Environmental photochemical fate of pesticides ametryn and imidacloprid in surface water (Paranapanema River, São Paulo, Brazil)

Rocha, Cleonice; Lastre-Acosta, Arlen Mabel; Parizi, Marcela Prado Silva; Teixeira, Antônio Carlos Silva Costa

doi:10.1007/s11356-021-17991-5

“…However, the widespread use of pesticides, including imidacloprid, has resulted in colony collapse disorder (CCD), causing severe impacts on the beekeeping industry and ecological balance (Mahé et al, 2021 ). Studies have shown that imidacloprid is applied as a seed coating (Simon-Delso et al, 2015 ) and accumulates in the plant (Dively and Kamel, 2012 ;Rocha et al, 2022 ), exposing non-target bees to imidacloprid residues during pollen and nectar collection (Tong et al, 2018 ). Even low levels of systemic imidacloprid cause sublethal effects in adult bees, including neurotoxicity (Belzunces et al, 2012 ), behavioural changes (Karahan et al, 2015 ;Medrzycki et al, 2003 ), reproductive impairment (Chaimanee et al, 2016 ), reduced immunity (Pettis et al, 2013 ), apoptosis and autophagy (Carneiro et al, 2022 ), and shortened lifespan (Anderson and Harmon-Threatt, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Imidacloprid disrupts larval molting regulation and nutrient energy metabolism, causing developmental delay in honey bee Apis mellifera

Li

¹

,

Wang

²

,

Qin

³

et al. 2024

eLife

1

0

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Imidacloprid is a global health threat that severely poisons the economically and ecologically important honeybee pollinators, Apis mellifera. However, its effects on developing bee larvae remain largely unknown. Our pilot study found that imidacloprid causes developmental delay in bee larvae, but its toxicological mechanisms are not yet fully understood. In this study, we exposed bee larvae to imidacloprid at environmentally relevant concentrations of 0.7, 1.2, 3.1, and 377 ppb. A significant dose-dependent delay in the larval development was observed, including reductions in body mass, width, and growth index; however, imidacloprid did not affect larval survival and food consumption. Predominant toxicological effects induced by high concentrations of imidacloprid (377 ppb) included disruption of neural transmission, induction of oxidative stress and gut structural damage and apoptosis, inhibition of developmental regulatory hormones and genes, disruption of proteolysis, amino acid transport, protein synthesis, carbohydrate catabolism, oxidative phosphorylation, and glycolysis energy production. In parallel, we observed that the larvae employed antioxidant defense and P450 detoxification mechanisms to counteract imidacloprid. Ultimately, this study provides the first evidence that environmental exposure to imidacloprid can retard bee larval growth and development by disrupting molting regulation and limiting the metabolism and utilization of dietary nutrients and energy. These findings have broader reference implications for studies assessing pesticide hazards to other juvenile animals.

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“…However, the widespread use of pesticides, including imidacloprid, has resulted in colony collapse disorder (CCD), causing severe impacts on the beekeeping industry and ecological balance (Mahé et al, 2021). Studies have shown that imidacloprid is applied as a seed coating (Simon-Delso et al, 2015) and accumulates in the plant (Dively and Kamel, 2012; Rocha et al, 2022), exposing non-target bees to imidacloprid residues during pollen and nectar collection (Tong et al, 2018). Even low levels of systemic imidacloprid cause sublethal effects in adult bees, including neurotoxicity (Belzunces et al, 2012), behavioural changes (Karahan et al, 2015; Medrzycki et al, 2003), reproductive impairment (Chaimanee et al, 2016), reduced immunity (Pettis et al, 2013), apoptosis and autophagy (Carneiro et al, 2022), and shortened lifespan (Anderson and Harmon-Threatt, 2021).…”

Section: Introductionmentioning

confidence: 99%

Imidacloprid disrupts larval molting regulation and nutrient energy metabolism, causing developmental delay in honey beeApis mellifera

