Environmental exposures and mechanisms in allergy and asthma development

Murrison, Liza Bronner; Brandt, Eric B.; Myers, Jocelyn Biagini; Hershey, Gurjit K. Khurana

doi:10.1172/jci124612

Cited by 246 publications

(176 citation statements)

References 190 publications

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“…An increasing prevalence of allergic diseases, such as atopic dermatitis, allergic rhinitis, and asthma, as well as food allergies, has been noted in western societies (1,2). Increasing incidences have also been reported in newly developed Asian countries, such as Taiwan (3,4).…”

Section: Introductionmentioning

confidence: 99%

Goat Milk Consumption Enhances Innate and Adaptive Immunities and Alleviates Allergen-Induced Airway Inflammation in Offspring Mice

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Goat Milk Consumption Enhances Innate and Adaptive Immunities and Alleviates Allergen-Induced Airway Inflammation in Offspring Mice

et al. 2020

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“…Following the initial “hygiene hypothesis,” many epidemiological studies provided direct evidence for the correlation between the prevalence of asthma and living environmental condition in children and explored the underlying immunological and molecular mechanisms. 33 34 35 36 In 1999, Braun-Fahrländer et al . 37 first found that the risk of atopic constitution and allergies in children who grew up on farms was significantly lower than those who grew up in non-farm conditions.…”

Section: Environmental and Microbial Exposurementioning

confidence: 99%

Important Role of Immunological Responses to Environmental Exposure in the Development of Allergic Asthma

Lin

Ren

Xiao

et al. 2020

Allergy Asthma Immunol Res

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Allergic asthma is a public health problem that affects human health and socioeconomic development. Studies have found that the prevalence of asthma has significantly increased in recent years, which has become particularly pronounced in developed countries. With rapid urbanization in China in the last 3 decades, the prevalence of asthma has increased significantly in urban areas. As changes in genetic backgrounds of human populations are limited, environmental exposure may be a major factor that is responsible for the increased prevalence of asthma. This review focuses on environmental components of farms and rural areas that may have protective effects in reducing the development of asthma. Farm and rural related microorganism- and pathogen-associated molecular patterns are considered to be important environmental factors that modulate host's innate and adaptive immune system to induce protection effects later in life. Environmental microbial-related immunotherapy will also be discussed as the future research direction for the prevention of allergic asthma.

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“…Environmental exposures, especially in early life, play an important role in the development of asthma. Some environmental exposures, such as air pollution, cigarette smoking, and early life respiratory viral infections are risk factors for the development of asthma, whereas others have protective effects, including exposure to pets, prolonged breast feeding, and a higher diversity of the microbiome in early life [12,[53][54][55][56][57]. Besides, some in utero exposures such as maternal nutrition, maternal disease (e.g.…”

Section: Environmental Epigenetics In Asthma Developmentmentioning

confidence: 99%

The role of epigenetics in the development of childhood asthma

Koppelman

2019

Expert Review of Clinical Immunology

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Introduction: The development of childhood asthma is caused by a combination of genetic factors and environmental exposures. Epigenetics describes mechanisms of (heritable) regulation of gene expression that occur without changes in DNA sequence. Epigenetics is strongly related to aging, is cell-type specific, and includes DNA methylation, noncoding RNAs, and histone modifications. Areas covered: This review summarizes recent epigenetic studies of childhood asthma in humans, which mostly involve studies of DNA methylation published in the recent five years. Environmental exposures, in particular cigarette smoking, have significant impact on epigenetic changes, but few of these epigenetic signals are also associated with asthma. Several asthma-associated genetic variants relate to DNA methylation. Epigenetic signals can be better understood by studying their correlation with gene expression, which revealed higher presence and activation of blood eosinophils in asthma. Strong associations of nasal methylation signatures and atopic asthma were identified, which were replicable across different populations. Expert commentary: Epigenetic markers have been strongly associated with asthma, and might serve as biomarker of asthma. The causal and longitudinal relationships between epigenetics and disease, and between environmental exposures and epigenetic changes need to be further investigated. Efforts should be made to understand cell-type-specific epigenetic mechanisms in asthma.

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Environmental exposures and mechanisms in allergy and asthma development

Cited by 246 publications

References 190 publications

Goat Milk Consumption Enhances Innate and Adaptive Immunities and Alleviates Allergen-Induced Airway Inflammation in Offspring Mice

Goat Milk Consumption Enhances Innate and Adaptive Immunities and Alleviates Allergen-Induced Airway Inflammation in Offspring Mice

Important Role of Immunological Responses to Environmental Exposure in the Development of Allergic Asthma

The role of epigenetics in the development of childhood asthma

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