Environmental exposure to organochlorine pesticides and deficits in cochlear status in children

Sisto, Renata; Moleti, Arturo; Murínová, Ľubica Palkovičová; Wimmerová, Soňa; Lancz, Kinga; Tihányi, Juraj; Čonka, Kamil; Šovčíková, Eva; Hertz‐Picciotto, Irva; Jusko, Todd A.; Trnovec, T.

doi:10.1007/s11356-015-4690-5

Cited by 20 publications

(18 citation statements)

References 57 publications

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“…[22] Considering how a nutritional deficiency, such as limited iron stores, might affect relations between pesticide exposure and infant auditory function is another novel aspect of this pilot study.…”

Section: Discussionmentioning

confidence: 99%

“…However, a recent study of environmental exposure to organochlorine pesticides in children found evidence of deficits in cochlear status. [22]…”

Section: Discussionmentioning

confidence: 99%

“…One recent study found deficits in cochlear status in children exposed to organochlorine pesticides. [22] Regarding visual sensory function, a recent study in an Arctic population with high DDE exposure found that both pre- and postnatal DDE exposure were associated with visual processing impairment at school age. [23]…”

Section: Introductionmentioning

confidence: 99%

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Prenatal exposure to multiple pesticides is associated with auditory brainstem response at 9months in a cohort study of Chinese infants

Sturza

Silver

et al. 2016

Environment International

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Background Pesticides are associated with poorer neurodevelopmental outcomes, but little is known about the effects on sensory functioning. Methods Auditory brainstem response (ABR) and pesticide data were available for 27 healthy, full-term 9-month-old infants participating in a larger study of early iron deficiency and neurodevelopment. Cord blood was analyzed by gas chromatography-mass spectrometry for levels of 20 common pesticides. The ABR forward-masking condition consisted of a click stimulus (masker) delivered via ear canal transducers followed by an identical stimulus delayed by 8, 16, or 64 milliseconds (ms). ABR peak latencies were evaluated as a function of masker-stimulus time interval. Shorter wave latencies reflect faster neural conduction, more mature auditory pathways, and greater degree of myelination. Linear regression models were used to evaluate associations between total number of pesticides detected and ABR outcomes. We considered an additive or synergistic effect of poor iron status by stratifying our analysis by newborn ferritin (based on median split). Results Infants in the sample were highly exposed to pesticides; a mean of 4.1 pesticides were detected (range 0-9). ABR Wave V latency and central conduction time (CCT) were associated with the number of pesticides detected in cord blood for the 64ms and non-masker conditions. A similar pattern seen for CCT from the 8ms and 16ms conditions, although statistical significance was not reached. Increased pesticide exposure was associated with longer latency. The relation between number of pesticides detected in cord blood and CCT depended on the infant’s cord blood ferritin level. Specifically, the relation was present in the lower cord blood ferritin group but not the higher cord blood ferritin group. Conclusions ABR processing was slower in infants with greater prenatal pesticide exposure, indicating impaired neuromaturation. Infants with lower cord blood ferritin appeared to be more sensitive to the effects of prenatal pesticide exposure on ABR latency delay, suggesting an additive or multiplicative effect.

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Section: Discussionmentioning

confidence: 99%

“…However, a recent study of environmental exposure to organochlorine pesticides in children found evidence of deficits in cochlear status. [22]…”

Section: Discussionmentioning

confidence: 99%

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Prenatal exposure to multiple pesticides is associated with auditory brainstem response at 9months in a cohort study of Chinese infants

Sturza

Silver

et al. 2016

Environment International

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“…DPOAEs were recorded as described previously (Jusko et al, 2014; Sisto et al, 2015) by the Echoport ILO 292 USB-I Otodynamics Ltd. (Hatfield, Herts, UK) instrument connected to a personal computer equipped with ILO V6 software. In these measurements, a miniaturized OAE probe, housing two loudspeakers and a sensitive microphone, is inserted in the ear canal.…”

Section: Methodsmentioning

confidence: 99%

PCB exposure and cochlear function at age 6 years

Murínová

Moleti

Sisto

et al. 2016

Environmental Research

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Epidemiological studies have documented adverse associations between exposure to polychlorinated biphenyls (PCBs) and otological outcomes. Previously, we documented decreased distortion product otoacoustic emission (DPOAE) levels in children exposed to PCBs, up to the age of 45 months, amongst a cohort of children in eastern Slovakia. The objective of the present study is to evaluate cochlear dysfunction at 72 months of age in 214 children from this same cohort and to compare the otoacoustic test sensitivity to that of pure tone audiometry (PTA). The association between DPOAE, PTA, and PCBs was estimated by means of multivariate ANOVA (MANOVA) and linear regression models. ROC curves were computed to estimate the DPOAE-test power in children. The DPOAE level at 72 months was related to PCB-153 serum levels. The DPOAE Input/Output function test at mid-frequency (2 kHz) has shown instead nonmonotonic dependence on PCB exposure, for the left ears of children, over the whole growth curve. No significant association was found between PTA hearing levels and PCB-153 concentration. High diagnostic power of the DPOAE-test was found in children, similar to that found by the same authors in adults. In conclusions the DPOAE-PCB correlation obtained at 72 months is similar to that at 45 months suggesting a permanent and stable ototoxic effect of the PCB exposure. The lack of statistical significance of the PCB-PTA correlation suggests that DPOAEs are sensitive biomarkers of cochlear damage.

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“…The papers published in this special issue demonstrate that low levels of pesticides can significantly alter concentrations of hormones in children and influence sexual maturation (Croes et al 2014); result in a developmental disorder (Sisto et al 2015) induce liver diseases (Carvalho et al 2014); and cancer (Porta 2014). Another study shows the influence of Dioxin on sperm quality (Galimova et al 2014).…”

mentioning

confidence: 99%