Environmentally Benign, Highly Efficient and Expeditious Solvent‐Free Synthesis of Trisubstituted Methanes Catalyzed by Sulfated Polyborate

Abstract

Highly efficient and environmental friendly one‐pot synthesis of trisubstituted methanes form aldehydes and heteroaryls with sulfated polyborate catalyst was conveniently performed under solvent‐free grinding condition at room temperature. The catalyst is recyclable up to five consecutive runs and column chromatography‐free isolation of the trisubstituted methanes in excellent yields was achieved.

Chitosan hydrochloride mediated efficient, green catalysis for the synthesis of perimidine derivatives

“…The filtrate was allowed to dry and recycled five times without any significant loss in weight and activity giving yields more than 85% (Figure ). We have also calculated the green chemistry matrices as reported earlier in our lab by Jejurkar et al The reaction has atom economy (AE) of 93.52%, reaction mass efficiency (RME) is 96%, E‐factors value of 0.041 21, and the eco‐scale score for the method is 80 (Figure ).…”

Synthesis and Evaluation of Anticancer Activity of Pyrazolone Appended Triarylmethanes (TRAMs)

“…[38][39][40] Analysis and review of small molecules based on TRAM with potent anticancer activities has prompted us to design a pyrazolone ring containing triarylmethanes which aligns with our ongoing research project on designing and developing bioactive molecules as well as molecules for applications in biology. [41][42][43][44][45][46][47][48][49] It was interesting to note that several compounds are known in the literature, that possess a triphenylmethyl motif, appear to be potent anticancer agents. We, therefore, created a series of pyrazolone-appended hetero triarylmethane scaffolds.…”

“…Analysis and review of small molecules based on TRAM with potent anticancer activities has prompted us to design a pyrazolone ring containing triarylmethanes which aligns with our ongoing research project on designing and developing bioactive molecules as well as molecules for applications in biology [41–49] …”

Humic acid: A Biodegradable Organocatalyst for Solvent‐free Synthesis of Bis(indolyl)methanes, Bis(pyrazolyl)methanes, Bis‐coumarins and Bis‐lawsones

“… [20] The widely used protocol to design this important molecule is very straightforward and it can easily obtained by the reaction between aldehydes and indole following the Friedel‐Craft alkylation type pathway. A few protocols are reported in literature using various catalyst and solvent such as enzymes, [21] meglumine, [22] thiamine hydrochloride, [23] graphene oxide, [24] ethyl lactate, [25] sulphated polyborate, [26] Lewis acids, [27–32] Brønsted acids, [33] heteropoly acids, [34–36] solid acids, [37–42] ionic liquids, [43] metal complexes, [44–46] 4‐sulfophthalic acid [47] and Iodine/tert‐Butyl Hydroperoxide [48] . Recently, a number of methodologies have been developed in this field [49–68] .…”