Environmental risk assessment of antibiotics in agroecosystems: ecotoxicological effects on aquatic microbial communities and dissemination of antimicrobial resistances and antibiotic biodegradation potential along the soil-water continuum

Martin-Laurent, Fabrice; Topp, Edward; Billet, Loren; Batisson, Isabelle; Malandain, Cédric; Besse-Hoggan, Pascale; Morin, Soizic; Artigas, Joan; Bonnineau, Chloé; Kergoat, Laura; Devers‐Lamrani, Marion; Pesce, Stéphane

doi:10.1007/s11356-019-05122-0

Cited by 41 publications

(20 citation statements)

References 92 publications

(76 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The potential of fungal members of the microbial community to degrade SUL in soils was documented by their enhanced activity (Chen et al, 2016) or increased proportion of fungal biomass in loamy sand soil (Gutiérrez et al, 2010) or in Chernozem Haplic and Phaeozem Greyic (Frková et al, 2020). Antibiotics are efficiently degraded by various soil microorganisms (Wang and Wang, 2018;Martin-Laurent et al, 2019), including resistant soil bacteria, which exhibit increased numbers due to environmental pollution (e.g., Fahrenfeld et al, 2014;Goodman and Gilman, 2011;Heuer et al, 2008). In our study, the second model for SUL includes K F and biomass of Gram-negative bacteria (Table 5) likely because these bacteria are more likely to acquire and spread plasmid-mediated antibiotic resistance in the environment (Stokes and Gillings, 2011).…”

Section: Estimation Of Dissipation Half-lives From K F Values Soil Pmentioning

confidence: 99%

How microbial community composition, sorption and simultaneous application of six pharmaceuticals affect their dissipation in soils

Kodešová

Chroňáková

Grabicová

et al. 2020

Science of The Total Environment

View full text Add to dashboard Cite

Soils groups according to basic soils properties and sorption of compounds matched. • Soils groups according to microbial community structure and half-lives corresponded. • Half-lives could be predicted using one microbial criterion and sorption coefficient. • Simultaneous application of all compounds mostly reduced their dissipation in soils. • The average increase in multiple-solute half-lives varied between 7 and 39%.

show abstract

Section: Estimation Of Dissipation Half-lives From K F Values Soil Pmentioning

confidence: 99%

How microbial community composition, sorption and simultaneous application of six pharmaceuticals affect their dissipation in soils

Kodešová

Chroňáková

Grabicová

et al. 2020

Science of The Total Environment

View full text Add to dashboard Cite

show abstract

“…A major concern regarding the general contamination of freshwaters (and other environmental compartments) by sulfonamides (and other antibiotics) is the increasing occurrence of microbial antibiotic resistance in the environment (Martin-Laurent et al, 2019). At sub-lethal doses, antibiotics exert a selection pressure that will promote the emergence and development of antibiotic resistance (for a complete review on antibiotic resistance mechanisms, see McDermott et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Environmental Concentrations of Sulfonamides Can Alter Bacterial Structure and Induce Diatom Deformities in Freshwater Biofilm Communities

