Environmental Factors at the Periconceptional Period and the Occurrence of Cleft Lip and Palate in a Midwest Brazil Population

Silvestre, Carla Meliso Rodrigues; Silva, Ageo M. C.; Silva, Renata C. Giroto Da; Bittencourt, Walkiria Shimoya; Borba, Alexandre Meireles; Fernandes, Vander; Silva, Cristhiane A.L da

doi:10.1097/jom.0000000000002689

Cited by 3 publications

(1 citation statement)

References 49 publications

(133 reference statements)

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“…Related studies have shown that lowincome families, pesticide exposure history, smoking during pregnancy, gestational diabetes, and heavy metal exposure history such as Pb(lead), Cd (cadmium), and Sr(strontium) are all high-risk risks of OFCs. The reasonable supplement of vitamin, potassium and calcium during pregnancy is a protective factor to reduce the occurrence of OFCs [45][46][47][48]. However, due to the limitation of the number of studies included in this paper and the difference in the quality of the literature, Hansen CA et al only adjusted the age of pregnancy and lacked the adjustment of many related confounding factors, which would lead to deviations in the results [26].…”

Section: Discussionmentioning

confidence: 99%

Association between gestational exposure and risk of orofacial Clefts: A systematic review and meta-analysis

Huang

Qiu

et al. 2023

Preprint

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Background: The occurrence of orofacial Clefts (OFCs) is a congenital disease caused by many factors. According to recent studies, air pollution has a strong correlation with the occurrence of OFCs. However, there are still some controversies about the current research results, and there is no relevant research to review the latest results in recent years. Objective: In this paper, the authors conducted a systematic review and meta-analysis to explore the correlation between ambient air pollution and the occurrence of neonatal OFCs deformity. Methods: We searched Pubmed, Web of science, and Embase databases from the establishment of the database to May 2023. We included observational studies on the relationship between prenatal exposure to fine particulate matter 2.5 (PM2.5), fine particulate matter 10 (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2), ozone (O3), carbon monoxide (CO) and the risk of cleft lip (CL), cleft palate (CP), cleft lip with or without palate (CL/P). the Newcastle-Ottawa quality assessment scale (NOS) was used to evaluate the quality of the literature. Funnel plot and Egger's regression were used to verify the publication bias. Random effect model or fixed effect model was used to estimate the combined relative risk (RR) and 95% confidence interval (95%CI). Results: A total of eleven studies were included in this study, including four cohort studies and seven case-control studies, including 22453 cases of OFCs. Ten studies had low risk of bias and only one study had high risk of bias. Three studies reported that PM2.5 was positively correlated with CL and CP, with a combined RR and 95%CI of 1.287(1.174,1.411) and 1.267 (1.105,1.454). Two studies reported a positive correlation between O3 and CL, with a combined RR and 95%CI of 1.132(1.047,1.225). Two studies reported a positive correlation between PM10 and CL, with a combined RR and 95%CI of 1.108 (1.017,1.206). No association was found between SO2, CO, NO2 exposure during pregnancy and the risk of OFCs. Conclusion: The results of this study showed that there was a significant statistical correlation between exposure to PM10, PM2.5, O3 and the risk of OFCs in the second month of pregnancy. Exposure assessment, research methods and mechanisms need to be further explored.

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Section: Discussionmentioning

confidence: 99%

Association between gestational exposure and risk of orofacial Clefts: A systematic review and meta-analysis

Huang

Qiu

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Association between gestational exposure and risk of orofacial clefts: a systematic review and meta-analysis

Huang,

Wu,

Qiu

et al. 2023

BMC Pregnancy Childbirth

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Background The occurrence of orofacial Clefts (OFCs) is a congenital disease caused by many factors. According to recent studies, air pollution has a strong correlation with the occurrence of OFCs. However, there are still some controversies about the current research results, and there is no relevant research to review the latest results in recent years. Objective In this paper, the authors conducted a systematic review and meta-analysis to explore the correlation between ambient air pollution and the occurrence of neonatal OFCs deformity. Methods We searched Pubmed, Web of science, and Embase databases from the establishment of the database to May 2023. We included observational studies on the relationship between prenatal exposure to fine particulate matter 2.5 (PM2.5), fine particulate matter 10 (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2), ozone (O3), carbon monoxide (CO) and the risk of cleft lip (CL), cleft palate (CP), cleft lip with or without palate (CL/P). the Newcastle-Ottawa quality assessment scale (NOS) was used to evaluate the quality of the literature. Funnel plot and Egger’s regression were used to verify the publication bias. Random effect model or fixed effect model was used to estimate the combined relative risk (RR) and 95% confidence interval (95%CI). Results A total of eleven studies were included in this study, including four cohort studies and seven case-control studies, including 22,453 cases of OFCs. Ten studies had low risk of bias and only one study had high risk of bias. Three studies reported that PM2.5 was positively correlated with CL and CP, with a combined RR and 95%CI of 1.287(1.174,1.411) and 1.267 (1.105,1.454). Two studies reported a positive correlation between O3 and CL, with a combined RR and 95%CI of 1.132(1.047,1.225). Two studies reported a positive correlation between PM10 and CL, with a combined RR and 95%CI of 1.108 (1.017,1.206). No association was found between SO2, CO, NO2 exposure during pregnancy and the risk of OFCs. Conclusion The results of this study showed that there was a significant statistical correlation between exposure to PM10, PM2.5, O3 and the risk of OFCs in the second month of pregnancy. Exposure assessment, research methods and mechanisms need to be further explored.

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Pesticide Exposures during Pregnancy and Health Outcomes in Latin America and the Caribbean: A Scoping Review of Human Observational Studies

Rohweder,

Salcedo Arteaga,

da Silva Gomes

et al. 2024

J Health Pollut

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Environmental Factors at the Periconceptional Period and the Occurrence of Cleft Lip and Palate in a Midwest Brazil Population

Cited by 3 publications

References 49 publications

Association between gestational exposure and risk of orofacial Clefts: A systematic review and meta-analysis

Association between gestational exposure and risk of orofacial Clefts: A systematic review and meta-analysis

Association between gestational exposure and risk of orofacial clefts: a systematic review and meta-analysis

Pesticide Exposures during Pregnancy and Health Outcomes in Latin America and the Caribbean: A Scoping Review of Human Observational Studies

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