Environmental factors as modulators of neurodegeneration: Insights from gene–environment interactions in Huntington's disease

Mo, Christina; Hannan, Anthony J.; Renoir, Thibault

doi:10.1016/j.neubiorev.2015.03.003

Cited by 90 publications

(52 citation statements)

References 237 publications

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“…30,31 High levels of physical activity are associated with delayed symptom progression in individuals with the Huntington disease gene. 32 A similar delay in onset of Parkinson disease symptoms has been found. 33 …”

Section: Preventionsupporting

confidence: 67%

Stepping Up to Rethink the Future of Rehabilitation: IV STEP Considerations and Inspirations

Kimberley

Novak

Boyd

et al. 2017

Pediatric Physical Therapy

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Background and Purpose The IV STEP conference challenged presenters and participants to consider the state of science in rehabilitation, highlighting key area of progress since the previous STEP conference related to prediction, prevention, plasticity, and participation in rehabilitation. Key Points Emerging from the thought-provoking discussions was recognition of the progress we have made as a profession and a call for future growth. In this summary article, we present a recap of the key points and call for action. We review the information presented and the field at large as it relates to the 4 Ps: prediction, prevention, plasticity, and participation. Recommendations for Practice Given that personalized medicine is an increasingly important approach that was clearly woven throughout the IV STEP presentations, we took the liberty of adding a fifth “P,” Personalized, in our discussion of the future direction of the profession.

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Section: Preventionsupporting

confidence: 67%

Stepping Up to Rethink the Future of Rehabilitation: IV STEP Considerations and Inspirations

Kimberley

Novak

Boyd

et al. 2017

Pediatric Physical Therapy

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“…A review of the preclinical and clinical studies suggest that even though HD is a highly penetrant, single-gene disorder, an individual's environmental influences may significantly affect disease onset and progression [34]. Diagnosis of HD is based on clinical presentation of motor abnormalities.…”

Section: Environmental Factors and Hd Disease Symptomsmentioning

confidence: 99%

“…Studies in mouse models have provided more detailed effects of stress on disease phenotypes. Mo and colleagues provide an excellent review on this topic [34]. Such detailed clinical studies on stress have not yet been done in HD families, but should be guided by these important animal findings.…”

Section: Environmental Factors and Hd Disease Symptomsmentioning

confidence: 99%

DNA methylation in Huntington’s disease: Implications for transgenerational effects

Thomas

2016

Neuroscience Letters

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Huntington’s disease (HD) is a devastating, neurodegenerative disorder caused by a CAG repeat mutation in the HTT gene. A growing body of evidence suggests that epigenetic modifications play a key role in HD pathogenesis. Expression of the disease protein, huntingtin, leads to extensive transcriptional dysregulation due to disruption of histone-modifying complexes and altered interactions with chromatin-related factors. Such epigenetic mechanisms also readily respond to environmental factors, which are now thought to influence the risk, onset and progression of neurodegenerative disorders, including HD. DNA methylation is an epigenetic modification that has been studied intensively, however, its role in HD is just emerging. In this review, DNA methylation differences associated with HD will be summarized, as well as the role of environmental factors to alter DNA methylation in a manner that could alter disease phenotypes. Further, transgenerational epigenetic inheritance will be discussed in the context of relevant environmental factors and their potential links to HD. The study of epigenetic states in HD presents an opportunity to gain new insights into risk factors and pathogenic mechanisms associated with HD, as well as to inform about treatment options.

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“…Common pathological molecular mechanisms contributing to HD include reactive oxygen species (ROS), mitochondrial dysfunction and neuroinflammation. 1 Exposure to the Mediterranean Diet (MD) provides neuroprotection and has anti-oxidant and anti-inflammatory properties. [2][3][4] Adherence to the MD could positively influence age of onset and progression of HD.…”

Section: Identification Of Pathways Involved In Hdmentioning

confidence: 99%

A46 Neurodegenerative markers in hd: association with clinical charactersitcs, triplet expansion, phenoconversion and mediterranean diet adherence

Christodoulou

Sokratous

Spyrou

et al. 2018

Pathogenic Mechanisms

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Environmental factors as modulators of neurodegeneration: Insights from gene–environment interactions in Huntington's disease

Cited by 90 publications

References 237 publications

Stepping Up to Rethink the Future of Rehabilitation: IV STEP Considerations and Inspirations

Stepping Up to Rethink the Future of Rehabilitation: IV STEP Considerations and Inspirations

DNA methylation in Huntington’s disease: Implications for transgenerational effects

A46 Neurodegenerative markers in hd: association with clinical charactersitcs, triplet expansion, phenoconversion and mediterranean diet adherence

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