Environmental Exposure and Bladder Cancer in Young Males2

Benton, Barbara; Henderson, Brian E.

doi:10.1093/jnci/51.1.269

Cited by 28 publications

(11 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] The number of cases per family was two (n=15), three (n=15), six (n=1), and one family with 5 TCCUT and one squamous cell bladder cancer. When tumor site was specified, eleven families had bladder TCC only, nine included TCC of the bladder and renal pelvis/ureter, and one presented only ureteral cancer.…”

Section: Case Reports Of Familial Tccutmentioning

confidence: 99%

“…[2] Furthermore, a genetic predisposition to bladder cancer is suggested by the occurrence of TCCUT in several Mendelian disorders [8][9][10][11], epidemiologic studies showing that a positive TCCUT family history increases bladder cancer risk [12][13][14][15][16][17][18][19][20][21][22][23][24], and a limited number of case reports describing multiple-case TCCUT families. [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] Therefore, both genetic and environmental factors play a role in the development of bladder and related urinary tract cancers. Here we update a previously-reported family, report a new multiple-case kindred, critically review the familial TCCUT literature, and provide a brief summary of genetic factors that have been implicated in TCCUT risk.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Familial and genetic risk of transitional cell carcinoma of the urinary tract

Mueller¹,

Caporaso²,

Greene³

2008

Urologic Oncology: Seminars and Original Investigations

View full text Add to dashboard Cite

Environmental exposures, including tobacco smoke and occupational exposure to aromatic amines, have been implicated in bladder cancer etiology. However, the pathogenesis of urinary bladder transitional cell carcinoma remains incompletely defined. In epidemiologic studies, family history confers a two-fold increase in bladder cancer risk, but it is uncertain whether this represents evidence of a genetic and/or a shared environmental basis for familial aggregation. Polymorphisms in genes involved in the metabolism of environmental toxins (e.g., NAT2) clearly modify individual susceptibility to bladder cancer. A genetic predisposition has also been suggested by case reports describing multiple-case families, and the development of bladder cancer in association with several well-described Mendelian disorders (e.g., HNPCC, retinoblastoma). Here we update a previouslyreported family, report a new multiple-case kindred, critically review previously-reported bladder cancer families and the epidemiologic literature related to family history of transitional cell carcinoma of the urinary tract (TCCUT) as a risk factor, as well as provide a brief summary of genetic factors that have been implicated in TCCUT risk. We conclude that familial TCCUT is either very uncommon or significantly under-reported, perhaps on the assumption that this is an environmental rather than a genetic disorder. The interaction between multiple genetic and environmental factors has made it challenging to identify genetic components responsible for many common diseases; therefore, a proposed genome-wide association study (GWAS) for urinary bladder cancer may help to clarify the etiologic role of the candidate genetic pathways reviewed here, as well as characterize gene/environment interactions that contribute to TCCUT carcinogenesis.

show abstract

Section: Case Reports Of Familial Tccutmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Familial and genetic risk of transitional cell carcinoma of the urinary tract

Mueller¹,

Caporaso²,

Greene³

2008

Urologic Oncology: Seminars and Original Investigations

View full text Add to dashboard Cite

show abstract

“…1 Although most pediatric tumours may be considered congenital, this is controversial. Shukla's review expresses concern about an increasing incidence, potentially secondary to environmental toxins, 4 while other reports have included common adult carcinogens, such as schistosomiasis, industrial exposure 10,11 and radiation. 12 Smoking is felt to be much less of a factor in patients <20 years old.…”

Section: Discussionmentioning

confidence: 99%

Mimickers and tumours in the lower urinary tract: Need for a more efficient vigilance?

Metcalfe

Bascom

Sergi

2013

CUAJ

View full text Add to dashboard Cite

Lower urinary tract symptoms are common in pediatric urology, but an atypical presentation may portend significant pathophysiology. We present 5 cases of young males with a sudden change in urinary symptoms, which resulted in the discovery of a variety of benign bladder tumours. We present the clinical, radiologic and histologic findings of these cases emphasizing on mimickers in clinics. Although rare tumours, these may be increasing in frequency and pediatric care may further be enhanced by the development of multinational registry.

show abstract

“…Benton and Henderson presented a 19-year-old patient with bladder cancer whose father was diagnosed with bladder cancer 1 year before. Although the son was occupationally exposed to glues and solvents and the father was a welder, the early ages at diagnosis argue against a pure exogenous cause [3]. A striking family was reported by McCullough et al in six members of a two-generation family.…”

Section: Anecdotal Evidence For An Inherited Subtypementioning

confidence: 97%

Hereditary bladder cancer

Kiemeney

2008

Scandinavian Journal of Urology and Nephrology

View full text Add to dashboard Cite

First degree relatives of patients with bladder cancer have a two-fold increased risk of bladder cancer but high-risk bladder cancer families are extremely rare. There is no clear Mendelian inheritance pattern that can explain the increased familial risk. This makes classical linkage studies for the mapping of susceptibility genes impossible. The disease is probably caused by a combination of exposure to exogenous carcinogens and a large number of susceptibility genes with modest effects. Genome-wide association studies are better suited to identify these genes. Three such studies are currently underway and are expected to report their results in 2008.

show abstract

Environmental Exposure and Bladder Cancer in Young Males2

Cited by 28 publications

References 0 publications

Familial and genetic risk of transitional cell carcinoma of the urinary tract

Familial and genetic risk of transitional cell carcinoma of the urinary tract

Mimickers and tumours in the lower urinary tract: Need for a more efficient vigilance?

Hereditary bladder cancer

Contact Info

Product

Resources

About