Environmentally Benign One-Pot Synthesis of Cyanamides from Dithiocarbamates Using I2 and H2O2

Jamir, Latonglila; Sinha, Upasana Bora; Nath, Jayashree; Patel, Bhisma K.

doi:10.1080/00397911.2010.532276

Cited by 32 publications

(10 citation statements)

References 24 publications

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“…Organic dithiocarbamates have been extensively used as intermediate for the synthesis of structurally diverse synthetic intermediates/molecules of biological significance like antimalarial [11], anticholinergic [12], antimicrobial [13], antimitotic [14], antitubercular [15], antifungal [16], anticancer [17], antioxidant [18], antiprotozoal [19], antileprosy [20], antifolates [21], antitubulin [22], antialzheimer [23], anti-HIV [24], antipoliferative [25] and anticontraceptives [26] active agents. As a useful synthon organic dithiocarbamates have been extensively used for the synthesis of structurally diverse biological potent synthetic intermediates/molecules like isothiocyanates [27], thiourea [28], cynamide [29], dithiobenzophene [30], glycosides [31], β-sulphonamides [32], amide [33], dicarboxylates [34], thiadizoles [35], dithiolanes [36], and anhyd. K 2 CO 3 (10 eqv.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antimicrobial Activity of Dithiocarbamates of ω-Substituted (2-naphthyloxy)alkanes

et al. 2019

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A series of dithiocarbamates of ω-substituted (2-naphthyloxy) alkanes was developed through condensation of 2-(2-chloro-alkoxy)naphthalene to various kinds of aliphatic, aromatic, alicyclic, heterocyclic primary and secondary amines employing benzyl trimethyl ammonium hydroxide in catalytic quantity (Triton-B/CS2 system) afforded desired products in high yields (82-98 %). The complete series of synthesized compounds (4-48) were evaluated for antimicrobial activity through microdilution method using various bacterial and fungal strains. The antifungal and antibacterial values were estimated as MIC values. Fluconazole and ciprofloxacin [16 to 0.03 µg/ mL] were used as the standard antifungal and antibacterial drug, respectively. Out of series of evaluated compounds, some of these compounds such as compounds 28, 29, 30, 31, 32, 33 have displayed maximum potency which is comparable to standard drugs.This is an open access journal, and articles are distributed under the terms of the Attribution 4.0 International (CC BY 4.0) License. This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit the author for the original creation. You must give appropriate credit, provide a link to the license, and indicate if changes were made. thiones [37], benzimidazole [38], carbamate [39], pyran [40] and flavonoids [41], etc. Apart from above mentioned activities, dithiocarba-mates of various imidazole [42], brassinin [43], rhodanine [44], quinoline [45], metal complexes [46], ammonium salts [47], etc. derivative have emerged as potent antimicrobial agents. As our group is working in drug discovery through design and synthesis of novel class of natural/semi-synthetic/ synthetic molecules especially molecules like carbamates, dithiocarbamates, dithiocarbazates, etc.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Antimicrobial Activity of Dithiocarbamates of ω-Substituted (2-naphthyloxy)alkanes

et al. 2019

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“…Furthermore, it has been comprehended through a number of available reports that biological activities of molecules increase diversely by incorporating dithiocarbamate moiety into it [22]. Organic dithiocarbamates have been used as the synthon for various synthesis [23][24][25][26][27][28][29][30][31][32] etc. and considered as the important biological moiety.…”

Section: Introductionmentioning

confidence: 99%

Novel Synthetic Strategy of Cyclic Dithiocarbamates Catalyzed by Triton-B

et al. 2019

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A simple, rapid and green methodology to synthesize cyclic dithiocarbamates (compounds 1-9) was developed by the reaction of 1° amines, CS2 and ethyl 3-bromo-2-oxopropanoate (ethyl bromopyruvate) facilitated by Triton-B as phase transfer catalyst. These compounds (1-9) were characterized with the help of elemental analysis, IR, NMR and mass spectroscopic methods This efficient green approach requires mild conditions and gives good yield of product. In vitro antimicrobial activities of these compounds are reported against the pathogenic bacteria and fungi.

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“…[11,12] Additionally, 2-(alkylthio)thiazol-4(5H)-ones are efficient intermediates for the synthesis of 2-aminothiazol-4(5H)-ones, which are an important category of biologically active compounds. [12][13][14][15] Dithiocarbamates are versatile synthetic intermediates which have been extensively applied for the preparation of thioureas, [16] isothiocyanates, [17] 2-imino-1,3-dithiolanes, [18] cyanamides, [19] heterocyclic rings, [20][21][22][23] the protection of aldehydes, [24] amide bond formation [25] and protection of amino groups in peptide synthesis. [26] In addition to their synthetic utility, these compounds also have found wide application in agriculture, [27,28] medicine [29,30] and coordination chemistry.…”

Section: Introductionmentioning

confidence: 99%

Dithiocarbamate as an efficient intermediate for the synthesis of 2-(alkylthio)thiazol-4(5H)-ones

Halimehjani

Alaei

Movahed

et al. 2016

Journal of Sulfur Chemistry

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Environmentally Benign One-Pot Synthesis of Cyanamides from Dithiocarbamates Using I₂ and H₂O₂

Cited by 32 publications

References 24 publications

Synthesis and Antimicrobial Activity of Dithiocarbamates of ω-Substituted (2-naphthyloxy)alkanes

Synthesis and Antimicrobial Activity of Dithiocarbamates of ω-Substituted (2-naphthyloxy)alkanes

Novel Synthetic Strategy of Cyclic Dithiocarbamates Catalyzed by Triton-B

Dithiocarbamate as an efficient intermediate for the synthesis of 2-(alkylthio)thiazol-4(5H)-ones

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