Environmental risk assessment of ionophores

Hansen, Martin; Krogh, Kristine A.; Björklund, Erland; Halling-Sørensen, Bent; Brandt, Åse

doi:10.1016/j.trac.2009.02.015

Cited by 54 publications

(42 citation statements)

References 25 publications

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“…Corresponding K d values of 17.64 and 8.52 were observed for monensin, the lowest for both soils. Average K d values observed in this study were higher than earlier studies done elsewhere on various type of field soils (Sassman and Lee 2007;Lertpaitoonpan et al 2009;Hansen et al 2009b). These higher values could be due to higher organic matter percentage and composition, inorganic soil sorption, or simultaneously occurring biotic and/ or abiotic degradation processes.…”

Section: Sorptioncontrasting

confidence: 82%

“…Based on the usage and detected environmental concentrations, ionophores are considered as high risk compounds (Hansen et al 2009b). However, preference for particular ionophores is regional and country based.…”

Section: Introductionmentioning

confidence: 99%

“…A number of recent studies have detected these compounds in environmental matrices (Lissemore et al 2006;Watanabe et al 2008;Onesios et al 2009). In North America, priority in usage is allotted to monensin, in Denmark and Korea to salinomycin, in Sweden and Norway to narasin (Hansen et al 2009b). These three ionophores have been chosen for this study.…”

Section: Introductionmentioning

confidence: 99%

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Understanding the Sorption of Ionophoric Pharmaceuticals in a Treatment Wetland

Hussain

Prasher

2011

Wetlands

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Constructed treatment wetlands provide a costeffective and efficient technique for removal of veterinary anticoccidials from agricultural wastewaters. A sorption study was conducted for three ionophoric antibiotics, monensin, salinomycin, and narasin, on sandy clay loam and sandy soils collected from two constructed wetlands. The effect of pH on sorption was also monitored. At the field pH of 6.8, sandy clay loam soil was found to have higher K d (98.8-17.65 Lkg −1 ) and Log K oc (5.03-4.28 Lkg −1 ) values for all three antibiotics compared to the sandy soil (K d 38.24-8.52 Lkg −1 and Log K oc 4.91-4.26 Lkg −1 ). Narasin showed the highest K d and K oc , whereas the lowest were observed for monensin. The sorption of compounds manifested an inverse relation with pH, however the decrease in K oc with increasing pH was considerably dampened due to specific solution characteristics of ionophores. Sorption factor will have the least and greatest effect in reducing mobility of the monensin and narasin compounds, respectively. The soil sterilization method of autoclaving was not found to be suitable for the soil and compounds evaluated.

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Section: Sorptioncontrasting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Understanding the Sorption of Ionophoric Pharmaceuticals in a Treatment Wetland

Hussain

Prasher

2011

Wetlands

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“…1,16−21 Residual IPAs might pose a risk based on an environmental risk assessment following European Union guidelines, which stated that comprehensive data on the environmental fate and biological effects of IPAs are lacking. 1,22 Veterinary antibiotics, applied to agricultural fields with animal waste used as fertilizers, have been reorganized to significantly impact the local structure and function of soil bacteria, as well as to potentially lead to the development and proliferation of antibiotic resistance genes even at subinhibitory concentrations. 23 Several previous studies investigated the development of IPA-resistant bacteria isolated from animals.…”

Section: ■ Introductionmentioning

confidence: 99%

Inhibition and Biotransformation Potential of Veterinary Ionophore Antibiotics under Different Redox Conditions

Sun

Huang

Pavlostathis

2014

Environ. Sci. Technol.

