Environmental parameters associated with incidence and transmission of pathogenic <i>Vibrio spp</i>.

Brumfield, Kyle D.; Usmani, Moiz; Chen, Kristine M.; Gangwar, Mayank; Jutla, Antarpreet; Huq, Anwar; Colwell, Rita R.

doi:10.1111/1462-2920.15716

Cited by 70 publications

(81 citation statements)

References 277 publications

(449 reference statements)

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“…are modulated by environmental parameters, namely ambient weather and climatic processes. For example, it is now known that coastal waters provide an ecological niche for pathogenic Vibrio spp ., including Vibrio parahaemolyticus , Vibrio vulnificus , and V. cholerae (Brumfield et al., 2021). Furthermore, Vibrio spp .…”

Section: Editorialmentioning

confidence: 99%

“…are commensal to copepods, a zooplankton comprising a significant component of aquatic fauna that feeds on phytoplankton in coastal waters (Tamplin et al, 1990). In fact, copepods are a major host of V. cholerae, sufficiently significant to be considered a vector (Brumfield et al, 2021). In summary, vibrios in the environment are strongly associated with the ecological and climate/weather processes, such as flooding (Khan et al, 2019;Koelle et al, 2005), sea surface temperature (Constantin de Magny et al, 2008;Lobitz et al, 2000), zooplankton (Huq et al, 1983(Huq et al, , 1996, phytoplankton (R. Colwell & Huq, 2001); salinity (Miller et al, 1982); regional hydrology such as river flows (Akanda et al, 2009), coastal ecological processes such as planktonic growths (A.…”

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confidence: 99%

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Predictive Intelligence for Cholera in Ukraine?

et al. 2022

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Cholera, an ancient waterborne diarrheal disease, remains a threat to public health, especially when climate/weather processes, microbiological parameters, and sociological determinants intersect with population vulnerabilities of loss of access to safe drinking water and sanitation infrastructure. The ongoing war in Ukraine has either damaged or severely crippled civil infrastructure, following which the human population is at risk of health disasters. This editorial highlights a perspective on using predictive intelligence to combat potential (and perhaps impending) cholera outbreaks in various regions of Ukraine. Reliable and judicious use of existing earth observations inspired mathematical algorithms integrating heuristic understanding of microbiological, sociological, and weather parameters have the potential to save or reduce the disease burden.

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Section: Editorialmentioning

confidence: 99%

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Predictive Intelligence for Cholera in Ukraine?

et al. 2022

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“…The bacterium V. vulnificus is an opportunistic and formidable human pathogen that has a worldwide distribution in a variety of marine and estuarine environments ( 1 , 2 ). In humans, V. vulnificus may cause a range of illnesses including gastroenteritis, necrotizing fasciitis, and septicemia ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Variable Freshwater Influences on the Abundance of Vibrio vulnificus in a Tropical Urban Estuary

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James-Davis

Carlo

et al. 2022

Appl Environ Microbiol

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To better understand the controls on the opportunistic human pathogen Vibrio vulnificus in warm tropical waters, we conducted a year-long investigation in the Ala Wai Canal, a channelized estuary in Honolulu, HI. The abundance of V. vulnificus as determined by qPCR of the hemolysin gene ( vvhA ), varied spatially and temporally nearly four orders of magnitude (≤ 3 to 14,000 mL −1 ). Unlike in temperate and subtropical systems, temperatures were persistently warm (19–31°C) and explained little of the variability in V. vulnificus abundance. Salinity (1–36 ppt) had a significant, but non-linear, relationship with V. vulnificus abundance with highest vvhA concentrations (> 2,500 mL −1 ) observed only at salinities from 7 to 22 ppt. V. vulnificus abundances were lower on average in the summer dry season when waters were warmer but more saline. Highest canal-wide average abundances were observed during a time of modest rainfall when moderate salinities and elevated concentrations of reduced nitrogen species and silica suggested a groundwater influence. Distinguishing the abundances of two genotypes of V. vulnificus (C-type and E-type) suggest that C-type strains, which are responsible for most human infections, were usually less abundant (25% on average), but their relative contribution was greater at higher salinities, suggesting a broader salinity tolerance. Generalized regression models suggested up to 67% of sample-to-sample variation in log-transformed V. vulnificus abundance was explained (n = 202) using the measured environmental variables, and up to 97% of the monthly variation in canal-wide average concentrations (n = 13) was explained with the best subset of four variables. IMPORTANCE Our data illustrate that, in the absence of strong seasonal variation in water temperature in the tropics, variation in salinity driven by rainfall becomes a primary controlling variable on V. vulnificus abundance. There is thus a tendency for a rainfall-driven seasonal cycle in V. vulnificus abundance that is inverted from the temperature-driven seasonal cycle at higher latitudes. However, stochasticity in rainfall and its non-linear, indirect effects on V. vulnificus concentration means that high abundances can occur at any location in the canal at any time of year, making it challenging to predict concentrations of this pathogen at high temporal or spatial resolution. Much of the variability in canal-wide average concentrations, on the other hand, was explained by a few variables that reflect the magnitude of freshwater input to the system, suggesting that relative risk of exposure to this pathogen could be predicted as an average for the system.

