Environmental-level exposure to metals and metal-mixtures associated with spirometry-defined lung disease in American Indian adults: Evidence from the Strong Heart Study

Sobel, Marisa; Navas‐Acien, Ana; Powers, Martha; Grau-Pérez, María; Goessler, Walter; Best, Lyle G.; Umans, Jason G.; Oelsner, Elizabeth C.; Podalanczuk, Ana; Sanchez, Tiffany R.

doi:10.1016/j.envres.2021.112194

Cited by 22 publications

(10 citation statements)

References 56 publications

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“…There was a study in American Indian adults showed that Mo was associated with a decrease in FVC%, and Mo was the most in uential metal in restrictive ventilatory lung disease among diabetics (Sobel et al 2022). Whereas, in our study, Mo and Pb showed a potential protective effect.…”

Section: Discussioncontrasting

confidence: 58%

Association of multi-heavy metals exposure and lung function in a typical rural cohort of Northwest China

Zheng

Tian

et al. 2022

Preprint

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Background Heavy metal exposure is associated with decreased lung function, but the relationship between metals co-exposure and lung function in rural areas of northwest China remains unclear. Therefore, the purpose of this study is to explore the effects of single or co-exposure of heavy metals on lung function in a rural cohort of northwest China. Methods All participants were recruited from the Dongdagou-Xinglong (DDG-XL) rural cohort of Gansu province. Urine levels of 10 common heavy metals were detected, including cobalt (Co), nickel (Ni), molybdenum (Mo), cadmium (Cd), stibium (Sb), copper (Cu), zinc (Zn), mercury (Hg), lead (Pb) and manganese (Mn). The lung function was detected by measuring percentages of predicted forced vital capacity (FVC%) and forced expiratory volume in one second (FEV1%) as well as the ratio of FEV1/FVC. We also analyzed the association between heavy metals and pulmonary ventilation dysfunction (PVD). Restricted cubic spline, logistic regression, linear regression and bayesian kernel machine regression (BKMR) were used to analyze the relationship between heavy metals exposure and lung function. Results Finally, a total of 382 participants were included in this study with the average age of 56.69 ± 7.32 years, 82.46% of them used solid fuels for heating and cooking. Logistic regression analysis showed that higher concentration of Hg, Mn, Sb and lower Mo may be risk factors for PVD. And linear regression showed that FEV1% and FVC% were negatively correlated with Sb, Hg, Mn, but positively correlated with Mo. Through BKMR model, we found the lung function decreased with the increase of heavy metals concentration. In addition, Hg and Mn made an enormous contribution to the decline of lung function. Simultaneously, subgroup analyses showed that the males, the people with BMI ≥ 24kg/m2 and used solid fuels showed a higher risk of PVD when exposed to Co, Zn and Hg. Conclusions This study found that heavy metals exposure were associated with impairment of lung function regardless of single exposure or co-exposure, particularly for Hg and Mn.

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Section: Discussioncontrasting

confidence: 58%

Association of multi-heavy metals exposure and lung function in a typical rural cohort of Northwest China

Zheng

Tian

et al. 2022

Preprint

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“…Some studies have shown that obesity signi cantly interferes with respiratory function by reducing lung volume, especially expiratory reserve and functional residual volume (Mafort et al 2016). There is evidence that restrictive PVD usually shows a decrease in FEV1 and a constant or slight increase in FEV1/FVC (Sobel et al 2022). In this study, we mainly showed that heavy metals had adverse effects on restrictive PVD, but the relation of heavy metals exposure with lung function indexes was not obvious.…”

Section: Discussionmentioning

confidence: 56%

The association between multi-heavy metals exposure and lung function in a typical rural population of Northwest China

Zheng

Tian

et al. 2023

Environ Sci Pollut Res

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Background: Heavy metal exposure is associated with decreased lung function, but the relationship between metals co-exposure and lung function in rural areas of northwest China remains unclear. Therefore, the purpose of this study is to explore the effects of single or co-exposure of heavy metals on lung function in a rural cohort of northwest China.Methods: All participants were recruited from the Dongdagou-Xinglong (DDG-XL) rural cohort of Gansu province. Urine levels of 10 common heavy metals were detected, including cobalt (Co), nickel (Ni), molybdenum (Mo), cadmium (Cd), stibium (Sb), copper (Cu), zinc (Zn), mercury (Hg), lead (Pb) and manganese (Mn). The lung function was detected by measuring percentages of predicted forced vital capacity (FVC%) and forced expiratory volume in one second (FEV1%) as well as the ratio of FEV1/FVC. We also analyzed the association between heavy metals and pulmonary ventilation dysfunction (PVD).Restricted cubic spline, logistic regression, linear regression and Bayesian kernel machine regression (BKMR) were used to analyze the relationship between heavy metals exposure and lung function.Results: Finally, a total of 382 participants were included in this study with the average age of 56.69 ± 7.32 years, and 82.46% of them used solid fuels for heating and cooking. Logistic regression analysis showed that the higher concentration of Hg, Mn, Sb and lower Mo may be risk factors for PVD. We found that FEV1% and FVC% were negatively correlated with Sb, Hg, Mn, but positively correlated with Mo.Through BKMR model, we found the lung function decreased with the increase of heavy metals concentration. In addition, Hg and Mn made an enormous contribution to the decline of lung function. In subgroup analysis showed that the males, the people with BMI ≥ 24kg/m 2 and used solid fuels showed a higher risk of PVD when exposed to Co, Zn and Hg.Conclusions: Our results suggested that the heavy metals exposure were associated with impairment of lung function regardless of single exposure or co-exposure, particularly for Hg and Mn.