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Veterinary ionophore antibiotics (IPAs) are polyether compounds used extensively in the livestock industry to promote animal growth and prevent coccidia infection. However, the environmental fate and impact of IPAs are not fully understood. In this study, the inhibition and biotransformation potential of the most commonly used IPAs, monensin (MON) and salinomycin (SAL), were investigated under well-defined aerobic, nitrate-reducing, fermentative/sulfate-reducing, and fermentative/methanogenic conditions. Batch assays were conducted with mixed cultures developed from poultry litter (PL), PL-fertilized soil, and municipal anaerobic sludge. Significant transformation of MON and SAL was observed in aerobic, low-buffer capacity culture series as a result of abiotic acid-catalyzed IPAs hydrolysis induced by nitrification. Biotransformation of IPAs was the main transformation process in aerobic, high-buffer capacity culture series. MON persisted under fermentative/sulfate-reducing conditions, whereas SAL was transformed by fermentative bacteria. Both MON and SAL were stable under nitrate-reducing and methanogenic conditions. At IPAs concentrations up to 1 mg/L, MON inhibited only methanogenesis, whereas SAL did not impact any of the biological processes investigated in this study. Multiple, new primary IPA biotransformation products were observed on LC/MS, and their molecular structures were tentatively identified by analyzing LC/MS/MS fragmentation patterns. Overall, MON and SAL exhibited different inhibition and biotransformation patterns at each redox condition tested, which could greatly influence their fate and impact upon their release into the environment as a result of agricultural activities.

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“…Studies reported by Hansen et al (2009) showed that both Salinomycin and Narasin may pose a risk to terrestrial organisms as predicted environmental concentrations determined under regulatory standards were sufficiently high for fatalities to occur. Hansen et al (2009) also demonstrated an environmental risk to aquatic organisms particularly those dwelling in the sediment compartment. Concerns for aquatic systems are supported by the aquatic toxicity to Oncorhynchus mykiss of monensin sodium (96hr LC 50 9.0 mg l -1 ) and to Daphnia magna (LC 50 7.29 mg l -1 ).…”

Section: Toxicity Ecotoxicity and Adverse Effects For Target Speciesmentioning

confidence: 99%

Review of substances/agents that have direct beneficial effect on the environment: mode of action and assessment of efficacy

Lewis

Tzilivakis

Green

et al. 2013

EFSA Supporting Publications

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Some substances and agents, used as livestock feed additives, could have an important role to play in delivering sustainable increases in productivity and simultaneous reductions in damaging pollutants. This research project aimed to identify livestock feed additives which may have potential benefits for the environment and create an inventory of these which included other relevant scientific and descriptive data. This is the final report of the project. It provides a detailed description of the methodology used and the research findings.The project considered over 620 scientific publications, reports and other documents which led to data for around 300 studies and 246 substances and agents with potential to be used as feed additives to be reviewed. Of the 246 substances and agents explored, 130 were found to offer potential benefits to the environment and, for some substances, the benefits could be very significant. In addition to data on efficacy the study also considered scientific methodologies, analytical approaches and statistical techniques used within the studies. The project also collated data relating to the physicochemical properties, and human and wildlife toxicity for each of the 130 substances and agents.© University of Hertfordshire, 2013 KEY WORDSEnvironment, feed additives, livestock, emissions DISCLAIMERThe present document has been produced and adopted by the bodies identified above as author(s). This task has been carried out exclusively by the author(s) in the context of a contract between the European Food Safety Authority and the author(s), awarded following a tender procedure. The present document is published complying with the transparency principle to which the Authority is subject. It may not be considered as an output adopted by the Authority. The European food Safety Authority reserves its rights, view and position as regards the issues addressed and the conclusions reached in the present document, without prejudice to the rights of the authors. The present document has been produced and adopted by the bodies identified above as author(s). This task has been carried out exclusively by the author(s) in the context of a contract between the European Food Safety Authority and the author(s), awarded following a tender procedure. The present document is published complying with the transparency principle to which the Authority is subject. It may not be considered as an output adopted by the Authority. The European Food Safety Authority reserves its rights, view and position as regards the issues addressed and the conclusions reached in the present document, without prejudice to the rights of the authors. SUMMARYSome substances and agents, used as livestock feed additives, could have an important role to play in delivering sustainable increases in productivity and simultaneous reductions in damaging pollutants. This research project aimed to identify livestock feed additives which may have potential benefits for the environment and create an inventory of these which includes other...

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Environmental risk assessment of ionophores

Cited by 54 publications

References 25 publications

Understanding the Sorption of Ionophoric Pharmaceuticals in a Treatment Wetland

Understanding the Sorption of Ionophoric Pharmaceuticals in a Treatment Wetland

Inhibition and Biotransformation Potential of Veterinary Ionophore Antibiotics under Different Redox Conditions

Review of substances/agents that have direct beneficial effect on the environment: mode of action and assessment of efficacy

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