“…1,2 Moreover, co-infection with both HIV-1 and HIV-2 occurs in some countries of West Africa where the viruses co-circulate. 3,4 Sexual transmission is responsible for the majority of HIV-2 infections due to infected semen or cervicovaginal secretions containing infected lymphocytes. 5 Ideally, a vaginal/rectal microbicide should have the following features: to be acceptable and affordable, offer maximal and immediate protection, remain in the vagina for a few hours to act against the sexual transmitted diseases (STDs) during and after sexual intercourse, not leak immediately after application, not accumulate to avoid toxicity effects, not affect the normal vaginal flora, and be compatible with male latex condom.…”