Environmental Pollutants: Effects on the Immune System and Resistance to Infectious Disease

Caren, Linda D.

doi:10.2307/1308220

Cited by 24 publications

(15 citation statements)

References 21 publications

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“…For example, malnourished mice were more sensitive to virus exposure and environmental chemicals (a plant growth yls). Since several commercial plant growth, immune system, these results cast doubt on t procedures in which factors are studied indii Many biological and physical variables affecting an animal's capacity to grow and reproduce have been identified (1). Efficient study and modeling of large numbers of variables simultaneously in a biological system pose difficult problems.…”

mentioning

confidence: 99%

“…While the possibility of added danger from such exposure has long been suspected, the use of fractional factorial designs offers an op-+ Many studies have shown the effectiveness of electrical stimulation of the periventricular gray matter (PVG) (1)(2)(3)(4)(5)(6) and various areas of the thalamus or internal capsule (7)(8)(9) for relief of chronic pain in humans. The most popular neurochemical hypothesis proposed to explain this phenomenon suggests that the effect of stimulation-produced analgesia (SPA) in humans is mediated by release of endogenous opiates.…”

mentioning

confidence: 99%

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Toxicant-Disease-Environment Interactions Associated with Suppression of Immune System, Growth, and Reproduction

Porter¹,

Hinsdill²,

Fairbrother³

et al. 1984

Science

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The effects of marginal malnourishment , infections, and environmental chemicals on growth and reproductive success in Swiss-Webster white mice and wild deer mice were studied with fractional factorial designs. Interaction effects were discovered. For example, malnourished mice were more sensitive to virus exposure and environmental chemicals (a plant growth regulator or polychlorinated biphenyls). Since several commercial plant growth regulators also appear to suppress the immune system, these results cast doubt on the adequacy of current toxicity testing procedures in which factors are studied individually and not in combination.

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mentioning

confidence: 99%

mentioning

confidence: 99%

Toxicant-Disease-Environment Interactions Associated with Suppression of Immune System, Growth, and Reproduction

Porter¹,

Hinsdill²,

Fairbrother³

et al. 1984

Science

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“…The first is called disease‐free because the disease disappears, while the second is called endemic because the disease persists. As seen above, some medical evidence highlights the negative effects of pollution ( P ) on the immune system (Caren ; Bauer et al . ) and supports the theoretical assumption of

β

and

γ

as increasing and decreasing functions of P , respectively.…”

Section: Fundamentalsmentioning

confidence: 99%

Pollution and infectious diseases

Bosi

Desmarchelier

2018

Int J of Economic Theory

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Recent empirical contributions highlight the negative impact of pollution on labor supply. This relationship is explained by two mechanisms: first, pollution modifies agents’ work–leisure trade‐off as it deteriorates their working conditions (incentive effect); and second, a polluted environment is likely to generate more frequent epidemic outbreaks and to affect agents’ immune systems (health effect). Bosi et al. () explore the aggregate consequences of the incentive effect and show that it can generate endogenous fluctuations in the economic activity. The present paper focuses on the health effect as we study a Ramsey model augmented with the spread of infectious disease. We find that industrial pollution may generate limit cycles around an endemic steady state. More precisely, the economic system may undergo a transcritical bifurcation followed by two Hopf bifurcations near this steady state.

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“…Together, nonspecific and specific immunity enable the host to resist invasion by foreign organisms and remove worn-out &dquo;self' components (Caren, 1981).…”

Section: Introductionmentioning

confidence: 99%

“…Lead, cadmium, mercury, cobalt, arsenic, beryllium and silica are some of the metals which have been examined for their effects on the immune system (Becker et al, 1962;Koller et al, 1975;Weening et al, 1978;Faith et al, 1980;Bemaudin et al, 1980;Blakley et al, 1981;Caren, 1981;Koller, 1982;Treagen, 1983). In mice, a dose of 100 or 250 micrograms of soluble lead nitrate administered daily for 30 days resulted in a highly significant increase in susceptibility to infection with a gram-negative bacterial pathogen.…”

Section: Introductionmentioning

confidence: 99%