Environmental factor(s) during suckling exert long-term effects upon blood pressure and body weight in spontaneously hypertensive and normotensive rats

Azar, Silvia; Kabat, Vivian; Bingham, C. Raymond

doi:10.1097/00004872-199104000-00003

Cited by 41 publications

(47 citation statements)

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“…Maternal environments play a role in altering the growth rate, BP and subsequent pathophysiology [1,3,42,43]. Recent studies reported that salt intake showed a linear relationship to SBP, while extreme salt restriction caused an increased risk for all-cause mortality [44] with "J" shaped relationships in cardiovascular events [4,45,46].…”

Section: Discussionmentioning

confidence: 99%

“…All other dietary components were similar in all study groups. For this study, special diets were made by Tekled Premier (Madison, WI), based on the American Institute of Nutrition Rodent Diets [3,22].…”

Section: Methodsmentioning

confidence: 99%

“…Genetic and environmental factors play an important role in disease expression on offspring by exerting diverse and predominant modulatory effects [1][2][3]. Cardiac disease and chronic kidney disease (CKD) commonly coexist, sharing cardiovascular disease (CVD) risk factors such as hypertension, dyslipidemia and diabetes.…”

Section: Introductionmentioning

confidence: 99%

“…Perinatal dietary imbalance may induce structural changes in a progeny's body that can lead to injury, especially given genetic susceptibility [1,3]. Some authors have addressed epigenetic effects -in the relationship between longevity and food availability in the transgeneration response to swings in nutrition -on the regulation of reproduction with disease risk [7].…”

Section: Introductionmentioning

confidence: 99%

“…The altered maturation patterns of glomerular and/or tubular mass can trigger adaptive mechanisms that lead to glomerular hypertension later in life [10]. Maternal stress and nutritional conditions modulated BP and renal injuries at all stages, altered glomerular filtration and resulted in glomerulosclerosis [2,3,11,12]. Excessive salt intake can be hypertensinogenic in susceptible individuals, adversely affecting target organsespecially among the aging population, as renal function declines [11].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Perinatal Protein-Nacl Diets on Offspring's Blood Pressure and Renal Function in Lewis Rats

Lee¹,

Azar²

2013

TOHYPERJ

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Perinatal diets may affect the cardiovascular-renal functions of offspring. To understand effects of maternal diet on the renal function and blood pressure (BP) of offspring, protein (10% low, LP; 23% normal, NP) and/or NaCl (4% high salt, HS; 0.6% normal, NS) diets were started at pre-pregnancy through pups' weaning to either a 4% high NaCl (hs) or 0.6% NaCl (ns) diet. Telemetered BP data was analyzed by methods of linear least square rhythmometry. Systolic BPs (circadian mean ±SE mm Hg) were: NPNSns, 131±2; NPNShs, 137±2; NPHSns, 137±0.2; NPHShs, 134±3; LPNSns, 138±1; LPNShs, 138±0.6; LPHSns, 135±2; LPHShs, 142±2. Offspring in NPNShs and NPHSns had significantly increased SBPs versus NPNSns (both P<0.05). Most LP-offspring had increased SBP (P<0.01 to <0.05) and lower body weight (BW) with smaller glomerular filtration rate changes (renal reserve, RR-GFR) following overnight acute highprotein loads: RR-GFRs (inulin, ml/min/g kidney) for groups stated above were, respectively: 0.935; 0.927; 0.537; -0.064; -0.229; 0.057; -0.515; -0.404. The kidney weight/BW ratio of offspring was higher on hs-than on ns-diets (all P<0.001). Rats on a low caloric diet had reduced sclerotic glomerular numbers compared to those on normal diets (11.2±1 vs. 15.7±2, P<0.001), though glomerular numbers were similar in both groups.In summary, perinatal LP-HS diets significantly affected the BW, BP, renal injuries and kidney function of offspring. RR was seriously reduced, especially among offspring in hs-and perinatal LP groups. The most interesting result was the glomerular maturation staging in the pups, which suggests delayed nephrogenesis by a maternal LP diet.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of Perinatal Protein-Nacl Diets on Offspring's Blood Pressure and Renal Function in Lewis Rats

Lee¹,

Azar²

2013

TOHYPERJ

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Blood pressure responses to feeding in infancy: Spin‐offs of serendipity

Myers

Shair

Cohen

2005

Developmental Psychobiology

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This article summarizes results from a program of research that has focused on understanding the characteristics of, and factors that shape, acute cardiovascular responses to feeding in infants. The work developed from behavioral observations in rats suggesting a linkage between variations in maternal behavior and adult blood pressure. However, the hypothesis that specific types of interactions, in particular those associated with feeding, might alter cardiovascular function was greatly influenced by a serendipitous observation made by Myron Hofer several years earlier. Myron discovered that nutrient availability is a key regulator of cardiovascular function in newborn rats. Our spin-off studies established that, in newborn rats and human infants, ingestion of nutrient is associated with robust increases in heart rate and blood pressure.

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Milk electrolyte content of Dahl hypertensive and normotensive rats

McCarty

Tong

1995

Physiology & Behavior

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Environmental factor(s) during suckling exert long-term effects upon blood pressure and body weight in spontaneously hypertensive and normotensive rats

Cited by 41 publications

References 0 publications

Effects of Perinatal Protein-Nacl Diets on Offspring's Blood Pressure and Renal Function in Lewis Rats

Effects of Perinatal Protein-Nacl Diets on Offspring's Blood Pressure and Renal Function in Lewis Rats

Blood pressure responses to feeding in infancy: Spin‐offs of serendipity

Milk electrolyte content of Dahl hypertensive and normotensive rats

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