Environmental Risks for Spondyloarthropathies

Farran, Yvette; Reveille, John D.; Hwang, Meeyul

doi:10.1016/j.rdc.2022.06.004

Cited by 6 publications

(1 citation statement)

References 88 publications

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“…Palindromic SNPs and SNPs not present in the outcomes (AS, PsA, and EA) were excluded from the instrumental variables. We utilized the PhenoScanner database ( http://www.phenoscanner.medschl.cam.ac.uk/phenoscanner , accessed on 7 October 2022) to exclude confounding factors reported in the literature, including body mass index (BMI) and smoking ( 26 ). Linkage disequilibrium was eliminated using a threshold of r 2 < 0.001 and a clumping distance of 10,000 kb.…”

Section: Methodsmentioning

confidence: 99%

Causal association of gut microbiota on spondyloarthritis and its subtypes: a Mendelian randomization analysis

Tang,

Mo,

Fan

et al. 2024

Front. Immunol.

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BackgroundDespite establishing an association between gut microbiota and spondyloarthritis (SpA) subtypes, the causal relationship between them remains unclear.MethodsGut microbiota data were obtained from the MiBioGen collaboration, and SpA genome-wide association study (GWAS) summary data were obtained from the FinnGen collaboration. We conducted a two-sample Mendelian randomization (MR) analysis using the inverse-variance-weighted method supplemented with four additional MR methods (MR-Egger, weighted median, simple mode, and weighted mode). Pleiotropy and heterogeneity were also assessed. Reverse MR analysis was used to detect reverse causal relationships.ResultsWe identified 23 causal links between specific gut microbiota taxa and SpA levels. Of these, 22 displayed nominal causal associations, and only one demonstrated a robust causal connection. Actinobacteria id.419 increased the risk of ankylosing spondylitis (AS) (odds ratio (OR) = 1.86 (95% confidence interval (CI): 1.29–2.69); p = 8.63E−04). The family Rikenellaceae id.967 was associated with a reduced risk of both AS (OR = 0.66 (95% CI: 0.47–0.93); p = 1.81E−02) and psoriatic arthritis (OR = 0.70 (95% CI: 0.50–0.97); p = 3.00E−02). Bacillales id.1674 increased the risk of AS (OR = 1.23 (95% CI: 1.00–1.51); p = 4.94E−02) and decreased the risk of enteropathic arthritis (OR = 0.56 (95% CI: 0.35–0.88); p = 1.14E−02). Directional pleiotropy, or heterogeneity, was not observed. No reverse causal associations were observed between the diseases and the gut microbiota.ConclusionOur MR analysis suggested a genetic-level causal relationship between specific gut microbiota and SpA, providing insights into the underlying mechanisms behind SpA development mediated by gut microbiota.

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Section: Methodsmentioning

confidence: 99%

Causal association of gut microbiota on spondyloarthritis and its subtypes: a Mendelian randomization analysis

Tang,

Mo,

Fan

et al. 2024

Front. Immunol.

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Immunologische Störung durch intestinale Dysbiose und Stress als wesentliche Grundlage der reaktiven Arthritis

He,

Qian

2024

Z Rheumatol

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Reactive arthritis (ReA) is defined as arthritis resulting from infections in other body parts, such as the gastrointestinal and urogenital tracts. The primary clinical manifestations involve acute-onset and self-limiting asymmetric large joint inflammation in the lower limbs. Although bacterial or chlamydia infections have long been recognized as playing a pivotal role in its pathogenesis, recent studies suggest that antibiotic treatment may perpetuate rather than eradicate chlamydia within the host, indicating an involvement of other mechanisms in Reactive arthritis. Reactive arthritis is currently believed to be associated with infection, genetic marker (HLA-B27), and immunologic derangement. As an autoimmune disease, increasing attention has been given to understanding the role of the immune system in Reactive arthritis. This review focuses on elucidating how the immune system mediates reactive arthritis and explores the roles of intestinal dysbiosis-induced immune disorders and stress-related factors in autoimmune diseases, providing novel insights into understanding reactive arthritis.

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6-formylindolo[3, 2-b]carbazole alters gut microbiota and prevents the progression of ankylosing spondylitis in mice

Liu,

Wang,

Yang

et al. 2024

International Immunopharmacology

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Environmental Risks for Spondyloarthropathies

Cited by 6 publications

References 88 publications

Causal association of gut microbiota on spondyloarthritis and its subtypes: a Mendelian randomization analysis

Causal association of gut microbiota on spondyloarthritis and its subtypes: a Mendelian randomization analysis

Immunologische Störung durch intestinale Dysbiose und Stress als wesentliche Grundlage der reaktiven Arthritis

6-formylindolo[3, 2-b]carbazole alters gut microbiota and prevents the progression of ankylosing spondylitis in mice

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