Environmental influences on childhood asthma: Climate change

Biagioni, Benedetta; Cecchi, Lorenzo; D’Amato, Gennaro; Annesi‐Maesano, Isabella

doi:10.1111/pai.13961

Cited by 10 publications

(5 citation statements)

References 92 publications

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“…Climate change can play a critical role in the onset, spread, and modifi cation of infectious respiratory diseases, which are a signifi cant asthma trigger. 35…”

Section: Wildfi Resmentioning

confidence: 99%

“…Climate change is a key environmental factor contributing to the increased prevalence and severity of allergic respiratory diseases in children. 35 It is recognized as one of the most dangerous threats to children's health and well-being. 9 Negative impacts of climate change experienced during childhood can have widespread, lifelong consequences, including chronic disease and problems with both physical development and learning.…”

Section: Childrenmentioning

confidence: 99%

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Climate change and its impact on asthma

Arceneaux,

Gregory

2024

The Nurse Practitioner

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“…Climate change can play a critical role in the onset, spread, and modifi cation of infectious respiratory diseases, which are a signifi cant asthma trigger. 35…”

Section: Wildfi Resmentioning

confidence: 99%

Section: Childrenmentioning

confidence: 99%

Climate change and its impact on asthma

Arceneaux,

Gregory

2024

The Nurse Practitioner

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“…Particulate Matter (PM) is an intricate blend of solids and aerosols, comprising small droplets of liquid, fragments of dry solid, and solid cores coated with liquid. Based on size, PM is categorized mainly into PM 10 and PM 2.5 (diameter less than 2.5 µm) [2].…”

Section: Introduction and Background Knowledgementioning

confidence: 99%

Air Quality Monitoring Using Low-Cost Sensors in Urban Areas of Jodhpur, Rajasthan

Huda,

Kumar,

Gupta

et al. 2024

IJERPH

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Air pollution poses a significant health hazard in urban areas across the globe, with India being one of the most affected countries. This paper presents environmental monitoring study conducted in Jodhpur, Rajasthan, India, to assess air quality in diverse urban environments. The study involved continuous indoor and outdoor air quality monitoring, focusing on particulate matter (PM2.5) levels, bioaerosols, and associated meteorological parameters. Laser sensor-based low-cost air quality monitors were utilized to monitor air quality and Anderson 6-stage Cascade Impactor & Petri Dish methods for bioaerosol monitoring. The study revealed that PM2.5 levels were consistently high throughout the year, highlighting the severity of air pollution in the region. Notably, indoor PM2.5 levels were often higher than outdoor levels, challenging the common notion of staying indoors during peak pollution. The study explored the spatial and temporal diversity of air pollution across various land-use patterns within the city, emphasizing the need for tailored interventions in different urban areas. Additionally, bioaerosol assessments unveiled the presence of pathogenic organisms in indoor and outdoor environments, posing health risks to residents. These findings underscore the importance of addressing particulate matter and bioaerosols in air quality management strategies. Despite the study’s valuable insights, limitations, such as using low-cost air quality sensors and the need for long-term data collection, are acknowledged. Nevertheless, this research contributes to a better understanding of urban air quality dynamics and the importance of public awareness in mitigating the adverse effects of air pollution. In conclusion, this study underscores the urgent need for effective air quality management strategies in urban areas. The findings provide valuable insights for policymakers and researchers striving to address air pollution in rapidly urbanizing regions.

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“…These elements can induce immune responses that promote airway inflammation, hyperresponsiveness, and remodeling, laying the foundation for asthma’s clinical manifestations. [ 2 , 3 ]…”

Section: Introductionmentioning

confidence: 99%

Mediated Mendelian randomization analysis to determine the role of immune cells in regulating the effects of plasma metabolites on childhood asthma

Tan,

Yang,

Wang

et al. 2024

Medicine

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Childhood asthma is a chronic inflammatory disease of the airways, the pathogenesis of which involves multiple factors including genetic predisposition, environmental exposure, and immune system regulation. To date, the causal relationships between immune cells, plasma metabolites, and childhood asthma remain undetermined. Therefore, we aim to utilize the Mendelian randomization approach to assess the causal relationships among immune cells, plasma metabolites, and childhood asthma. This study employed the Mendelian randomization approach to investigate how immune cells influenced the risk of childhood asthma by modulating the levels of plasma metabolites. Five Mendelian randomization methods—inverse variance weighted, weighted median, Mendelian randomization-Egger, simple mode, and weighted mode—were utilized to explore the causal relationships among 731 types of immune cells, 1400 plasma metabolites, and childhood asthma. The instrumental variables for the 731 immune cells and 1400 plasma metabolites were derived from a genome-wide association study meta-analysis. Additionally, sensitivity analyses were conducted to examine the robustness of the results, potential heterogeneity, and pleiotropy. The inverse variance weighted results indicated that HLA DR on dendritic cells (DC) is a risk factor for childhood asthma (OR: 1.08, 95% CI: 1.02–1.14). In contrast, HLA DR on DC acts as a protective factor against elevated catechol glucuronide levels (OR: 0.94, 95% CI: 0.91–0.98), while catechol glucuronide levels themselves serve as a protective factor for childhood asthma (OR: 0.73, 95% CI: 0.60–0.89). Thus, HLA DR on DC can exert a detrimental effect on childhood asthma through the negative regulation of catechol glucuronide levels. The mediating effect was 0.018, accounting for a mediation effect proportion of 23.4%. This study found that HLA DR on DC can exert a risk effect on childhood asthma through the negative regulation of catechol glucuronide levels, providing new strategies for the prevention and treatment of childhood asthma and guiding future research and clinical practice.

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Environmental influences on childhood asthma: Climate change

Cited by 10 publications

References 92 publications

Climate change and its impact on asthma

Climate change and its impact on asthma

Air Quality Monitoring Using Low-Cost Sensors in Urban Areas of Jodhpur, Rajasthan

Mediated Mendelian randomization analysis to determine the role of immune cells in regulating the effects of plasma metabolites on childhood asthma

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