Environmental toxins and Alzheimer's disease progression

Vasefi, Maryam; Ghaboolian-Zare, Ehsan; Abedelwahab, Hamzah; Osu, Anthony

doi:10.1016/j.neuint.2020.104852

Cited by 25 publications

(15 citation statements)

References 175 publications

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“…Aging, genetic and environmental factors play important roles in the onset of a wide range of chronic, metabolic, and neurodegenerative diseases [1]. Age-related disability and morbidity influence the quality of life; they are ultimately associated with an increased risk of death and serious consequences for the individual and society.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Biological Evaluation of Halogenated E-Stilbenols as Promising Antiaging Agents

et al. 2020

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The increased risk of illness and disability is related to the age inevitable biological changes. Oxidative stress is a proposed mechanism for many age-related diseases. The crucial importance of polyphenol pharmacophore for aging process is largely described thanks to its effects on concentrations of reactive oxygen species. Resveratrol (3,5,4′-trihydroxy-trans-stilbene, RSV) plays a critical role in slowing the aging process but has a poor bioavailabity after oral intake. In this present work, a series of RSV derivatives was designed, synthesized, and evaluated as potential antioxidant agents. These derivatives contain substituents with different electronic and steric properties in different positions of aromatic rings. This kind of substituents affects the activity and the bioavailability of these compounds compared with RSV used as reference compound. Studies of Log P values demonstrated that the introduction of halogens gives the optimum lipophilicity to be considered promising active agents. Among them, compound 6 showed the higher antioxidant activity than RSV. The presence of trifluoromethyl group together with a chlorine atom increased the antioxidant activity compared to RSV.

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Section: Introductionmentioning

confidence: 99%

“…Dose-response effects of compounds(1)(2)(3)(4)(5)(6)(7) and RSV in C2C12 cells after 24 h. MTT reduction assay in C2C12 cells in the presence of (1-7) together with RSV. The cells were incubated with increasing concentrations of the compounds (1, 10, 100 µM) for 24 h. After this period, cell viability was quantified by measuring MTT reduction.…”

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confidence: 99%

Synthesis and Biological Evaluation of Halogenated E-Stilbenols as Promising Antiaging Agents

et al. 2020

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“…Paclitaxel, Epothilone, D-NAP(NAPVSIPQ), and D-SAL(SALLRSIPA). Drugs (Astemizole, Lansoprazole, and methylthioninechloride) have a strong affinity for tau protein indirectly to reduce tau-tau interaction by blocking the tau oligomerization [40]. Heat shock protein 90 (Hsp 90), folds denatured-proteins aids in preventing tau degradation.…”

Section: Tau Protein Targetingmentioning

confidence: 99%

Alzheimer’s Disease: Perspective on Therapeutic Options and Recent Hallmarks in Clinical Research

Beera¹,

Seethamraju²,

Nori³

2021

Int j pharm res allied sci

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Alzheimer's disease (AD) is a progressive neurodegenerative, a primarily concerned and leading cause of mortality worldwide which has no cure so far, of the world. The disease progresses from memory loss to cognitive decline gradually. The severity of Alzheimer's grows up from mild, moderate to severe. Hallmarks of the research of AD reported, are the identification of amyloid-beta (Aβ) plaques and tau protein tangles between and within the neuronal cells, oxidative stress, low acetylcholine, and most importantly the genetic connection. Diagnosis of this condition is not so simple since there is no single test that identifies Alzheimer's as early as possible. The therapies for the disease just provide symptomatic relief but not cure. The present review emphasizes the disease burden in the world, neurobiological aspects, and its management through conventional drug therapies along with novel research on therapeutic strategies, new drugs which showed excellent results that are to be approved and were approved, including investigations on plant medicine.

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“…After years of research, scientists initially considered that Alzheimer's disease is a complex disease with genetic and environmental factors and other complex causes, such as gender, age, family history, and Down syndrome [8][9][10]. However, the actual pathogenesis of Alzheimer's disease is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Amyloidosis in Alzheimer’s Disease: Pathogeny, Etiology, and Related Therapeutic Directions

Hong

Yang

2022

Molecules

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The amyloid hypothesis of Alzheimer’s disease has long been the predominant theory, suggesting that Alzheimer’s disease is caused by the accumulation of amyloid beta protein (Aβ) in the brain, leading to neuronal toxicity in the central nervous system (CNS). Because of breakthroughs in molecular medicine, the amyloid pathway is thought to be central to the pathophysiology of Alzheimer’s disease (AD). Currently, it is believed that altered biochemistry of the Aβ cycle remains a central biological feature of AD and is a promising target for treatment. This review provides an overview of the process of amyloid formation, explaining the transition from amyloid precursor protein to amyloid beta protein. Moreover, we also reveal the relationship between autophagy, cerebral blood flow, ACHE, expression of LRP1, and amyloidosis. In addition, we discuss the detailed pathogenesis of amyloidosis, including oxidative damage, tau protein, NFTs, and neuronal damage. Finally, we list some ways to treat AD in terms of decreasing the accumulation of Aβ in the brain.

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Environmental toxins and Alzheimer's disease progression

Cited by 25 publications

References 175 publications

Synthesis and Biological Evaluation of Halogenated E-Stilbenols as Promising Antiaging Agents

Synthesis and Biological Evaluation of Halogenated E-Stilbenols as Promising Antiaging Agents

Alzheimer’s Disease: Perspective on Therapeutic Options and Recent Hallmarks in Clinical Research

Amyloidosis in Alzheimer’s Disease: Pathogeny, Etiology, and Related Therapeutic Directions

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