Environmental Factors and Protective Effects of Epigallocatechin-3-Gallate to Systemic Lupus Eritematosus: A Review Study

Abstract

SLE (Systemic Lupus Erythematosus) is one of autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage in the affected organs. Etiology and pathogenesis are not clearly mention until now by the scientist, but environmental factor is contribute to development of Lupus and Flare disease. The objective of this study to explain the relationship between environmental factors and pathogenesis development of SLE, and how the Epigallocatechin-3-Gallate (EGCG) can protect or prevent of organs damage and environmental effects. Method:The research design of this study was used literature review. The data sources collected from Electronic database in Pubmed, Sage, Google Scholar and website of science including reports, journals and mostly published in the last 10 years. Results:The pathomechanism of SLE was influenced by environmental factors and this was caused an increasing of oxidative stress, chronic inflammation, dysregulation of immune system and decreased the clean of immune complex and apoptosis of cells. The production of autoantibodies and immune complex are related with target tissue with is it was caused chronic inflammation and the end it caused irreversible damage in glomerulus of the kidneys, arteries, lungs and other tissues. EGCG plays a protecting role in environmental factors as a trigger because it works as an antioxidant, anti-inflammatory and immunomudulator. So EGCG can as a potential agent to protect SLE. Conclusion:Environmental factors plays an important role as a triger of SLE and flare. Moreover, EGCG as a potential agent to protect the presence of oxidative stress, inflammation and immune dysregulation.