Environmental Risk Assessment of antimicrobials applied in veterinary medicine—A field study and laboratory approach

Slana, Marko; Dolenc, Marija Sollner

doi:10.1016/j.etap.2012.11.017

Cited by 35 publications

(32 citation statements)

References 41 publications

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“…As previously discussed, the most part of OTC is excreted via urine and faeces in its original form (EMA ; Rigos & Troisi ; Sekkin & Kum ; Romero et al . ; Slana & Dolenc ). According to several authors (Schmidt et al .…”

Section: Environmental Fatementioning

confidence: 96%

“…After reaching the natural aquatic system, the environmental fate of a compound is strongly dependent on its molecular structure and its physical–chemical properties, such as the Henry's constant, the octanol‐water partitioning constant K ow , the water solubility and the adsorption to the particulate matter (mineral or organic) (Slana & Dolenc ). Henry's law constant of OTC is low (3.91 × 10 −26 atm m 3 mol −1 ), which means that OTC molecules are weakly lost by volatilization (Daghrir & Drogui ).…”

Section: Environmental Fatementioning

confidence: 99%

See 1 more Smart Citation

Oxytetracycline in intensive aquaculture: water quality during and after its administration, environmental fate, toxicity and bacterial resistance

Leal

Santos

Esteves

2018

Reviews in Aquaculture

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Oxytetracycline (OTC) is one of the most used antibiotics in aquaculture. This raises concerns due to its effects in human and animal health, the environmental contamination and the consequences arising therefrom. This review focuses on the OTC application in intensive aquaculture. It compiles and complements the dispersed information, presenting a comprehensive study about the OTC effects, from its administration to farmed fish, until its release into the surrounding aquatic systems. Several topics about OTC are presented and discussed: physicalchemical properties, interaction with ions, application to farmed fish, effects in water quality and possible treatments, biological activity and toxicity of OTC byproducts, environmental fate. Based on the information gathered, one concludes that OTC establishes strong complexes with Ca 2+ and Mg 2+ , which may have implications on its biological activity. OTC acts as inhibitor of protein synthesis and is poorly metabolized or unmetabolized by fish. Its common recommended daily dose is about 75 mg kg À1 but depends on the administration conditions and on target fish species. Regarding OTC removal from water within a semiclosed aquaculture's water circuit, ozonation and photodegradation are not completely efficient methods as none of them promotes total mineralization. However, photodegradation can be applied as a complementary method prior to ozonation, allowing to reduce costs. OTC by-products do not appear to retain its biological activity, but toxicity studies mimicking environmental conditions were not found. In open circuits (cages), water column where OTC is administered not suffer a specific treatment and the antibiotic is easily spread by the surrounding environments, affecting their inhabitants. OTC is released in the aquatic system in freely dissolved form and/or associated with organic or inorganic compounds, being subjected to natural photolysis, hydrolysis and/or biodegradation.

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Section: Environmental Fatementioning

confidence: 96%

Section: Environmental Fatementioning

confidence: 99%

Oxytetracycline in intensive aquaculture: water quality during and after its administration, environmental fate, toxicity and bacterial resistance

Leal

Santos

Esteves

2018

Reviews in Aquaculture

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“…Despite the fact that these compounds have a low acute toxicity, they may affect aquatic life chronically because of variability in their half-lives in water, ranging from hours to years (Slana and Dolenc, 2013). In mammals, antibiotic clearance involves the CYP3A4 (erythromycin and clarithromycin, ciprofloxacin), CYP1A2 (ciprofloxacin) or CYP2D6 (ciprofloxacin) enzymes (Hersh and Moore, 2004;Westphal, 2000).…”

Section: Antibioticsmentioning

confidence: 98%

Effects of pharmaceuticals present in aquatic environment on Phase I metabolism in fish

Burkina

Žlábek

Zamaratskaia

2015

Environmental Toxicology and Pharmacology

120

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“…There are several concerns about veterinary drug residues that exceed the maximum residue limits (MRLs) in products consumed by humans because they may cause several disorders such as carcinogenesis, teratogenic, mutagenic, and allergy (1)(2)(3). Bioaccumulation of antimicrobials in edible food sources can occur in fish, crustaceans, water, sediment, and plants (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

The Analysis of Oxytetracycline Residue in Tissues of Cultured Rainbow Trout (Oncorhynchus Mykiss)

et al. 2017

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Background: Oxytetracycline (OTC) is commonly used in aquaculture industry and has high potency against bacterial diseases. Objectives: The present study aimed at examining the rate of oxytetracycline (OTC) antibiotic residue in the tissues of cultured rainbow trout (Oncorhynchus mykiss). Methods: Samples were taken randomly from the livers and fillets of 45 rainbow trout from 15 large aquaculture ponds in Hamadan province, West of Iran. The OTC residue was measured using high performance liquid chromatography (HPLC). Data analysis was performed with SPSS (V.18) (mean and standard deviation), and Man-Whitney test was employed for statistical analysis. Results:The results revealed that OTC residue were 389 to 641 ppb in the livers and 175 to 295 ppb in the fillets, respectively. However, in 86.66% of the samples (liver and fillet) the amounts of OTC residue was found to be higher than the maximum residue limits (MRLs) in codex alimentarius commission, and 13.33% of the samples (liver and fillet) were within the standard range. Analysis of input and output data using Man-Whitney test showed significant differences in liver and fillet (P < 0.05). Conclusions:This research determined that the use of OTC must be reduced to an acceptable level in aquaculture industry. Also, antibiotic residue in rainbow trout must be controlled before their delivery to the market.

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Environmental Risk Assessment of antimicrobials applied in veterinary medicine—A field study and laboratory approach

Cited by 35 publications

References 41 publications

Oxytetracycline in intensive aquaculture: water quality during and after its administration, environmental fate, toxicity and bacterial resistance

Oxytetracycline in intensive aquaculture: water quality during and after its administration, environmental fate, toxicity and bacterial resistance

Effects of pharmaceuticals present in aquatic environment on Phase I metabolism in fish

The Analysis of Oxytetracycline Residue in Tissues of Cultured Rainbow Trout (Oncorhynchus Mykiss)

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