Environmental factors predicting nephritis in systemic lupus erythematosus.

McAlindon, T.E.; Giannotta, L; Taub, Nicholas; D’Cruz, David; Hughes, G. R. V.

doi:10.1136/ard.52.10.720

Cited by 38 publications

(26 citation statements)

References 17 publications

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“…We did not have information on tobacco use in our cohort, but other cohort studies of SLE patients reported current smoking prevalences similar to the general population [38][39][40][41][42], although one study reported heavier use of tobacco by smokers with SLE [38]. Another possible explanation for the observed increase in lung cancer in our cohort is that lung involvement and fibrosis in particular is common in SLE patients [9].…”

Section: Discussionmentioning

confidence: 63%

Cancer risk in a cohort of patients with systemic lupus erythematosus (SLE) in California

Parikh‐Patel

White

Allen

et al. 2008

Cancer Causes Control

124

153

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Objective-We conducted a retrospective cohort study to examine cancer risk in a large cohort of systemic lupus erythematosus (SLE) patients in California.Methods-The cohort consisted of individuals with SLE derived from statewide patient discharge data during the period 1991-2002. SLE patients were followed using cancer registry data to examine patterns of cancer development. Standardized incidence ratios (SlRs) and 95% CI were calculated to compare the observed to expected numbers of cancers based on age-, race-, and sex-specific incidence rates in the California population.Results-The 30,478 SLE patients were observed for 157,969 person-years. A total of 1,273 cancers occurred within the observation interval. Overall cancer risk was significantly elevated (SIR=1.14, 95% CI=1.07-1.20). SLE patients had higher risks of vagina/vulva (SIR=3.27, 95% CI=2.41-4.31) and liver cancers (SIR=2.70, 95% CI=1.54-4.24). Elevated risks of lung, kidney, and thyroid cancers and several hematopoietic malignancies were also observed. Individuals had significantly lower risks of several screenable cancers, including breast, cervix, and prostate.Conclusions-These data suggest that risks of several cancer types are elevated among SLE patients. Detailed studies of endogenous and exogenous factors that drive these associations are needed.The final publication is available at Sprinter via: http://dx

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Section: Discussionmentioning

confidence: 63%

Cancer risk in a cohort of patients with systemic lupus erythematosus (SLE) in California

Parikh‐Patel

White

Allen

et al. 2008

Cancer Causes Control

124

153

View full text Add to dashboard Cite

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“…SLE patients who are current smokers were also found to suffer from more episodes of pleuritis and peritonitis and to express more neuropsychiatric symptoms [71]. Lupus nephritis did not appear to be related to tobacco exposure [72], although smoking has been associated with accelerated development of end-stage renal failure [73].…”

Section: Smoking and Slementioning

confidence: 98%

Effects of tobacco smoke on immunity, inflammation and autoimmunity

Arnson

Shoenfeld

Amital

2010

Journal of Autoimmunity

790

591

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“…With the ability to understand and manage high-risk pregnancies, outcomes for both mother and fetus have significantly improved. While some women with SLE experience recurrent spontaneous abortions, excessive fetal wastage, and disease exacerbations during pregnancy, overall there is agreement that with proper therapeutic intervention and careful prenatal care, many women with SLE can conceive, maintain pregnancies, and deliver healthy babies (16,(19)(20)(21)(22)(23).…”

Section: Systemic Lupus Erythematosus and Pregnancymentioning

confidence: 99%

“…The renal transplant literature reports successful pregnancies maintained on prednisone, azathioprine, and/or cyclosporine (23,32,38,39). All three drugs have been used successfully during pregnancy for SLE patients with intact renal function (40)(41)(42).…”

Section: Maternal Factorsmentioning

confidence: 99%

Pregnancy Outcomes in Female Renal Recipients: A Comparison of Systemic Lupus Erythematosus With Other Diagnoses

McGrory¹,

McCloskey²,

DeHoratius

et al. 2003

American Journal of Transplantation

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This study compares pregnancy outcomes in systemic lupus erythematosus (SLE) patients post renal transplant with recipients with other primary diagnoses, utilizing data from the National Transplantation Pregnancy Registry, Philadelphia, PA. Recipients were referred from transplant centers nationwide. A retrospective analysis was performed using data from questionnaires, hospital records and telephone interviews. Outcomes of pregnancies post renal transplant secondary to lupus nephritis (SLE: n Ω 38; 60 pregnancies) were compared with the pregnancy outcomes of renal recipients with other diagnoses (non-SLE: n Ω 247; 374 pregnancies). Drug-treated hypertension during pregnancy was less common in the SLE group than in the non-SLE group (45.0% vs. 62.5%, p Ω 0.015). There were fewer cesarean sections in the SLE group (30.2 vs. 53.2%, p Ω 0.008). There was no primary or gestational diabetes in the SLE group. There were no other statistical differences in maternal conditions or pregnancy outcomes between the SLE and non-SLE groups, or in the incidence of post pregnancy graft loss. Female recipients transplanted for renal failure secondary to lupus nephritis can successfully maintain pregnancy. Outcomes are comparable to renal recipients with other diagnoses. Newborns in both groups were often premature and had low birthweight. Overall childhood health was reported to be good; there were no apparent predominant structural malformations among the children.

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Environmental factors predicting nephritis in systemic lupus erythematosus.

Cited by 38 publications

References 17 publications

Cancer risk in a cohort of patients with systemic lupus erythematosus (SLE) in California

Cancer risk in a cohort of patients with systemic lupus erythematosus (SLE) in California

Effects of tobacco smoke on immunity, inflammation and autoimmunity

Pregnancy Outcomes in Female Renal Recipients: A Comparison of Systemic Lupus Erythematosus With Other Diagnoses

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