Environmental risk assessment of antibiotics in the Swedish environment with emphasis on sewage treatment plants

Lindberg, Richard H.; Björklund, Karin; Rendahl, Per; Johansson, Magnus; Tysklind, Mats; Andersson, Barbro

doi:10.1016/j.watres.2006.11.014

Cited by 129 publications

(79 citation statements)

References 22 publications

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“…A similar method has also been presented for determination of antibiotics in sewage waters [7]. Reversed phase HPLC coupled with mass spectrometry has frequently been used for determination of many antibiotic substances [7][8].…”

Section: Hplc-ms/ms Analysismentioning

confidence: 99%

“…There are no methods available for such screening studies. Reversed phase liquid chromatography coupled with mass spectrometry (HPLC-MS) has, however, frequently been used for determination of many antibiotic substances in sewers and waste waters [7][8]. Similar methods have also been developed for screening spill and leakage of antineoplastic drugs.…”

Section: Introductionmentioning

confidence: 99%

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Development of a Method for Screening Spill and Leakage of Antibiotics on Surfaces Based on Wipe Sampling and HPLC-MS/MS Analysis

Nygren

2011

Surface and Dermal Sampling

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A screening method for determination of spill and leakage of twelve different antibiotic substances has been developed. The method is based on wipe sampling where the sampling procedure has been simplified for screening purposes. After sample processing, the antibiotic substances are determined by liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS). Twelve antibiotic substances can be determined in the screening method:Cefadroxil, Cefalexin, Ciprofloxacin, Demeclocyklin HCl, Diaveridin, Doxycyklin, Enrofloxacin, Flukonazol, Metronidazol, Norfloxacin, Ofloxacin and Trimetoprim. These substances are active components in antibiotic drugs frequently used in Sweden. For screening investigations using collection of wipe samples, good or acceptable performance was obtained for ten substances on three or more surface materials. Although not fully acceptable, useful performance for screening purposes was also obtained on the other surface materials and for the other substances, except Demeclocyklin HCl, on all surface materials.By employing a classification procedure, where the samples are divided into groups according to increasing contamination of the sample surfaces, screening samples and the contamination level can simply be compared. This classification procedure will also help to circumvent any deficiency in recovery performance for some substances and surface materials.

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Section: Hplc-ms/ms Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of a Method for Screening Spill and Leakage of Antibiotics on Surfaces Based on Wipe Sampling and HPLC-MS/MS Analysis

Nygren

2011

Surface and Dermal Sampling

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“…However, prior reports show the extensive usage of this antibiotic for pharmaceutical purposes has resulted in a widespread contamination of environmental water [4][5][6][7][8][9]. In view that the chemicals could cause adverse effect on the aquatic vertebrates and organisms, and their increased level of bacterial resistance, more and more concerns arose on the potential risk on human health and aquatic ecosystem [10][11][12][13][14]. So, some effective approaches were put forward to monitor FQs in environmental water.…”

Section: Introductionmentioning

confidence: 99%

Upconversion fluorescence resonance energy transfer—a novel approach for sensitive detection of fluoroquinolones in water samples

Zhang

et al. 2016

Microchemical Journal

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A novel homogeneous assay method was put forth for simultaneous sensing of fluoroquinolone derivatives (FQs) in water utilizing the upconversion fluorescence resonance energy transfer (FRET) process based on the competitive reaction between dissolved FQs and labeled AuNPs for FQs Mab connected UCPs. The prepared size-tunable β-NaLuF4:Yb,Er,Gd upconversion phosphors (UCPs) were functionalized with carboxylic acid (COOH-) and monoclonal antibody (Mab, C2F3C2) to act as a donor. The gold nanoparticles (AuNPs) labeled with the corresponding antigen (ciprofloxacin-BSA) take the role of an acceptor. Under optimized conditions, the limit of detections (LODs) for three common FQs, enrofloxacin (ENR), ciprofloxaxin (CIP), and norfloxacin (NOR), were 0.19-0.32 ng/mL based on 3σ. The recoveries were found to be in the range of 73.5-114.5% (normalized value according to the cross-reactivity of Mab) for water samples (tap water, pond water and river water). The proposed approach possesses significant advantages as follows: (i) simple procedure (only one step) without washing and separation steps, and no sample pretreatment other than filtration; (ii) fast liquid-phase kinetics with shortened incubation time; and (iii) high tolerance to various interfering substances. All of which indicated its potentiality as an efficient biosensor towards the monitoring of FQs in aquatic environments.

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“…Thus, due to the high use and continuous release, they can be classified as pseudo-persistent (Barceló and Petrovic, 2007). Karnjanapiboonwong et al, 2011;Kolpin et al, 2002) and may pose a risk to humans and environment because of their continuous release (Lindberg et al, 2007). …”

Section: Personal Care Productsmentioning

confidence: 99%

“…Finally, inappropriate disposal of these compounds is another source that cannot be neglected (Yu and Wu, 2012). Nonetheless, the input sources are well-known, but the fate and behavior of these emerging contaminants in the environment (Guzman et al, 2006;Kohler and Triebskorn, 2013;Lindberg et al, 2007) and their possible introduction into the food chain (plant uptake) (Goldstein et al, 2014;Wu et al, 2013) need further study.…”

Section: Main Pathways Of Emerging Contaminants Into the Environmentmentioning

confidence: 99%

Determination of emerging contaminants in environmental matrices

Aznar¹

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Environmental risk assessment of antibiotics in the Swedish environment with emphasis on sewage treatment plants

Cited by 129 publications

References 22 publications

Development of a Method for Screening Spill and Leakage of Antibiotics on Surfaces Based on Wipe Sampling and HPLC-MS/MS Analysis

Development of a Method for Screening Spill and Leakage of Antibiotics on Surfaces Based on Wipe Sampling and HPLC-MS/MS Analysis

Upconversion fluorescence resonance energy transfer—a novel approach for sensitive detection of fluoroquinolones in water samples

Determination of emerging contaminants in environmental matrices

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