Environmental exposure to arsenic and chromium in children is associated with kidney injury molecule-1

Cárdenas-González, M.; Osorio-Yáñez, Citlalli; Gaspar-Ramírez, Octavio; Pavkovic, Mira; Ochoa-Martínez,; López-Ventura, D.; Medeiros, Mara; Barbier, Olivier; Pérez-Maldonado, Iván N.; Sabbisetti, Venkata; Bonventre, Joseph V.; Vaidya, Vishal S.

doi:10.1016/j.toxlet.2016.07.375

Cited by 4 publications

(3 citation statements)

References 35 publications

(40 reference statements)

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“…Arsenic exposure as a risk factor for renal disease has been recognized as early as 1970 (Levy, Lewin, Ninin, Schneider, & Milne, ; Robles‐Osorio, Sabath‐Silva, & Sabath, ; Uldall, Khan, Ennis, McCallum, & Grimson, ; Zheng et al, ). However, the use of biomarkers such as KIM‐1 (Kidney Injury Molecule‐1) in studies on arsenic‐mediated nephrotoxicity is recent (Cárdenas‐González et al, ).…”

Section: Discussionmentioning

confidence: 99%

Chronic arsenic intoxication diagnostic score (CAsIDS)

Dani

Walter

2017

J of Applied Toxicology

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Arsenic and its compounds are well-established, potent, environmentally widespread and persistent toxicants with metabolic, genotoxic, mutagenic, teratogenic, epigenetic and carcinogenic effects. Arsenic occurs naturally in the Earth's crust, but anthropogenic arsenic emissions have surmounted the emissions from important natural sources such as volcanism. Inorganic arsenicals exhibit acute and chronic toxicities in virtually all cell types and tissues, and hence arsenic intoxication affects multiple systems. Whereas acute arsenic intoxication is rare and relatively easy to diagnose, chronic arsenic intoxication (CAsI) is common but goes often misdiagnosed.Based on a review of the literature as well as our own clinical experience, we propose a chronic arsenic intoxication diagnostic score (CAsIDS). A distinctive feature of CAsIDS is the use of bone arsenic load as an essential criterion for the individual risk assessment of chronic arsenic intoxication, combined with a systemic clinical assessment. We present clinical examples where CAsIDS is applied for the diagnosis of CAsI, review the main topics of the toxicity of arsenic in different cell and organ systems and discuss the therapy and prevention of disease caused or aggravated by chronic arsenic intoxication. CAsIDS can help physicians establish the diagnosis of CAsI and associated conditions.

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Section: Discussionmentioning

confidence: 99%

Chronic arsenic intoxication diagnostic score (CAsIDS)

Dani

Walter

2017

J of Applied Toxicology

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“…It is even harder to identify those exposed who have some biochemical or physiological response (biomarker detectable-a biomarker is a molecule, gene, or characteristic by which a particular pathological or physiological process or disease is identifiable), since a suitable marker needs to be known and readily detectable, preferably without invasive techniques such as taking a blood, e.g., other less invasive bio-monitoring sampling methods such as hair, nail, urine, saliva for biomarker determination [73,74]. In environmental situations, an estimate of the larger numbers potentially …”

Section: Receptors: Measurement Of Disease and Riskmentioning

confidence: 99%

“…determination [73,74]. In environmental situations, an estimate of the larger numbers potentially exposed (at risk) may be possible.…”

Section: Receptors: Measurement Of Disease and Riskmentioning

confidence: 99%

Environment and Human Health: The Challenge of Uncertainty in Risk Assessment

Stewart

Hursthouse

2018

Geosciences

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High quality and accurate environmental investigations and analysis are essential to any assessment of contamination and to the decision-making process thereafter. Remediation decisions may be focused by health outcomes, whether already present or a predicted risk. The variability inherent in environmental media and analysis can be quantified statistically; uncertainty in models can be reduced by additional research; deep uncertainty exists when environmental or biomedical processes are not understood, or agreed upon, or remain uncharacterized. Deep uncertainty is common where health and environment interact. Determinants of health operate from the individual's genes to the international level; often several levels act synergistically. We show this in detail for lead (Pb). Pathways, exposure, dose and response also vary, modifying certainty. Multi-disciplinary approaches, built on high-quality environmental investigations, enable the management of complex and uncertain situations. High quality, accurate environmental investigations into pollution issues remain the cornerstone of understanding attributable health outcomes and developing appropriate responses and remediation. However, they are not sufficient on their own, needing careful integration with the wider contexts and stakeholder agendas, without which any response to the environmental assessment may very well founder. Such approaches may benefit more people than any other strategy.

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Health Impacts of Cr Contamination in Soil

Astuti,

Rauf

2023

Chromium in Plants and Environment

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Environmental exposure to arsenic and chromium in children is associated with kidney injury molecule-1

Cited by 4 publications

References 35 publications

Chronic arsenic intoxication diagnostic score (CAsIDS)

Chronic arsenic intoxication diagnostic score (CAsIDS)

Environment and Human Health: The Challenge of Uncertainty in Risk Assessment

Health Impacts of Cr Contamination in Soil

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