Environmental toxin-induced acute kidney injury

Vervaet, Benjamin A.; D’Haese, Patrick C.; Verhulst, Anja

doi:10.1093/ckj/sfx062

Cited by 63 publications

(35 citation statements)

References 153 publications

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“…Since then, AAN has raised worldwide attention (Jadot et al, 2017). Long-term ingestion of herbal formula known or suspected to contain AAs is one of the prominent risk factors for developing AAN (Jia et al, 2005; Vervaet et al, 2017). Although the sale and use of AA-containing products are banned or restricted in most of the countries (Krell and Stebbing, 2013), AAN induced by numerous herbal remedies and products are still reported from all over the world (Lord et al, 1999; Yang et al, 2006; Debelle et al, 2008; Shaohua et al, 2010; Wu et al, 2012; Vaclavik et al, 2014; Ban et al, 2018).…”

Section: Aristolochic Acid-induced Adverse Reactionsmentioning

confidence: 99%

Systematic Overview of Aristolochic Acids: Nephrotoxicity, Carcinogenicity, and Underlying Mechanisms

et al. 2019

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Aristolochic acids (AAs) are a group of toxins commonly present in the plants of genus Aristolochia and Asarum , which are spread all over the world. Since the 1990s, AA-induced nephropathy (AAN) and upper tract urothelial carcinoma (UTUC) have been reported in many countries. The underlying mechanisms of AAN and AA-induced UTUC have been extensively investigated. AA-derived DNA adducts are recognized as specific biomarkers of AA exposure, and a mutational signature predominantly characterized by A→T transversions has been detected in AA-induced UTUC tumor tissues. In addition, various enzymes and organic anion transporters are involved in AA-induced adverse reactions. The progressive lesions and mutational events initiated by AAs are irreversible, and no effective therapeutic regimen for AAN and AA-induced UTUC has been established until now. Because of several warnings on the toxic effects of AAs by the US Food and Drug Administration and the regulatory authorities of some other countries, the sale and use of AA-containing products have been banned or restricted in most countries. However, AA-related adverse events still occur, especially in the Asian and Balkan regions. Therefore, the use of AA-containing herbal remedies and the consumption of food contaminated by AAs still carry high risk. More strict precautions should be taken to protect the public from AA exposure.

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Section: Aristolochic Acid-induced Adverse Reactionsmentioning

confidence: 99%

Systematic Overview of Aristolochic Acids: Nephrotoxicity, Carcinogenicity, and Underlying Mechanisms

et al. 2019

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“…Recently, Sun et al (2012) reported that melamine was gradually degraded into cyanuric acid by rumen microorganisms in lactating dairy cows (Sun et al 2012). It seems that the addition of melamine is to increase nitrogen levels in fertilizer and animal food, consequently, measurement of protein levels is uncertain because many methods mainly estimate amount of nitrogen in the substrates (Dalal & Goldfarb 2011;Hau et al 2009;Vervaet et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Effects of Melamine and Cyanuric Acid on Renal Function and Structure in Rats

Peerakietkhajorn¹,

Huipao²,

Hiranyachattada³

2019

JSM

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Melamine has been used to increase the amount of measurable nitrogen which is a component of protein. The renal toxicity of melamine has been reported in infants and animals that consumed a mixture of melamine in their food products. This study aimed to investigate the effects of melamine on rat renal function using clearance and histological techniques. Animals were divided into 3 groups: vehicle control, 400 mg/kg melamine and mixture of 400 mg/kg melamine and 400 mg/kg cyanuric acid (p.o., daily for three days). The results showed that blood urea nitrogen level significantly increased in the rats treated with the mixture of melamine and cyanuric acid. The urine flow rate, glomerular filtration rate, renal plasma flow and urinary sodium and potassium excretion rate significantly decreased when compared to vehicle control. These results suggested both glomeruli and renal tubules of rats treated with mixture of melamine and cyanuric acid were damaged. Histological study also confirmed these findings and showed significant glomerular atrophy and dilated renal tubules. Numerous clear brownish-yellow crystals were also found in the distal tubule, collecting tubule and papillary duct. However, rats solely treated with melamine showed no significant difference in renal function or structures.

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“…High levels of metals (e.g. As or Cd) can induce acute kidney injury and have been proposed as biomarkers of kidney injury of other types, however it is unclear if, or at what levels, these metals cause chronic kidney injury (29).…”

Section: Key Resultsmentioning

confidence: 99%

Environmental exposures in young adults with declining kidney function in a population at risk of Mesoamerican nephropathy

et al. 2019

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ObjectivesThere is an epidemic of Mesoamerican nephropathy (MeN) in Central America, where sugarcane production is prominent. Numerous causes are proposed, but to date limited evidence supports any one hypothesis. A nested case–control study using biosamples from a rural, community-based follow-up study of 350 young adults from Northwest Nicaragua at risk of MeN was conducted with the aim of characterising the associations between urinary concentrations of metals, pesticides and mycotoxins from samples collected in the first 6 months and decline in kidney function over 2 years.MethodsUrine samples collected at baseline (pre-sugarcane harvest) and the first 6 month follow-up (post-sugarcane harvest) visit were tested. Twelve metals and metalloids (aluminium, total arsenic, cadmium, chromium, cobalt, copper, lead, manganese, mercury, selenium, silicon and strontium) were analysed by inductively coupled plasma-mass spectrometry. Twelve pesticides or their metabolites (2,4-dichlorophenoxyacetic acid, 3-phenoxybenzoic acid, 4-fluoro-3-phenoxybenzoic acid, chloro-3,3,3-trifluoro-1-propen-1-yl-2,2-dimethylcyclopropanecarboxylic acid, cis/trans 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid, ethylenethiourea, glyphosate, 4-chloro-2-methylphenoxy acetic acid, 3-hydroxy-pyrimetanil, 5-hydroxytiabendazole, hydroxy-tebuconazole and 3,5,6-trichloro-2-pyridinol) and two mycotoxins (ochratoxin A (OTA) and citrinin (CIT)) were analysed by liquid chromatography coupled-mass spectrometry. Differences in the creatinine-corrected urinary concentrations of the measured exposures between outcome groups (participants with stable vs declining kidney function) were examined.ResultsElevated levels of aluminium and total arsenic as well as metabolites of several pesticides were detected across the population. No differences were identified between the declining and stable groups in the levels of metals or pesticides tested. OTA and CIT were below the limit of detection.ConclusionsThe tested metals, metalloids, pesticides and mycotoxins were not associated with loss of kidney function in participants at-risk of MeN.

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Environmental toxin-induced acute kidney injury

Cited by 63 publications

References 153 publications

Systematic Overview of Aristolochic Acids: Nephrotoxicity, Carcinogenicity, and Underlying Mechanisms

Systematic Overview of Aristolochic Acids: Nephrotoxicity, Carcinogenicity, and Underlying Mechanisms

Effects of Melamine and Cyanuric Acid on Renal Function and Structure in Rats

Environmental exposures in young adults with declining kidney function in a population at risk of Mesoamerican nephropathy

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