Environmental factors in inflammatory bowel disease: A case-control study based on a Danish inception cohort

Hansen, Thorsten; Jess, Tine; Vind, Ida; Elkjær, Margarita; Nielsen, Malene Fey; Gamborg, Michael; Munkholm, Pia

doi:10.1016/j.crohns.2011.05.010

Cited by 137 publications

(164 citation statements)

References 42 publications

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“…The present study identified a significant probability of low fruit and high refined sugar intake to be associated with UC similar to other (including Asian) studies [9][10][11][12][13] . The possible mechanism of protection is by antioxidant vitamins and fibres contained in these foods.…”

Section: Discussionsupporting

confidence: 75%

Association of Dietary Factors With Ulcerative Colitis in India

Ray¹

2015

Journal of Gastroenterology and Hepatology Research

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AIM:Western studies associate high intake of fat, animal protein, refined sugars and low intake of fruits and green vegetables with causation of ulcerative colitis. Indian data on such association is scanty. METHODS: 50 consecutive patients of ulcerative colitis were compared to 50 age and sex matched normal controls with respect to their demographic and nutritional parameters (based on commonly consumed food items in the region) in this prospective case control study. Food groups enquired for were meat, fish, cereals, fruits, green leafy vegetables, fried foods, refined sugar and tea/coffee and their intake was estimated semiquantitatively by a questionairre. Univariate and multivariate analysis of the parameters was carried out to detect the association of any with ulcerative colitis at significance level p < 0.05. RESULTS: Low intake of fruits (odds ratio 0.28 for the lowest intake level) and high intake of refined sugar (odds ratio 1.78 for the highest intake level) were the only significant factors associated with occurrence of ulcerative colitis on both univariate and multivariate analysis. None of the patients were pure vegetarians. CONCLUSION: This initial study showed association of ulcerative colitis with similar food items in India as in the West despite vast difference in dietary practices.

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Section: Discussionsupporting

confidence: 75%

Association of Dietary Factors With Ulcerative Colitis in India

Ray¹

2015

Journal of Gastroenterology and Hepatology Research

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“…This finding stimulated the performance of numerous observational studies, which analyzed the relationship between measles infection or vaccination and the development of IBD. The studies, which in general were case-control or cohort, obtained heterogeneous results [78][79][80][81][82][83][84][85] . Some had limitations in data gathering and do not enable confirmation of an epidemiological relationship between measles virus and IBD.…”

Section: Measlesmentioning

confidence: 99%

Pathogenesis of Crohn’s disease: Bug or no bug

Bosca-Watts

Tosca

Antón

et al. 2015

WJGP

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“…The evidence for the importance of the early childhood period comes from several sources: studies of human migration from areas of low prevalence to high prevalence and vice versa indicate that in some populations IBD risk is associated with the area of birth, 41 implicating events in the perinatal or early childhood period in IBD pathogenesis. Many of the epidemiological associations with IBD link to early childhood, including breastfeeding, tonsillectomy, childhood vaccinations, childhood infections, 42 birth rank 43 and birth in hospital. 44 In conjunction, several of these factors have been shown to influence the gut microbiota, 45 and the acquisition of the gut microbiota in humans appears to occur predominantly over the first 2 y of life.…”

mentioning

confidence: 99%

The gut microbiota of siblings offers insights into microbial pathogenesis of inflammatory bowel disease

et al. 2017

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Siblings of patients with Crohn's disease (CD) have elevated risk of developing CD and display aspects of disease phenotype, including faecal dysbiosis. In our recent article we have used 16S rRNA gene targeted high-throughput sequencing to comprehensively characterize the mucosal microbiota in healthy siblings of CD patients, and determine the influence of genotypic and phenotypic factors on the gut microbiota (dysbiosis). We have demonstrated that the core microbiota of both patients with CD and healthy siblings is significantly less diverse than controls. Faecalibacterium prausnitzii contributed most to core metacommunity dissimilarity between both patients and controls and between siblings and controls. Phenotype/genotype markers of CD risk significantly influenced microbiota variation between and within groups, of which genotype had the largest effect. Individuals with elevated CD-risk display mucosal dysbiosis characterized by reduced diversity of core microbiota and lower abundance of F. prausnitzii. The presence of this dysbiosis in healthy people at-risk of CD implicates microbiological processes in CD pathogenesis.

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Environmental factors in inflammatory bowel disease: A case-control study based on a Danish inception cohort

Cited by 137 publications

References 42 publications

Association of Dietary Factors With Ulcerative Colitis in India

Association of Dietary Factors With Ulcerative Colitis in India

Pathogenesis of Crohn’s disease: Bug or no bug

The gut microbiota of siblings offers insights into microbial pathogenesis of inflammatory bowel disease

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