Environmental Influence of Epigenetics

Zhou, Feng; Resendiz, Marisol; Lo, Chiao-Ling

doi:10.1016/b978-0-12-805388-1.00031-6

Cited by 4 publications

(3 citation statements)

References 122 publications

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“…Environmental influences (nutrition, exercise, stress, alcohol) can determine the degree of transient or persistent changes occurring as either DNA methylation or histone modifications (altering gene expression) (Zhou et al, 2017). Early work established a possible role for epigenetics in diabetes onset, where the effect of maternal and intrauterine malnutrition and growth retardation was postulated to develop T2DM.…”

Section: Epigenetics and T2dmmentioning

confidence: 99%

The metabolic-epigenetic nexus in type 2 diabetes mellitus

Davison

Irwin

Walsh

2021

Free Radical Biology and Medicine

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Section: Epigenetics and T2dmmentioning

confidence: 99%

The metabolic-epigenetic nexus in type 2 diabetes mellitus

Davison

Irwin

Walsh

2021

Free Radical Biology and Medicine

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“…Here, we propose to examine DNA methylation as one possible mechanism through which both direct and indirect genetic effects may act. Epigenetic mechanisms such as DNA methylation modulate gene expression [14], but are themselves subject to both genetic [15,16] and environmental influences [17]. Animal studies have shown that early life environmental exposures like diet, trauma, and social deprivation can induce epigenetic reprogramming in cells.…”

Section: Introductionmentioning

confidence: 99%

Intergenerational transmission of complex traits and the offspring methylome

Hagenbeek,

Pool,

Van Asselt

et al. 2024

Preprint

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The genetic makeup of parents can directly or indirectly affect their offspring phenome through genetic transmission or via the environment that is influenced by parental heritable traits. Our understanding of the mechanisms by which indirect genetic effects operate is limited. Here, we hypothesize that one mechanism is via the offspring methylome. To test this hypothesis polygenic scores (PGSs) for schizophrenia, smoking initiation, educational attainment (EA), social deprivation, body mass index (BMI), and height were analyzed in a cohort of 1,528 offspring and their parents (51.5% boys, mean [SD] age = 10 [2.8] years). We modelled parent and offspring PGSs on offspring DNA methylation, accounting for the own PGS of offspring, and found significant associations between parental PGSs for schizophrenia, EA, BMI, and height, and offspring methylation sites, comprising 16, 2, 1, and 6 sites, respectively (alpha = 2.7 × 10−5). More DNA methylation sites were associated with maternal than paternal PGSs, possibly reflecting the maternal pre- or periconceptional environment during critical embryonic development.

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“…The combinations of polymorphisms in the serotoninergic and catecholaminergic pathways [ 10 , 11 ] and environmental factors [ 12 ] might be mediated or affected by epigenetic changes. Epigenetics includes heritable changes in the gene function that cannot be explained by changes in the DNA sequence, influencing both gene expression and phenotype [ 13 , 14 ]. In particular, DNA methylation is an epigenetic mark involved in gene expression regulation, catalyzed by a family of DNA methyltransferases that transfer a methyl group from S-adenyl methionine onto the DNA cytosine to form 5-methylcytosine [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

DNA Methylation Changes in Fibromyalgia Suggest the Role of the Immune-Inflammatory Response and Central Sensitization

Gerra

Carnevali

Ossola

et al. 2021

JCM

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Fibromyalgia (FM) has been explained as a result of gene-environment interactions. The present study aims to verify DNA methylation differences in eleven candidate genome regions previously associated to FM, evaluating DNA methylation patterns as potential disease biomarkers. DNA methylation was analyzed through bisulfite sequencing, comparing 42 FM women and their 42 healthy sisters. The associations between the level of methylation in these regions were further explored through a network analysis. Lastly, a logistic regression model investigated the regions potentially associated with FM, when controlling for sociodemographic variables and depressive symptoms. The analysis highlighted significant differences in the GCSAML region methylation between patients and controls. Moreover, seventeen single CpGs, belonging to other genes, were significantly different, however, only one cytosine related to GCSAML survived the correction for multiple comparisons. The network structure of methylation sites was different for each group; GRM2 methylation represented a central node only for FM patients. Logistic regression revealed that depressive symptoms and DNA methylation in the GRM2 region were significantly associated with FM risk. Our study encourages better exploration of GCSAML and GRM2 functions and their possible role in FM affecting immune, inflammatory response, and central sensitization of pain.

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Environmental Influence of Epigenetics

Cited by 4 publications

References 122 publications

The metabolic-epigenetic nexus in type 2 diabetes mellitus

The metabolic-epigenetic nexus in type 2 diabetes mellitus

Intergenerational transmission of complex traits and the offspring methylome

DNA Methylation Changes in Fibromyalgia Suggest the Role of the Immune-Inflammatory Response and Central Sensitization

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