Environmental Risk Assessment (ERA) of diclofenac and ibuprofen: A public health perspective

Gamarra, Javier Salvador; Godoi, Ana F. L.; Vasconcelos, Eliane Carvalho de; Souza, Kennedy Medeiros Tavares de; Oliveira, Cíntia Mara Ribas de

doi:10.1016/j.chemosphere.2014.08.020

Cited by 37 publications

(15 citation statements)

References 29 publications

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“…However, many people use the inadequate method for lack of choice (34). Several authors had demonstrated that environmental contamination is an important consequence provided by improper disposal of medicines (33,(40)(41)(42). The present data corroborate the literature since the studied population reported that inappropriate disposal might result in critical problems, as soil and water contamination.…”

Section: Resultssupporting

confidence: 89%

Drug Disposal: Knowledge and Practice Among Pharmacy Students in Brazil

Viana

Magalhães

Santos

2019

Infarma

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Little is known about the knowledge of pharmacy students about the correct ways for drug disposal. Thus, this study aimed to evaluate the knowledge and practice of the pharmacy students about drug disposal. A descriptive and cross-sectional study was carried out with questionnaire application to 182 pharmacy students in Brazil between October and November of 2016. Data analyzes of the categorical variables were performed using descriptive statistics. The Chi-square test (X2) was used to evaluate the possible differences in the frequency between the form of medication discard according to dichotomous variables. Sixty-four point eight percent of the students reported discarding the drugs incorrectly, being that 48.8% do it in the household garbage. About 32% of the interviewers believed that the dispensation of the medicines beyond the exact amount for treatment is the main reason for the leftover. The chi-square test showed a higher correct disposal index from the 6th to the 10th period compared to the 1st to the 5th and according to previous guidance. Sixty-seven point six percent considered incorrect your way of drug disposal, 63.7% suggested the special collection as the correct destination and 84.6% reported knowing the consequences of improper disposal. This study showed that the majority of pharmacy students discards the overdue and/or unused drugs in an environmentally inadequate manner, but the correct disposal is more significant with the advance of the course period.

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Section: Resultssupporting

confidence: 89%

Drug Disposal: Knowledge and Practice Among Pharmacy Students in Brazil

Viana

Magalhães

Santos

2019

Infarma

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“…The contamination of aquatic systems by pharmaceutical residues is widely reported and constitutes a growing concern and risk for the environment and human health (Das et al, 2014;Gamarra et al, 2015;Huerta-Fontela et al, 2011). For instance, Loos et al, (2009) detected diclofenac in 83 % of their samples in European rivers.…”

Section: Introductionmentioning

confidence: 99%

Adsorption of pharmaceuticals onto activated carbon fiber cloths – Modeling and extrapolation of adsorption isotherms at very low concentrations

Fallou

Cimetière

Giraudet

et al. 2016

Journal of Environmental Management

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Activated carbon fiber cloths (ACFC) have shown promising results when applied to water treatment, especially for removing organic micropollutants such as pharmaceutical compounds. Nevertheless, further investigations are required, especially considering trace concentrations, which are found in current water treatment. Until now, most studies have been carried out at relatively high concentrations (mg L(-1)), since the experimental and analytical methodologies are more difficult and more expensive when dealing with lower concentrations (ng L(-1)). Therefore, the objective of this study was to validate an extrapolation procedure from high to low concentrations, for four compounds (Carbamazepine, Diclofenac, Caffeine and Acetaminophen). For this purpose, the reliability of the usual adsorption isotherm models, when extrapolated from high (mg L(-1)) to low concentrations (ng L(-1)), was assessed as well as the influence of numerous error functions. Some isotherm models (Freundlich, Toth) and error functions (RSS, ARE) show weaknesses to be used as an adsorption isotherms at low concentrations. However, from these results, the pairing of the Langmuir-Freundlich isotherm model with Marquardt's percent standard of deviation was evidenced as the best combination model, enabling the extrapolation of adsorption capacities by orders of magnitude.

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“…IBP was chosen as a model pollutant for this study due to its widespread availability as an over-the-counter Non-Steroidal Anti-inflammatory Drug (NSAID). IBP has been established as a potential public health risk [121] which has led to concern over the photochemical fate of the drug [6,7]. Removal of these and similar pollutants in low concentrations from water supplies is a vital challenge to maintaining high public health standards.…”

Section: Investigation Of Biocl Photocatalytic Degradation Mechanism mentioning

confidence: 99%

Application of BiOX Photocatalysts in Remediation of Persistent Organic Pollutants

2018

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Bismuth oxyhalides have recently gained attention for their promise as photocatalysts. Due to their layered structure, these materials present fascinating and highly desirable physicochemical properties including visible light photocatalytic capability and improved charge separation. While bismuth oxyhalides have been rigorously evaluated for the photocatalytic degradation of dyes and many synthesis strategies have been employed to enhance this property, relatively little work has been done to test them against pharmaceuticals and pesticides. These persistent organic pollutants are identified as emerging concerns by the EPA and effective strategies must be developed to combat them. Here, we review recent work directed at characterizing the nature of the interactions between bismuth oxyhalides and persistent organic pollutants using techniques including LC-MS/MS for the determination of photocatalytic degradation intermediates and radical scavenging to determine active species during photocatalytic degradation. The reported investigations indicate that the high activity of bismuth oxyhalides for the breakdown of persistent organic pollutants from water can be largely attributed to the strong oxidizing power of electron holes in the valence band. Unlike conventional catalysts like TiO2, these catalysts can also function in ambient solar conditions. This suggests a much wider potential use for these materials as green catalysts for industrial photocatalytic transformation, particularly in flow chemistry applications.

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Environmental Risk Assessment (ERA) of diclofenac and ibuprofen: A public health perspective

Cited by 37 publications

References 29 publications

Drug Disposal: Knowledge and Practice Among Pharmacy Students in Brazil

Drug Disposal: Knowledge and Practice Among Pharmacy Students in Brazil

Adsorption of pharmaceuticals onto activated carbon fiber cloths – Modeling and extrapolation of adsorption isotherms at very low concentrations

Application of BiOX Photocatalysts in Remediation of Persistent Organic Pollutants

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