et al. 2021

Self Cite

View full text Add to dashboard Cite

Since the early 1920s, the intensive use of antibiotics has led to the contamination of the aquatic environment through diffuse sources and wastewater effluents. The antibiotics commonly found in surface waters include sulfamethoxazole (SMX) and sulfamethazine (SMZ), which belong to the class of sulfonamides, the oldest antibiotic class still in use. These antibiotics have been detected in all European surface waters with median concentrations of around 50 ng L–1 and peak concentrations of up to 4–6 μg L–1. Sulfonamides are known to inhibit bacterial growth by altering microbial production of folic acid, but sub-lethal doses may trigger antimicrobial resistance, with unknown consequences for exposed microbial communities. We investigated the effects of two environmentally relevant concentrations (500 and 5,000 ng L–1) of SMZ and SMX on microbial activity and structure of periphytic biofilms in stream mesocosms for 28 days. Measurement of sulfonamides in the mesocosms revealed contamination levels of about half the nominal concentrations. Exposure to sulfonamides led to slight, transitory effects on heterotrophic functions, but persistent effects were observed on the bacterial structure. After 4 weeks of exposure, sulfonamides also altered the autotrophs in periphyton and particularly the diversity, viability and cell integrity of the diatom community. The higher concentration of SMX tested decreased both diversity (Shannon index) and evenness of the diatom community. Exposure to SMZ reduced diatom species richness and diversity. The mortality of diatoms in biofilms exposed to sulfonamides was twice that in non-exposed biofilms. SMZ also induced an increase in diatom teratologies from 1.1% in non-exposed biofilms up to 3% in biofilms exposed to SMZ. To our knowledge, this is the first report on the teratological effects of sulfonamides on diatoms within periphyton. The increase of both diatom growth rate and mortality suggests a high renewal of diatoms under sulfonamide exposure. In conclusion, our study shows that sulfonamides can alter microbial community structures and diversity at concentrations currently present in the environment, with unknown consequences for the ecosystem. The experimental set-up presented here emphasizes the interest of using natural communities to increase the ecological realism of ecotoxicological studies and to detect potential toxic effects on non-target species.

show abstract

“…Studies have shown that once the antibiotics reach the aquatic environment, due to their slow biodegradation, some of these drugs may persist in the environment for longer time due to bioaccumulation and biomagnification. Antibiotics in the natural environment, even in low quantities, can affect the survival, reproduction, and metabolism of aquatic organisms, as well as alter the structure of communities and ecosystem functions (Pereira et al 2015;Martin-Laurent et al 2019).…”

Section: Discussionmentioning

confidence: 99%

Identification and characterization of vancomycin-resistantStaphylococcus aureusin hospital wastewaters: evidence of horizontal spread of antimicrobial resistance

Girijan

Pillai

2021

Journal of Water and Health

View full text Add to dashboard Cite

Antibiotic resistance has become a major threat to human health around the world, but its spread through the aquatic environment has been often overlooked. This study aimed to determine the occurrence of vancomycin-resistant Staphylococcus aureus in hospital wastewaters and their transmission into public water bodies in Kerala, India. A total of 113 S. aureus were isolated from three hospital effluents in Kerala, India. Standard disc diffusion and the strip method were used for antibiotic susceptibility testing and minimum inhibitory concentration detection. Plasmid-mediated vancomycin resistance was confirmed by plasmid curing and conjugation; resistant genes were detected by the polymerase chain reaction (PCR). Nearly 76% of S. aureus isolates were resistant to β-lactams, chloramphenicol, macrolides, aminoglycosides, and glycopeptide class of antibiotics. Among the vancomycin-resistant Staphylococcus aureus (VRSA) isolates, the prevalence rates of vanA and vanB resistance-encoding genes were 46.5 and 59.3%, respectively. Through the broth mating method, vanA gene was successfully transferred from VRSA donor to vancomycin-sensitive S. aureus. The study strongly indicates the contamination of water bodies with antibiotic-resistant bacteria from hospital discharges, their dissemination and possible transfer to microbes in the aquatic environment, posing a serious threat for public health.

show abstract

Environmental risk assessment of antibiotics in agroecosystems: ecotoxicological effects on aquatic microbial communities and dissemination of antimicrobial resistances and antibiotic biodegradation potential along the soil-water continuum

Cited by 41 publications

References 92 publications

How microbial community composition, sorption and simultaneous application of six pharmaceuticals affect their dissipation in soils

How microbial community composition, sorption and simultaneous application of six pharmaceuticals affect their dissipation in soils

Environmental Concentrations of Sulfonamides Can Alter Bacterial Structure and Induce Diatom Deformities in Freshwater Biofilm Communities

Identification and characterization of vancomycin-resistantStaphylococcus aureusin hospital wastewaters: evidence of horizontal spread of antimicrobial resistance

Contact Info

Product

Resources

About