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“…Since the effect of Tu has historically been assessed in factory workers through welding processes, which involves the potential hazards for inhalation exposures that may lead to acute or chronic respiratory diseases(Meo & Al-Khlaiwi, 2003). To our best knowledge, only one recent study has taken Tu in a general population of American Indian adults, in both models of single metals and metal-mixtures, associations for Tu were mostly null, with no consistent pattern of relationship for Tu across the different spirometry endpoints(Sobel et al, 2022). Currently, there is no consensus regarding the association of Tu with lung function parameters, and this is the rst study to be conducted in a general population of children, more epidemiological and toxicological evidences are warranted.Unexpectedly, Ba was found to be positively associated with lung function metrics.…”

mentioning

confidence: 92%

“…Several rat models also provided supportive evidence that exposure to Cd could alter lung structure and function(Lai & Diamond, 1992;Surolia et al, 2015). Epidemiology researches have frequently indicated that Cd exposure was linked with impaired pulmonary function in occupational workers(Moitra et al, 2013;Moitra et al, 2015), general adults(Sobel et al, 2022;Yoon et al, 2015), and smokers(Mannino et al, 2004;Rokadia & Agarwal, 2013), but there have been few studies on children. PAHs) and other metals, therein Pb and Hg, in multivariate regressions(Feng et al, 2022).Therefore, the methodology differences may explain some of our discrepant results.…”

mentioning

confidence: 97%

Independent and combined associations of multiple-heavy-metal exposure with lung function: a population-based study in US children

Chen

Zhao

et al. 2023

Environ Geochem Health

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Background: Previous research has found relationships between some single metals and lung function parameters. However, the role of simultaneous multi-metal exposure is poorly understood. The crucial period throughout childhood, when people are most susceptible to environmental dangers, has also been largely ignored. The study aimed to evaluate the joint and individual associations of 12 selected urinary metals with pediatric lung function measures using multipollutant approaches.Methods: A total of 1227 children aged 6-17 years from the National Health and Nutrition Examination Survey database of the 2007-2012 cycles were used. The metal exposure indicators were 12 urine metals adjusted for urine creatinine, including Arsenic (As), Barium (Ba), Cadmium (Cd), Caesium (Cs), Cobalt (Co), Mercury (Hg), Molybdenum (Mo), Lead (Pb), Antimony (Sb), Thallium (Tl), Tu (Tungsten), and Urtiam (Ur). The outcomes of interest were lung function indices including the 1st second of a forceful exhalation (FEV 1 ), forced vital capacity (FVC), forced expiratory ow between 25% and 75% of vital capacity (FEF 25-75% ), and peak expiratory ow (PEF). Multivariate linear regression, quantile gcomputation (QG-C), and Bayesian kernel machine regression models (BKMR) were adopted.Results: A signi cantly negative overall effects of metal mixtures on all four lung function parameters were observed. Pb had the largest negative contribution to the negative associations, and Pb's relationship with lung function metrics showed to be nonlinear, with an approximate "L" shape. Potential interactions between Pb and Cd in lung function decline were observed. Whereas Ba was positively associated with lung function metrics. Conclusion: Metal mixtures were negatively associated with pediatric lung function. Pb might be crucial elements. Our ndings highlight the need for prioritizing children's environmental health to protect them from later respiratory disorders and to guide future research into the toxic mechanisms of metal-mediated lung function injury in the pediatric population.

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Environmental-level exposure to metals and metal-mixtures associated with spirometry-defined lung disease in American Indian adults: Evidence from the Strong Heart Study

Cited by 22 publications

References 56 publications

Association of multi-heavy metals exposure and lung function in a typical rural cohort of Northwest China

Association of multi-heavy metals exposure and lung function in a typical rural cohort of Northwest China

The association between multi-heavy metals exposure and lung function in a typical rural population of Northwest China

Independent and combined associations of multiple-heavy-metal exposure with lung function: a population-based study in US children

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