Environmental safety and mode of action of a novel curcumin-based photolarvicide

Souza, Luciano Melo de; Garbuio, Matheus; Inada, Natália Mayumi; Souza, José Paulo de; Kurachi, Cristina; Oliveira, Kléber T. de; Bagnato, Vanderlei Salvador

doi:10.1007/s11356-020-09210-4

Cited by 11 publications

(14 citation statements)

References 78 publications

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“…The use of curcumin, a natural PS extracted from the rhizomes of Curcuma longa plant, represents an ecologically positive alternative for vector control, since this molecule is already present in nature and can be easily degraded, being less harmful to the environment and non‐target organisms 17–19 . Some studies also showed that extracts and essential oils from Curcuma longa have larvicidal and repellent activity, 20,21 as well as isolated curcuminoids 22 .…”

Section: Introductionmentioning

confidence: 99%

“…Aiming to address it, de Souza and co‐authors developed a water‐soluble curcumin/d‐mannitol (DMC) formulation, 9 and the best photolarvicidal efficacy (LC 50 = 0.02 mg L −1 ) was observed so far. In addition, according to Venturini and co‐authors, DMC has also proven to be non‐toxic to non‐target aquatic organisms (concentrations up to 100 mg L −1 ), has it was investigated using Danio rerio and Daphnia magna as two models to standard toxicity tests 18 …”

Section: Introductionmentioning

confidence: 99%

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Curcumin/d‐mannitol as photolarvicide: induced delay in larval development time, changes in sex ratio and reduced longevity of Aedes aegypti

Mezzacappo

Souza

Inada

et al. 2021

Pest Management Science

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BACKGROUND Resistant populations of Ae. aegypti have been a major problem in arboviruses epidemic areas, generating a strong demand for novel methods of vector control. In this regard, our group has demonstrated the use of curcumin as an efficient photoactive larvicide to eliminate Ae. aegypti larvae. This work was aimed to evaluate the Ae. aegypti (Rockefeller) development under sublethal conditions, using a curcumin/d‐mannitol (DMC) formulation. The photolarvicidal efficacy under semi‐field and field conditions (wild populations) was also analyzed, as well as the photobleaching and residual activity of DMC. RESULTS A delay in development time when larvae were exposed to sublethal concentrations of DMC was observed, followed by significant changes in sex ratio and reduction in longevity. DMC also presented a low residual activity when compared to usual larvicides, and had a substantial photolarvicidal activity against wild populations in field trials, achieving 71.3% mortality after 48 h. CONCLUSIONS Overall, these findings are of great biological importance for the process of enabling the implementation of DMC as a new product in the control of Ae. aegypti larvae, and contributes to the improvement of new plant‐based larvicides. © 2021 Society of Chemical Industry

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Curcumin/d‐mannitol as photolarvicide: induced delay in larval development time, changes in sex ratio and reduced longevity of Aedes aegypti

Mezzacappo

Souza

Inada

et al. 2021

Pest Management Science

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“…For D-mannitol formulations, a larval mortality was verified with

values between 0.01 and 0.02 mg L −1 and a significant decrease in the hatching rate of eggs (10% at 100 mg L −1 ) [ 16 ]. Additionally, it has been reported that these formulations of curcumin with sugars (sucrose or D-mannitol) are non-toxic to the organisms Daphnia magna and Danio rerio [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

“…Although studies have proved the photolarvicidal potential of curcumin to deal with Ae. aegypti larvae [ 16 , 26 ], points still need to be addressed before its application in the environment, including field tests and studies on the possible environmental impact related to its photodegradation. Curcumin is a well-established non-toxic molecule; however, there is a lack of information on the toxicity of photoproducts of curcumin.…”

Section: Introductionmentioning

confidence: 99%

Environmentally Safe Photodynamic Control of Aedes aegypti Using Sunlight-Activated Synthetic Curcumin: Photodegradation, Aquatic Ecotoxicity, and Field Trial

Lima

Silva

et al. 2022

Molecules

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This study reports curcumin as an efficient photolarvicide against Aedes aegypti larvae under natural light illumination. Larval mortality and pupal formation were monitored daily for 21 days under simulated field conditions. In a sucrose-containing formulation, a lethal time 50 (LT50) of 3 days was found using curcumin at 4.6 mg L−1. This formulation promoted no larval toxicity in the absence of illumination, and sucrose alone did not induce larval phototoxicity. The photodegradation byproducts (intermediates) of curcumin were determined and the photodegradation mechanisms proposed. Intermediates with m/z 194, 278, and 370 were found and characterized using LC-MS. The ecotoxicity of the byproducts on non-target organisms (Daphnia, fish, and green algae) indicates that the intermediates do not exhibit any destructive potential for aquatic organisms. The results of photodegradation and ecotoxicity suggest that curcumin is environmentally safe for non-target organisms and, therefore, can be considered for population control of Ae. aegypti.

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“…Los rizomas de cúrcuma (Curcuma Longa L.) son utilizados en la gastronomía, la farmacéutica y la nanotecnología, por mencionar algunos. Estos rizomas contienen entre 2% y 5% de curcumina, un compuesto polifenólico de color amarillo (Aggarwal et al, 2007), reconocido como seguro para su consumo y amigable con el medio ambiente (Grynkiewicz & Ślifirski, 2012;Venturini et al, 2020).…”

Section: Introductionunclassified

Extracto hidroalcohólico de cúrcuma (Curcuma longa L.) como indicador en titulación ácido base de alimentos

García-Elizalde

2021

Acta Universitaria

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La curcumina es un pigmento amarillo brillante presente en los rizomas de cúrcuma. Este pigmento es un ácido débil Brönsted-Lowry que vira de amarillo a rojo al cambiar el pH de ácido a básico. Se elaboró y evaluó un extracto hidroalcohólico de cúrcuma (EHC) como indicador de titulación de un ácido débil con una base fuerte frente a fenolftaleína. Los rizomas de cúrcuma se desinfectaron deshidrataron y maceraron en etanol-agua. Se titularon series de alícuotas de yogurt natural, refresco sabor limonada y jugo fresco de piña. Empleando EHC, los porcentajes de acidez mostraron repetibilidad. El estimado de acidez del yogurt utilizando EHC mostró elevada desviación estándar. La prueba de probabilidad exacta de Fisher (asumiendo p = 0.05) arrojó igualdad de medianas de acidez en refresco y jugo de piña, pero no para yogurt. En consecuencia, el EHC elaborado aporta estimaciones precisas de acidez y similares a las obtenidas con fenolftaleína para refresco sabor limonada y jugo fresco de piña.

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Environmental safety and mode of action of a novel curcumin-based photolarvicide

Cited by 11 publications

References 78 publications

Curcumin/d‐mannitol as photolarvicide: induced delay in larval development time, changes in sex ratio and reduced longevity of Aedes aegypti

Curcumin/d‐mannitol as photolarvicide: induced delay in larval development time, changes in sex ratio and reduced longevity of Aedes aegypti

Environmentally Safe Photodynamic Control of Aedes aegypti Using Sunlight-Activated Synthetic Curcumin: Photodegradation, Aquatic Ecotoxicity, and Field Trial

Extracto hidroalcohólico de cúrcuma (Curcuma longa L.) como indicador en titulación ácido base de alimentos

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