Environmental pollution and diabetes mellitus

El-Sikaily, Amany; Helal, M. A.

doi:10.13105/wjma.v9.i3.234

Cited by 2 publications

(2 citation statements)

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“…Chronic hyperglycemia is due to an inability of the body to consistently break down the glucose required to keep up with energy requirements because of peripheral insulin resistance. Peripheral insulin resistance results in a consequent reduction in the uptake of glucose by insulin-dependent glucose transporters (GLUT4), resulting in an increase in circulating glucose, and subsequent lipid oxidation due to impaired glucose intake [88].…”

Section: The Development Of T2dmentioning

confidence: 99%

“…The heavy metal arsenic (As) has been posited to have negative pancreatic and hepatic effects (Figure 4). A review identified that arsenic plays a role in inducing diabetes by altering tumor necrosis factor-α (TNF-α), GLUT4 and mitogen-activated protein kinase (MAPK) [88]. In a rodent study conducted by Liu et al, the control group of mice was shown to be affected by inorganic arsenic through pancreatic β-cell dysfunction with increased gluconeogenesis and oxidative damage in the liver [89].…”

Section: The Role Of Metals In Inducing Type 2 Diabetes Mellitusmentioning

confidence: 99%

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Environmental Pollution and the Risk of Developing Metabolic Disorders: Obesity and Diabetes

Khalil,

Akeblersane,

Khan

et al. 2023

IJMS

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To meet the increased need for food and energy because of the economic shift brought about by the Industrial Revolution in the 19th century, there has been an increase in persistent organic pollutants (POPs), atmospheric emissions and metals in the environment. Several studies have reported a relationship between these pollutants and obesity, and diabetes (type 1, type 2 and gestational). All of the major pollutants are considered to be endocrine disruptors because of their interactions with various transcription factors, receptors and tissues that result in alterations of metabolic function. POPs impact adipogenesis, thereby increasing the prevalence of obesity in exposed individuals. Metals impact glucose regulation by disrupting pancreatic β-cells, causing hyperglycemia and impaired insulin signaling. Additionally, a positive association has been observed between the concentration of endocrine disrupting chemicals (EDCs) in the 12 weeks prior to conception and fasting glucose levels. Here, we evaluate what is currently known regarding the link between environmental pollutants and metabolic disorders. In addition, we indicate where further research is required to improve our understanding of the specific effects of pollutants on these metabolic disorders which would enable implementation of changes to enable their prevention.

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Section: The Development Of T2dmentioning

confidence: 99%

Section: The Role Of Metals In Inducing Type 2 Diabetes Mellitusmentioning

confidence: 99%