Li¹,

Wang²,

Qin³

et al. 2023

Preprint

0

View full text Add to dashboard Cite

Imidacloprid is a global health threat that severely poisons the economically and ecologically important honeybee pollinators, Apis mellifera. However, its effects on developing bee larvae remain largely unknown. Our pilot study found that imidacloprid causes developmental delay in bee larvae, but its toxicological mechanisms are not yet fully understood. In this study, we exposed bee larvae to imidacloprid at environmentally relevant concentrations of 0.7, 1.2, 3.1, and 377 ppb. A significant dose-dependent delay in the larval development was observed, including reductions in body mass, width, and growth index; however, imidacloprid did not affect larval survival and food consumption. Predominant toxicological effects induced by high concentrations of imidacloprid (377 ppb) included disruption of neural transmission, induction of oxidative stress and gut structural damage and apoptosis, inhibition of developmental regulatory hormones and genes, disruption of proteolysis, amino acid transport, protein synthesis, carbohydrate catabolism, oxidative phosphorylation, and glycolysis energy production. In parallel, we observed that the larvae employed antioxidant defense and P450 detoxification mechanisms to counteract imidacloprid. Ultimately, this study provides the first evidence that environmental exposure to imidacloprid can retard bee larval growth and development by disrupting molting regulation and limiting the metabolism and utilization of dietary nutrients and energy. These findings have broader reference implications for studies assessing pesticide hazards to other juvenile animals.

show abstract

“…However, the widespread use of pesticides, including imidacloprid, has resulted in colony collapse disorder (CCD), causing severe impacts on the beekeeping industry and ecological balance (Mahé et al, 2021 ). Studies have shown that imidacloprid is applied as a seed coating (Simon-Delso et al, 2015 ) and accumulates in the plant (Dively and Kamel, 2012 ;Rocha et al, 2022 ), exposing non-target bees to imidacloprid residues during pollen and nectar collection (Tong et al, 2018 ). Even low levels of systemic imidacloprid cause sublethal effects in adult bees, including neurotoxicity (Belzunces et al, 2012 ), behavioural changes (Karahan et al, 2015 ;Medrzycki et al, 2003 ), reproductive impairment (Chaimanee et al, 2016 ), reduced immunity (Pettis et al, 2013 ), apoptosis and autophagy (Carneiro et al, 2022 ), and shortened lifespan (Anderson and Harmon-Threatt, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Imidacloprid disrupts larval molting regulation and nutrient energy metabolism, causing developmental delay in honey bee Apis mellifera

Li,

Wang,

Qin

et al. 2023

Preprint

0

View full text Add to dashboard Cite

Imidacloprid is a global health threat that severely poisons the economically and ecologically important honeybee pollinator, Apis mellifera. However, its effects on developing bee larvae remain largely unexplored. Our pilot study showed that imidacloprid causes developmental delay in bee larvae, but the underlying toxicological mechanisms remain incompletely understood. In this study, we exposed bee larvae to imidacloprid at environmentally relevant concentrations of 0.7, 1.2, 3.1, and 377 ppb. There was a marked dose-dependent delay in larval development, characterized by reductions in body mass, width, and growth index. However, imidacloprid did not affect on larval survival and food consumption. The primary toxicological effects induced by elevated concentrations of imidacloprid (377 ppb) included inhibition of neural transmission gene expression, induction of oxidative stress, gut structural damage, and apoptosis, inhibition of developmental regulatory hormones and genes, suppression of gene expression levels involved in proteolysis, amino acid transport, protein synthesis, carbohydrate catabolism, oxidative phosphorylation, and glycolysis energy production. In addition, we found that the larvae may use antioxidant defenses and P450 detoxification mechanisms to mitigate the effects of imidacloprid. Ultimately, this study provides the first evidence that environmentally exposed imidacloprid can affect the growth and development of bee larvae by disrupting molting regulation and limiting the metabolism and utilization of dietary nutrients and energy. These findings have broader implications for studies assessing pesticide hazards in other juvenile animals.

show abstract

Environmental photochemical fate of pesticides ametryn and imidacloprid in surface water (Paranapanema River, São Paulo, Brazil)

Cited by 13 publications

References 67 publications

Imidacloprid disrupts larval molting regulation and nutrient energy metabolism, causing developmental delay in honey bee Apis mellifera

Imidacloprid disrupts larval molting regulation and nutrient energy metabolism, causing developmental delay in honey bee Apis mellifera

Imidacloprid disrupts larval molting regulation and nutrient energy metabolism, causing developmental delay in honey beeApis mellifera

Imidacloprid disrupts larval molting regulation and nutrient energy metabolism, causing developmental delay in honey bee Apis mellifera

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