Environmental polycyclic aromatic hydrocarbon exposure is associated with low back pain

Jiang, Chen; Liao, Yangjie; Luo, Mingjiang; Tang, Siliang; Huang, Jinshan; Chen, Rong; Xiao, Zhihong

doi:10.1007/s10653-023-01567-y

Cited by 5 publications

(1 citation statement)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Serum GGT has been used as a biomarker for oxidative stress in many epidemiologic studies (Chang et al, 2022;Li et al, 2023), usually, in relationship to environmental exposures (Chen et al, 2023b).…”

Section: Introductionmentioning

confidence: 99%

Exposure to phthalates and their alternatives in relation to biomarkers of inflammation and oxidative stress in adults: evidence from NHANES 2017–2018

Jin,

Cui,

et al. 2023

Environ Sci Pollut Res

View full text Add to dashboard Cite

Phthalates and their alternatives are considered signi cant environmental risk factors that potentially in uence in ammation and oxidative stress. However, their impact on biomarkers of in ammation and oxidative stress was inconsistent. This study aimed to explore the associations between phthalates and high-sensitivity C-reactive protein (hsCRP), gamma-glutamyl transferase (GGT), and white blood cell (WBC) counts, employing both univariate exposure and multivariate co-exposure models. For this analysis, a total of 1619 individuals aged 18 years and above, sourced from the National Health and Nutrition Examination Survey (NHANES) conducted between 2017 and 2018, were selected as subjects. We explored the associations between hsCRP, GGT, and WBC counts and eighteen different phthalate metabolites. Multiple linear regression analysis revealed signi cant associations between hsCRP and two speci c metabolites: MCNP (β = 0.060, P = 0.034) and MEHP (β = -0.054, P = 0.049). We observed negative correlations of MCOP, MCPP, MHBP, and MONP with GGT (β = -0.036, P = 0.027; β = -0.045, P = 0.019; β = -0.046, P = 0.023; β = -0.053, P = 0.001, respectively). Conversely, MEHHP and MEHTP exhibited positive correlations with GGT (β = 0.048, P = 0.011; β = 0.029, P = 0.009). Furthermore, MECPTP and MEHTP showed positive correlations with WBC (β = 0.011, P = 0.026; β = 0.017, P = 0.001). Notably, we identi ed a non-linear relationship between phthalates and in ammation and oxidative stress markers.The Bayesian kernel machine regression (BKMR) analysis demonstrated a negative joint effect of the phthalates mixture on GGT, particularly at lower concentrations. The BKMR model also found that MEOHP and MHiBP were negatively associated with GGT. In contrast, MEHHP showed a signi cant positive association with GGT. Moderating effect analysis suggested that increased dietary in ammatory index (DII), income-to-poverty ratio (PIR), age, BMI, and less physical activity strengthened the association between phthalates and in ammation and oxidative stress. These ndings contribute to a deeper understanding of the relationships between phthalates and in ammation and oxidative stress.

show abstract

Section: Introductionmentioning

confidence: 99%

Exposure to phthalates and their alternatives in relation to biomarkers of inflammation and oxidative stress in adults: evidence from NHANES 2017–2018

Jin,

Cui,

et al. 2023

Environ Sci Pollut Res

View full text Add to dashboard Cite

show abstract

Phenanthrene Elimination from Soil through the Activation of Peroxymonosulfate by Biogenically Derived Manganese Oxide

Jiang,

Zhang,

et al. 2024

Water Air Soil Pollut

View full text Add to dashboard Cite

Association of mixed polycyclic aromatic hydrocarbons exposure with oxidative stress in Korean adults

Ryu,

Hong

2024

Sci Rep

View full text Add to dashboard Cite

Polycyclic aromatic hydrocarbons (PAHs) are widespread pollutants associated with several adverse health effects and PAH-induced oxidative stress has been proposed as a potential mechanism. This study evaluated the associations of single and multiple PAHs exposure with oxidative stress within the Korean adult population, using serum gamma glutamyltransferase (GGT) as an oxidative stress marker. Data from the Second Korean National Environmental Health Survey (2012–2014) were analyzed. For analysis, 5225 individuals were included. PAH exposure was assessed with four urinary PAH metabolites: 1-hydroxyphenanthrene, 1-hydroxypyrene, 2-hydroxyfluorene, and 2-naphthol. After adjusting for age, sex, body mass index, drinking, passive smoking, and current smoking (model 1), as well as the presence of diabetes and hepatobiliary diseases (model 2), complex samples general linear model regression analyses for each metabolite revealed a significant positive association between Ln(1-hydroxyphenanthrene) and Ln(GGT) (model 1: β = 0.040, p < 0.01 and model 2: β = 0.044, p < 0.05). For the complete dataset (n = 4378), a significant positive association was observed between mixture of four urinary PAH metabolites and serum GGT in both the quantile g-computation and the Bayesian kernel machine regression analysis. Our study provides evidence for the association between mixed PAH exposure and oxidative stress.

show abstract

Environmental polycyclic aromatic hydrocarbon exposure is associated with low back pain

Cited by 5 publications

References 70 publications

Exposure to phthalates and their alternatives in relation to biomarkers of inflammation and oxidative stress in adults: evidence from NHANES 2017–2018

Exposure to phthalates and their alternatives in relation to biomarkers of inflammation and oxidative stress in adults: evidence from NHANES 2017–2018

Phenanthrene Elimination from Soil through the Activation of Peroxymonosulfate by Biogenically Derived Manganese Oxide

Association of mixed polycyclic aromatic hydrocarbons exposure with oxidative stress in Korean adults

Contact Info

Product

Resources

About