A rapid
nanoconfined liquid phase filtration system (NLPF) based
on solvent-confined carbon nanofibers/carbon fiber materials (CNFs/CFs)
was proposed to effectively remove chlorinated pesticides from ginsenosides-containing
ginseng extracts. A series of major parameters that may affect the
separation performance of the CNFs-NLPF method were extensively investigated,
including the water solubility of nanoconfined solvents, filtration
rate, ethanol content of the ginseng extracts, and reusability of
the material for repeated adsorption. The developed method showed
a high removal efficiency of pesticides (85.5–97.5%), high
retainment rate of ginsenosides (95.4–98.9%), and consistent
reproducibility (RSD < 11.8%). Furthermore, the feasibility of
the CNFs-NLPF technique to be scaled-up for industrial application
was systematically explored by analyzing large-volume ginseng extract
(1 L), which also verified its excellent modifiable characteristic.
This filtration method exhibits promising potential as a practical
tool for removing pesticide residues and other organic pollutants
in food samples to assure food quality and safeguard human health.