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“…An array of environmental conditions have previously been associated with the presence and abundance of V. parahaemolyticus in estuarial environments ( DePaola et al, 2003 ; Turner et al, 2014 ; Johnson, 2015 ; Paranjpye et al, 2015 ; Davis et al, 2017 ; Hartwick et al, 2019 ; Brumfield et al, 2021 ). For example, water temperature is used as the primary environmental input in the U.S Food and Drug Administration’s risk assessment for V. parahaemolyticus in oysters ( USFDA, 2005 ).…”

Section: Introductionmentioning

confidence: 99%

Nested Spatial and Temporal Modeling of Environmental Conditions Associated With Genetic Markers of Vibrio parahaemolyticus in Washington State Pacific Oysters

et al. 2022

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The Pacific Northwest (PNW) is one of the largest commercial harvesting areas for Pacific oysters (Crassostrea gigas) in the United States. Vibrio parahaemolyticus, a bacterium naturally present in estuarine waters accumulates in shellfish and is a major cause of seafood-borne illness. Growers, consumers, and public-health officials have raised concerns about rising vibriosis cases in the region. Vibrio parahaemolyticus genetic markers (tlh, tdh, and trh) were estimated using an most-probable-number (MPN)-PCR technique in Washington State Pacific oysters regularly sampled between May and October from 2005 to 2019 (N = 2,836); environmental conditions were also measured at each sampling event. Multilevel mixed-effects regression models were used to assess relationships between environmental measures and genetic markers as well as genetic marker ratios (trh:tlh, tdh:tlh, and tdh:trh), accounting for variation across space and time. Spatial and temporal dependence were also accounted for in the model structure. Model fit improved when including environmental measures from previous weeks (1-week lag for air temperature, 3-week lag for salinity). Positive associations were found between tlh and surface water temp, specifically between 15 and 26°C, and between trh and surface water temperature up to 26°C. tlh and trh were negatively associated with 3-week lagged salinity in the most saline waters (> 27 ppt). There was also a positive relationship between tissue temperature and tdh, but only above 20°C. The tdh:tlh ratio displayed analogous inverted non-linear relationships as tlh. The non-linear associations found between the genetic targets and environmental measures demonstrate the complex habitat suitability of V. parahaemolyticus. Additional associations with both spatial and temporal variables also suggest there are influential unmeasured environmental conditions that could further explain bacterium variability. Overall, these findings confirm previous ecological risk factors for vibriosis in Washington State, while also identifying new associations between lagged temporal effects and pathogenic markers of V. parahaemolyticus.

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Environmental parameters associated with incidence and transmission of pathogenic Vibrio spp.

Abstract: Environmental parameters associated with incidence and transmission of pathogenic Vibrio spp.

Cited by 70 publications

References 277 publications

Predictive Intelligence for Cholera in Ukraine?

Predictive Intelligence for Cholera in Ukraine?

Variable Freshwater Influences on the Abundance of Vibrio vulnificus in a Tropical Urban Estuary

Nested Spatial and Temporal Modeling of Environmental Conditions Associated With Genetic Markers of Vibrio parahaemolyticus in Washington State Pacific Oysters

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