Environmental risk of titanium dioxide nanoparticle and cadmium mixture: developmental toxicity assessment in zebrafish (Danio rerio)

Mamboungou, Joseph; Canedo, Aryelle; Qualhato, Gabriel; Rocha, Thiago Lopes; Vieira, Lucélia Gonçalves

doi:10.1007/s11051-022-05561-w

Cited by 5 publications

(1 citation statement)

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“…Titanium dioxide nanoparticles (TiO 2 NPs) are engineered nanoparticles that are very common worldwide since they have applications in many fields, such as paints, packaging, sunscreen, pharmaceuticals, water depuration, photoelectrochemical solar cells, and photovoltaic systems [ 15 , 16 , 17 ]. It is well known that titanium dioxide (TiO 2 ) is a good photocatalyst that, under UV illumination, generates energy-rich electron–hole pairs that can be transferred to the surface of the TiO 2 .…”

Section: Introductionmentioning

confidence: 99%

Toxicity of Titanium Dioxide–Cerium Oxide Nanocomposites to Zebrafish Embryos: A Preliminary Evaluation

Pecoraro,

Scalisi,

Indelicato

et al. 2023

Toxics

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The widespread use of metal nanoparticles in different fields has raised many doubts regarding their possible toxicity to living organisms and the accumulation and discharge of metals in fish species. Among these nanoparticles, titanium dioxide (TiO2) and cerium oxide (CeO2) nanoparticles have mainly been employed in photocatalysis and water depuration. The aim of this research was to evaluate the potential toxic effects, after a co-exposure of TiO2-3%CeO2 nanoparticles, on zebrafish development, using an acute toxicity test. Increasing concentrations of TiO2-3%CeO2 nanoparticles were used (0.1-1-10-20 mg/L). The heartbeat rate was assessed using DanioscopeTM software (version 1.2) (Noldus, Leesburg, VA, USA), and the responses to two biomarkers of exposure (Heat shock proteins-70 and Metallothioneins) were evaluated through immunofluorescence. Our results showed that the co-exposure to TiO2-3%CeO2 nanoparticles did not affect the embryos’ development compared to the control group; a significant difference (p < 0.05) at 48 hpf heartbeat for the 1, 10, and 20 mg/L groups was found compared to the unexposed group. A statistically significant response (p < 0.05) to Heat shock proteins-70 (Hsp70) was shown for the 0.1 and 1 mg/L groups, while no positivity was observed in all the exposed groups for Metallothioneins (MTs). These results suggest that TiO2-3%CeO2 nanocomposites do not induce developmental toxicity; instead, when considered separately, TiO2 and CeO2 NPs are harmful to zebrafish embryos, as previously shown.

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Section: Introductionmentioning

confidence: 99%