90% within 30 days in natural soil. Further, mechanical property analysis showed that the substrate exhibited a flexural strength of 8.33 MPa and a tensile strength of 4 MPa. The capacitance density and leakage current of the Al/bovine serum albumin/Pt/BPS structure are found to be 1.05 fF/μm 2 (1 MHz, 1 V) and 1.15 μA/cm 2 (at 1 V), respectively. The proposed substrate can be used as a cost-efficient, ecofriendly, biocompatible, and transparent charge storage device for transient electronics in the near future.

show abstract

Section: Resultsmentioning

confidence: 92%

Fabrication of Highly Transparent Substrates from Waste Materials for Electronic Device Applications

Guhathakurata,

Pal,

Reddy

et al. 2024

ACS Appl. Electron. Mater.

View full text Add to dashboard Cite

show abstract

“…The Analytical GREEnness (AGREE) score was determined to evaluate the eco-friendliness nature of the HPLC method. The AGREE score was predicted to be 0.76 for the present HPLC method, indicating the eco-friendly nature of the HPLC method [53]. ITN mole fraction solubilities (x e ) were calculated using their standard formulae described in our previous work [38][39][40].…”

Section: Determination Of Itn (3) Solubility In {Dmso (1) + H 2 O (2)...mentioning

confidence: 89%

“…The saturated solutions were again removed from the shaker after they had reached equilibrium and centrifuged for 30 min at 5000 rpm. A previously established environmentally friendly HPLC method was used to assess the ITN content after the supernatants were isolated and diluted (as required) [53]. The identification of ITN was carried out via a Nucleodur (dimensions: 150 mm × 4.6 mm and particle size: 5 µm) reversed-phase C 18 analytical column at 298.2 K. The environmentally friendly mobile used was a binary mixture of ethyl acetate and ethanol (50:50% v v −1 ).…”

Section: Determination Of Itn (3) Solubility In {Dmso (1) + H 2 O (2)...mentioning

confidence: 99%

Solubility and Thermodynamic Analysis of Isotretinoin in Different (DMSO + Water) Mixtures

Shakeel,

Haq,

Alshehri

et al. 2023

Molecules

Self Cite

View full text Add to dashboard Cite

The solubility and solution thermodynamics of isotretinoin (ITN) (3) in numerous {dimethyl sulfoxide (DMSO) (1) + water (H2O) (2)} combinations were studied at 298.2–318.2 K under fixed atmospheric pressure of 101.1 kPa. A shake flask methodology was used to determine ITN solubility, and correlations were made using the “van’t Hoff, Apelblat, Buchowski-Ksiazczak λh, Yalkowsky-Roseman, Jouyban-Acree, and Jouyban-Acree-van’t Hoff models”. In mixtures of {(DMSO (1) + H2O (2)}, the solubility of ITN in mole fractions was enhanced with the temperature and DMSO mass fraction. The mole fraction solubility of ITN was highest in neat DMSO (1.02 × 10−1 at 318.2 K) and lowest in pure H2O (3.14 × 10−7 at 298.2 K). The output of computational models revealed good relationships between the solubility data from the experiments. The dissolution of ITN was “endothermic and entropy-driven” in all of the {(DMSO (1) + H2O (2)} mixtures examined, according to the positive values of measured thermodynamic parameters. Enthalpy was discovered to be the driving force behind ITN solvation in {(DMSO (1) + H2O (2)} combinations. ITN-DMSO displayed the highest molecular interactions when compared to ITN-H2O. The outcomes of this study suggest that DMSO has a great potential for solubilizing ITN in H2O.

show abstract

Analysis of the greenness to determine risperidone in commercial products using a green stability-indicating HPTLC method

Alam,

Shakeel,

Alshehri

et al. 2024

Arabian Journal of Chemistry

View full text Add to dashboard Cite

Environmentally friendly stability-indicating HPLC method for the determination of isotretinoin in commercial products and solubility samples

Cited by 4 publications

References 46 publications

Fabrication of Highly Transparent Substrates from Waste Materials for Electronic Device Applications

Fabrication of Highly Transparent Substrates from Waste Materials for Electronic Device Applications

Solubility and Thermodynamic Analysis of Isotretinoin in Different (DMSO + Water) Mixtures

Analysis of the greenness to determine risperidone in commercial products using a green stability-indicating HPTLC method

Contact Info

Product

Resources

About