Environmental fate of the antiviral drug Tamiflu in two aquatic ecosystems

Saccà, Maria Ludovica; Accinelli, Cesare; Fick, Jerker; Lindberg, Richard H.; Olsén, Björn

doi:10.1016/j.chemosphere.2008.11.060

Cited by 55 publications

(38 citation statements)

References 29 publications

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“…Previous investigations indicate that a considerable amount of OC is not broken down during water treatment processes and is broken down slowly during natural processes, which can lead to the accumulation of OC in the environment (21)(22)(23)(24)(25)(26)(27)(28). Therefore, the demonstrated ability of OC in drinking water to select OCresistant influenza H5N2 virus variants is of concern considering that OC-resistant viruses are already increasing in frequency in human populations (7,(10)(11)(12), even in areas of low oseltamivir drug use (8).…”

Section: Discussionmentioning

confidence: 99%

“…Importantly, OC is poorly removed or degraded by natural environmental conditions or sewage treatment (21)(22)(23)(24)(25)(26)(27)(28), resulting in significant retention in waterways. These same waterways often support large numbers of waterfowl, the primary reservoir of avian influenza A viruses (AIVs), and waterfowl in several parts of the world are likely exposed over lengthy periods to at least low doses of OC in their drinking water.…”

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confidence: 99%

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Effect of Oseltamivir Carboxylate Consumption on Emergence of Drug-Resistant H5N2 Avian Influenza Virus in Mallard Ducks

Achenbach

Bowen

2013

Antimicrob Agents Chemother

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Oseltamivir carboxylate (OC) has been detected in environmental waters at various levels during recent influenza seasons in humans, reflecting levels of usage and stability of this drug. In consideration of the role of waterfowl as hosts for influenza viruses that may contribute to human infections, we evaluated the effect of consumption of low doses of OC on development of oseltamivir-resistant influenza virus mutants in mallard ducks (Anas platyrhynchos) infected with two different low-pathogenic (LP) H5N2 avian influenza viruses (AIV). We detected development of virus variants carrying a known molecular marker of oseltamivir resistance (neuraminidase E119V) in 4 out of 6 mallards infected with A/Mallard/Minnesota/182742/1998 (H5N2) and exposed to 1,000 ng/liter OC. The mutation first appeared as a minor population on days 5 to 6 and was the dominant genotype on days 6 to 8. Oseltamivir-resistant mutations were not detected in virus from ducks not exposed to the drug or in ducks infected with a second strain of virus and similarly exposed to OC. Virus isolates carrying the E119V mutation displayed in vitro replication kinetics similar to those of the wild-type virus, but in vivo, the E119V virus rapidly reverted back to wild type in the absence of OC, and only the wild-type parental strain was transmitted to contact ducks. These results indicate that consumption by wild waterfowl of OC in drinking water may promote selection of the E119V resistance mutation in some strains of H5N2 AIV that could contribute to viruses infecting human populations.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Effect of Oseltamivir Carboxylate Consumption on Emergence of Drug-Resistant H5N2 Avian Influenza Virus in Mallard Ducks

Achenbach

Bowen

2013

Antimicrob Agents Chemother

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“…However, when these products reach the environment, they produce undesirable effects on ecosystems (Khan 2004;Sacca et al 2009). Even if the sewage undergoes treatment in WWTPs, some micropollutants are quite difficult to remove (Melo et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Removal Capacity of Caffeine, Hormones, and Bisphenol by Aerobic and Anaerobic Sewage Treatment

Froehner

Piccioni

Machado

et al. 2010

Water Air Soil Pollut

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The number of chemical compounds in sewage and consequently their release into the environment is increasing. Some of them are toxic and many of them are considered endocrine disrupters. Here, the capacity of three wastewater treatment plants (WWTPs) to remove caffeine, hormones and bisphenol-A was investigated. Bisphenol-A and caffeine are highly water-soluble compounds, as opposed to hormones (estradiol, estriol, and ethynilestradiol) which are hydrophobic compounds. In the Sewage Treatment Plant (SWT)1 the sewage is treated by activated sludge process, in the second plant, SWT2, sewage is treated by upflow anaerobic sludge blanket reactors followed by dissolved air flotation, and in the third, SWT3 sewage is treated by stabilization lagoons. The first lagoon is 3.5 m deep, thus facultative and polishment processes occur. It was speculated that there was a difference in efficiency between the three plants in removing micropollutants. Small differences were found in the amounts removed, probably accounted for by retention time. The caffeine and bisphenol-A were almost completely removed, higher than 90% for both compounds (bisphenol-A and caffeine) in all WWTPs. The hormones, however, had a smaller rate of removal, between 70% and 87%. It is suspected that retention time is essential for removal efficiency, together with type of treatment. In fact, the hormones, caffeine, and bisphenol-A found in the environment definitely come from untreated sewage.

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“…Zidovudine, lamivudine, and nevirapine were detected in rivers in Kenya at μg L −1 level (Koreje et al, 2012). Biodegradation, photodegradation, and ozonation of oseltamivir and its carboxylates have been studied via bench-scale experiments as well as investigations in sewage treatment plants (Accinelli et al, 2007(Accinelli et al, , 2010aBartels and von Tumpling, 2008;Ghosh et al, 2010a,b;Goncalves et al, 2011;Mestankova et al, 2012;Sacca et al, 2009). Recently, Prasse et al (2011) revealed rapid biotransformation of acyclovir and penciclovir in activated sludge, whereas the transformation product of acyclovir, carboxy-acyclovir was found to be persistent and was detected in drinking water, groundwater, and surface water from 40 ng L −1 to 3.2 μg L −1 .…”

Section: Introductionmentioning

confidence: 99%

Profile and behavior of antiviral drugs in aquatic environments of the Pearl River Delta, China

Peng

Wang

Zhang

et al. 2014

Science of The Total Environment

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Environmental fate of the antiviral drug Tamiflu in two aquatic ecosystems

Cited by 55 publications

References 29 publications

Effect of Oseltamivir Carboxylate Consumption on Emergence of Drug-Resistant H5N2 Avian Influenza Virus in Mallard Ducks

Effect of Oseltamivir Carboxylate Consumption on Emergence of Drug-Resistant H5N2 Avian Influenza Virus in Mallard Ducks

Removal Capacity of Caffeine, Hormones, and Bisphenol by Aerobic and Anaerobic Sewage Treatment

Profile and behavior of antiviral drugs in aquatic environments of the Pearl River Delta, China

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