Environmental factors associated with baseline and serial changes in fractional exhaled nitric oxide (FeNO) in spice mill workers

Walt, Anita van der; Baatjies, Roslynn; Singh, Tanusha; Jeebhay, Mohamed F.

doi:10.1136/oemed-2015-103005

Cited by 9 publications

(4 citation statements)

References 34 publications

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“…The triglyceride glucose (TyG) index, which is calculated from fasting measurements of triglyceride and glucose, has been suggested as a reliable surrogate marker of IR 6 – 8 . Previous studies have found that a high baseline TyG index was related to the development of diabetes and coronary atherosclerosis 9 – 11 .…”

Section: Introductionmentioning

confidence: 99%

Comparison of the triglyceride glucose index and blood leukocyte indices as predictors of metabolic syndrome in healthy Chinese population

Lin

Zhang

Liu

et al. 2021

Sci Rep

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Triglyceride glucose (TyG) index and inflammatory markers are reported to have a positive association with metabolic syndrome (MetS). However, no previous study has assessed the value of TyG index and inflammatory markers as predictors of metabolic syndrome in the same study. This study looks at the comparison of the triglyceride index and blood leukocyte indices as predictors of metabolic syndrome in the Chinese population. The study cohort involved 1542 Chinese population without metabolic syndrome. The subjects underwent comprehensive routine health examination in 2011 and returned for a follow-up examination in 2016. Metabolic syndrome was defined according to Chinese Diabetes Society criteria, using body mass index for the replacement of waist circumference. TyG index, total leukocytes, neutrophils, lymphocytes, and neutrophil-to-lymphocyte ratio (NLR) were measured. Adjust d logistic models were used to assess the relationship between TyG index, blood leukocyte indices, and incident MetS. Receiver operating characteristic (ROC) curves were performed to determine the predictive value of TyG index and blood leukocyte indices for MetS. Results from multivariate logistic regression analysis showed that, in the adjusted model, the subjects with the highest quartile of TyG index and neutrophils had a 3.894- and 1.663-fold increased incidence of MetS (P < 0.0001 and P = 0.027), respectively. No significant association was observed between total leukocytes, lymphocytes, NLR with incident MetS. ROC analysis showed that the AUC of TyG index and neutrophils were 0.674 and 0.568 for incident MetS, respectively. TyG index rather than blood leukocyte indices may have the strongest predictive value in MetS development over a 5-year period.

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Section: Introductionmentioning

confidence: 99%

Comparison of the triglyceride glucose index and blood leukocyte indices as predictors of metabolic syndrome in healthy Chinese population

Lin

Zhang

Liu

et al. 2021

Sci Rep

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“…FeNO tends to increase 24 h after exposure to the allergen and measurement of FeNO is recognized as an accurate, reproducible, and important non-invasive surrogate marker for airway inflammation. There was almost 12% increase within 24 h thus demonstrating a strong association with elevated levels of suspended spice dust [24]. Similarly, in a study conducted in Grenada, occupational exposure and respiratory health problems among nutmeg production workers were observed in Grenada.…”

Section: Exposure Assessmentmentioning

confidence: 88%

Assessment of Occupational Health Hazards Due to Particulate Matter Originated from Spices

Upadhyay

Al-Mass

Dasgupta

et al. 2019

IJERPH

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Spices have been known for their various health activities; however, they also possess the allergic potential for the respiratory system and the skin as they are fine particulate matter. Persons involved in spice agriculture and food industries are at greater risk since they are exposed to a considerable amount of combustible dust, which may be the cause of fire and explosion and adversely affect the health. These workers may experience allergy, long-term and short-term respiratory issues including occupational asthma, dermatitis, etc. Some spices induce T cell-based inflammatory reaction upon contact recognition of the antigen. Antigen Presenting Cells (APC) on binding to the causative metabolite results in activation of macrophages by allergen cytokine interleukin (IL)-12 and tumor necrosis factor-beta (TNF). Cross-reactivity for protein allergens is another factor which seems to be a significant trigger for the stimulation of allergic reactions. Thus, it was imperative to perform a systematic review along with bioinformatics based representation of some evident allergens has been done to identify the overall conservation of epitopes. In the present manuscript, we have covered a multifold approach, i.e., to categorize the spice particles based on a clear understanding about nature, origin, mechanisms; to assess metabolic reactions of the particles after exposure as well as knowledge on the conditions of exposure along with associated potential health effects. Another aim of this study is to provide some suggestions to prevent and to control the exposure up to some extent.

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“…The ATS/ERS guidelines make evidence based recommendations in the interpretation of FeNO levels and they have been used in African studies (52,53). Elevated FeNO levels greater than 50ppb in adults and greater than 35ppb in children indicate eosinophilic airway in ammation that is suggestive of probable allergic asthma.…”

Section: Lung Function Assessmentmentioning

confidence: 99%

A Feasibility Study to Assess Imbrasia Belina (Mopane Worm) Sensitisation and Related Respiratory Health Outcomes in a Rural Community in Gwanda District, Zimbabwe

Ndlovu

Chimbari

Sibanda³

et al. 2020

Preprint

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Background: Allergic diseases are considered to be some of the fastest growing chronic conditions in Africa. Of concern is the paucity of knowledge about the local environment and its role in allergic disease development. In response to this, we explored whether Imbrasia belina, a popular indigenous edible insect commonly known as mopane worm, is a potential allergen of clinical and public health significance in Zimbabwe. This study was intended to assess the plausibility and feasibility of this hypothesis with a view to evaluate the insect’s health impact in a larger study.Methods: The study participants included both male and female villagers aged 10 years and above in Gwanda district, Zimbabwe. Eligible participants who completed the household questionnaire were referred to the local clinic for skin prick tests and to measure lung function and allergic airway inflammation. Allergen sensitization patterns were evaluated using 10 different inhalant allergen extracts including an in-house preparation of mopane worm. Lung function was measured with a Koko Legend spirometer and fractional exhaled nitric oxide levels (FeNO) (NIOX VERO) were measured in participants with at least one abnormal spirometric parameter. Data was analysed using Stata version 13 software.Results: Of the 46 eligible participants that completed the household questionnaire, 17 went to the clinic giving a response rate of 37%. Majority who completed the questionnaire were adults (91%) and the children (9%) were all female. The prevalence of sensitization to Imbrasia belina was 50% and the prevalence ranged from 22% to 72% for the other allergens including cockroach, mosquito and house dust mites. The data collection tools were safe and well tolerated by participants with no adverse events reported. Self-reported respiratory symptoms, abnormal lung function and elevated FeNO were recorded amongst participants sensitised to mopane worm.Conclusion: Pre-defined feasibility criteria were met with the exception of a lower than expected response rate for clinic data collection in this pilot study. For the main study, an increase in the sample size and more consistent community engagement will be applied to improve the response rates.

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Environmental factors associated with baseline and serial changes in fractional exhaled nitric oxide (FeNO) in spice mill workers

Cited by 9 publications

References 34 publications

Comparison of the triglyceride glucose index and blood leukocyte indices as predictors of metabolic syndrome in healthy Chinese population

Comparison of the triglyceride glucose index and blood leukocyte indices as predictors of metabolic syndrome in healthy Chinese population

Assessment of Occupational Health Hazards Due to Particulate Matter Originated from Spices

A Feasibility Study to Assess Imbrasia Belina (Mopane Worm) Sensitisation and Related Respiratory Health Outcomes in a Rural Community in Gwanda District, Zimbabwe

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