Environmental‐relevant bisphenol A exposure promotes ovarian cancer stemness by regulating microRNA biogenesis
Sophia S. N. Lam,
Zeyu Shi,
Carman K. M. Ip
et al.
Abstract:Bisphenol A (BPA) is a ubiquitous environmental xenobiotic impacting millions of people worldwide. BPA has long been proposed to promote ovarian carcinogenesis, but the detrimental mechanistic target remains unclear. Cancer stem cells (CSCs) are considered as the trigger of tumour initiation and progression. Here, we show for the first time that nanomolar (environmentally relevant) concentration of BPA can markedly increase the formation and expansion of ovarian CSCs concomitant. This effect is observed in bot… Show more
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