Environmental Risk Assessment of Time‐Variable Toxicant Exposure with Toxicokinetic–Toxicodynamic Modeling of Sublethal Endpoints and Moving Time Windows: A Case Study with Ceriodaphnia dubia
Carlo Romoli,
Marie Trijau,
Erik B. Muller
et al.
Abstract:Toxicokinetic–toxicodynamic (TKTD) modeling has received increasing attention in terms of the regulatory environmental risk assessment of chemicals. This type of mechanistic model can integrate all available data from individual‐level bioassays into a single framework and enable refined risk assessments by extrapolating from laboratory results to time‐variable exposure scenarios, based, for instance, on surface water exposure modeling (e.g., FOCUS). Dynamic energy budget (DEB) models coupled with TKTD modules … Show more
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