Environmental Pollution: An Under-recognized Threat to Children’s Health, Especially in Low- and Middle-Income Countries

Suk, William A.; Ahanchian, Hamid; Asante, Kwadwo Ansong; Carpenter, David O.; Dı́az-Barriga, Fernando; Ha, Eun Hee; Huo, Xia; King, M.; Ruchirawat, Mathuros; Silva, Emerson Rodrigues da; Sly, Leith; Sly, Peter D.; Stein, Renato T.; Berg, Martin van den; Zar, Heather J.; Landrigan, Philip J.

doi:10.1289/ehp.1510517

Cited by 108 publications

(59 citation statements)

References 63 publications

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“…Indeed they appear to have a lower risk, perhaps uniquely for any environmental pollutants 34. However, given the long latency and the greater years of life yet to be lived by those exposed as children, it is highly likely that there will be more cases of mesothelioma in the future among those first exposed as children than those first exposed as adults.…”

Section: Discussionmentioning

confidence: 99%

Are children more vulnerable to mesothelioma than adults? A comparison of mesothelioma risk among children and adults exposed non-occupationally to blue asbestos at Wittenoom

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Are children more vulnerable to mesothelioma than adults? A comparison of mesothelioma risk among children and adults exposed non-occupationally to blue asbestos at Wittenoom

et al. 2018

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“…Exposure to persistent organic chemicals has been linked to cancer (25). One possibility of cancer prevention may involve the use of chemicals or dietary components to block, inhibit or reverse the development of cancer in normal or preneoplastic tissues.…”

Section: Chemoprevention By Xanthohumolmentioning

confidence: 99%

“…Exposure to environmental pollutants during vulnerable periods of life, i.e. during development and early childhood, can trigger more severe onset of non-communicable diseases later in life (25). Most importantly, the added stress of infectious diseases, poverty and malnutrition can compound the vulnerability to environmental chemical-mediated disease pathologies.…”

Section: In Vivo Evidence Of Nutritional Modulation Of Environmental mentioning

confidence: 99%

The role of nutrition in influencing mechanisms involved in environmentally mediated diseases

Hennig

Petriello

Gamble

et al. 2018

Reviews on Environmental Health

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AbstractHuman exposure to environmental contaminants such as persistent chlorinated organics, heavy metals, pesticides, phthalates, flame retardants, electronic waste and airborne pollutants around the world, and especially in Southeast Asian regions, are significant and require urgent attention. Given this widespread contamination and abundance of such toxins as persistent organic pollutants (POPs) in the ecosystem, it is unlikely that remediation alone will be sufficient to address the health impacts associated with this exposure. Furthermore, we must assume that the impact on health of some of these contaminants results in populations with extraordinary vulnerabilities to disease risks. Further exacerbating risk; infectious diseases, poverty and malnutrition are common in the Southeast Asian regions of the world. Thus, exploring preventive measures of environmental exposure and disease risk through new paradigms of environmental toxicology, optimal and/or healthful nutrition and health is essential. For example, folic acid supplementation can lower blood arsenic levels, and plant-derived bioactive nutrients can lower cardiovascular and cancer risks linked to pollutant exposure. Data also indicate that diets enriched with bioactive food components such as polyphenols and omega-3 polyunsaturated fatty acids can prevent or decrease toxicant-induced inflammation. Thus, consuming healthy diets that exhibit high levels of antioxidant and anti-inflammatory properties, is a meaningful way to reduce the vulnerability to non-communicable diseases linked to environmental toxic insults. This nutritional paradigm in environmental toxicology requires further study in order to improve our understanding of the relationship between nutrition or other lifestyle modifications and toxicant-induced diseases. Understanding mechanistic relationships between nutritional modulation of environmental toxicants and susceptibility to disease development are important for both cumulative risk assessment and the design and implementation of future public health programs and behavioral interventions.

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“…The adverse health consequences of exposure to environmental toxicants constitute a large and rapidly growing global problem, yet they receive insufficient attention in the global health and international development agendas (10). According to the World Health Organization (WHO), 23% of all global deaths are linked to the environment.…”

Section: The Need To Integrate and Share Datamentioning

confidence: 99%

The CEECHE: a practical approach for reducing exposures and disease outcomes in Central and Eastern Europe

Suk

2017

Reviews on Environmental Health

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Abstract While each region of the world faces unique challenges, environmental threats to vulnerable populations throughout Central and Eastern Europe (CEE) present a significant public health challenge. Environmental pollution is widespread, resulting from the consequences of rapid industrialization during the Soviet Union era. To help address these concerns, a meeting, sponsored in part by the National Institutes of Health (NIH)/National Institute of Environmental Health Sciences (NIEHS) Superfund Research Program (SRP), was convened in 1994. The meeting, “Hazardous Wastes – Exposure, Remediation, and Policy,” brought together representatives of the governments of seven countries in the region, scientists from the United States and Western Europe, and representatives from international organizations to explore hazardous waste problems in the region. Since 1994, the SRP and partners have been holding meetings throughout CEE to share important information regarding environmental health. The general sessions have shifted from a focus on describing the problems in each country related to hazardous waste, exposure assessment, risk reduction, and risk communication, to an exchange of information to better define links between health and the environment and strategies to improve regional problems. The 1994 meeting and subsequent meetings raised issues such as heavy metal contamination, exposures from hazardous waste, and pollution caused by deficiencies in disposal of waste overall. Research priorities that were identified included development of reliable biomarkers, better understanding of the relationship between nutrition and chemical toxicity, more epidemiological studies in CEE, better methods of environmental data analysis, and development of remediation tools. Here, we review examples of research from current SRP grantees that address many of these issues. In 2004, the first official Central and Eastern European Conference on Health and the Environment (CEECHE) was held, and has been held biannually at venues across CEE. The CEECHE provides a forum for researchers and engineers, and organizations with diverse professional expertise and backgrounds, to jointly examine pressing environment and health issues, engage in cooperative research, and develop and disseminate innovative prevention strategies for addressing these issues. The CEECHE facilitates more intentional integration of disciplines to achieve a fundamental understanding of biological, environmental, and engineering processes and exploit this knowledge to contribute to solving environmental exposure-related issues. Critical to the CEECHE mission is the participation of trainees and junior scientists who will share their data and engage broadly with the scientific community. Scientific inquiry that supports a paradigm whereby knowledge gained through understanding disease processes resulting from environmental exposures would further our understanding of potential human health effects, and provide a creative, holistic approach to integrate seemingly discrete biological systems and geological, ecological and human health risk assessments into more comprehensive models. Such models will be discussed which advance the mission of reducing the public health burden of hazardous substances through interdisciplinary research and training.

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Environmental Pollution: An Under-recognized Threat to Children’s Health, Especially in Low- and Middle-Income Countries

Cited by 108 publications

References 63 publications

Are children more vulnerable to mesothelioma than adults? A comparison of mesothelioma risk among children and adults exposed non-occupationally to blue asbestos at Wittenoom

Are children more vulnerable to mesothelioma than adults? A comparison of mesothelioma risk among children and adults exposed non-occupationally to blue asbestos at Wittenoom

The role of nutrition in influencing mechanisms involved in environmentally mediated diseases

The CEECHE: a practical approach for reducing exposures and disease outcomes in Central and Eastern Europe

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