Environmental Epigenetics and Effects on Male Fertility

Guerrero-Bosagna, Carlos; Skinner, Michael K.

doi:10.1007/978-1-4614-7783-9_5

Cited by 23 publications

(19 citation statements)

References 141 publications

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“…There is now considerable evidence in laboratory animals and in humans exposed to environmental toxicants that an increase in the incidence of cryptorchidism is observed (see reviews by Guerrero‐Bosagne & Skinner, ; Barthold et al ., and Foster et al ., ). One study using the rat showed a transgenerational affect when rats were exposed to di(2‐ethylhexyl) phthalate (DHEP; Chen et al ., ).…”

Section: ‘If We Fail To Connect We Have a Problem’mentioning

confidence: 99%

We, the developing rete testis, efferent ducts, and Wolffian duct, all hereby agree that we need to connect

Santos

Hinton

2019

Andrology

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Background:The mechanisms by which the rete testis joins the efferent ducts, which joins the Wolffian duct during development, are not known. Mouse and chick models have been helpful in identifying genes that are important for the development of each part, but genes have not been identified as to those that play a role in the joining of each part. Clinical implications of the failure of the male reproductive tract to form a fully functional conduit for spermatozoa are not trivial. Epididymal disjunction, the failure of the efferent ducts to join the testis, is one of several epididymal anomalies that have been observed in some boys who were cryptorchid at birth. Objective: A systematic review of studies focusing on the morphogenesis of the mesonephric duct and mesonephric tubules in different species, and identification of clinical issues should there be failure of these tissues to develop. Design: PubMed and GUDMAP databases, and review of books on kidney development were searched for studies reporting on the mechanisms of morphogenesis of the kidney and epididymis. Main outcomes measure(s): Gaps in our knowledge were identified, and hypotheses coupled with suggestions for future experiments were presented. Results: A total of 64 papers were identified as relevant, of which 53 were original research articles and 11 were book chapters and reviews covering morphogenesis and clinical issues. Investigators utilized multiple species including, human, mouse, chick, Xenopus, bovine, and sheep. Conclusion: Fundamental understanding of the morphogenesis of the male reproductive tract is limited, especially the morphogenesis of the rete testis and efferent ducts. Therefore, it is not surprising that we do not understand how each part unites to form a whole. Only one mechanism of joining of one part of the tract to another was identified: the joining of the Wolffian duct to the cloaca via controlled apoptosis.

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Section: ‘If We Fail To Connect We Have a Problem’mentioning

confidence: 99%

We, the developing rete testis, efferent ducts, and Wolffian duct, all hereby agree that we need to connect

Santos

Hinton

2019

Andrology

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“…Epigenetics is the study of mitotically and/or meiotically heritable modifications regulating genome activity without any impact on DNA sequences. Proper regulation of epigenetic processes including DNA methylation, histone modifications and nuclear protein transitions, and noncoding RNAs during gonadal development and spermatogenesis is crucial for the maintenance of embryonic development and normal sperm function (Guerrero‐Bosagna & Skinner, ; Gunes & Kulac, ; Rajender, Avery, & Agarwal, ). Fertilisation status and sperm function may be affected by changes during the epigenetic process.…”

Section: Cigarette Smoking and Epigenetic Alterationsmentioning

confidence: 99%

“…Sperm cells are known to have a unique epigenetic programming (Boissonnas, Jouannet, & Jammes, ), and epigenomic components of the sperm cell have been proposed to be adversely affected by cigarette smoke, resulting in offspring with developmental defects (Esakky & Moley, ) (Figure ). Somatic cells of the testis involved in the regulation of spermatogenesis undergo epigenetic modifications as well (Guerrero‐Bosagna & Skinner, ).…”

Section: Cigarette Smoking and Epigenetic Alterationsmentioning

confidence: 99%

Smoking-induced genetic and epigenetic alterations in infertile men

et al. 2018

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Male fertility rates have shown a progressive decrease in both developing and industrialised countries in the past 50 years. Clinical and epidemiological studies have demonstrated controversial results about the harmful effects of cigarette smoking on seminal parameters. Some studies could not establish a negative effect by tobacco smoking on sperm quality and function, whereas others have found a significant reduction in sperm quality and function. This study reviews the components in cigarette smoke and discusses the effects of smoking on male fertility by focusing extensively on smoking-induced genetic and epigenetic alterations in infertile men. Chromosomal aneuploidies, sperm DNA fragmentation and gene mutations are discussed in the first section, while changes in DNA methylation, chromatin remodelling and noncoding RNAs are discussed in the second section as part of epigenetic alterations.

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“…Thus, the time taken from donating semen until its usage in assisted reproductive technology (ART) procedures is critical for their success. The quality of the male genetic material, which depends, among other things, on the degree of fragmentation of nuclear DNA, will have a direct impact on the embryo development and the health of future generations (Borini et al ., ; Dada et al ., ; Guerrero‐Bosagna & Skinner, ).…”

Section: Introductionmentioning

confidence: 99%

Decreased activity of superoxide dismutase in the seminal plasma of infertile men correlates with increased sperm deoxyribonucleic acid fragmentation during the first hours after sperm donation

Wdowiak

Bakalczuk²,

Bakalczuk

2015

Andrology

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Sperm DNA fragmentation varies between individuals and is more pronounced with increased patient age and time after sperm donation. The intensification of DNA fragmentation depends on the balance of the oxidoreductive system, which is regulated mainly by two enzymes - superoxide dismutase (SOD) and catalase. The objective of this study was to determine the relationship between sperm DNA fragmentation dynamics, fertility and seminal SOD and catalase activity. The study was conducted in 2013 and 2014 at the Non-Public Health Care Unit 'Ovum Reproduction and Andrology' in Lublin, Lublin, Poland, and covered 218 men aged 25-35 (85 fertile and 133 patients treated for infertility). Percentage of fragmented DNA was measured in a modified chromatin dispersion test at four time points after sperm donation (t = 0, 3, 6, 12 h). SOD and catalase activities were determined spectrophotometrically. We confirmed that the activity of SOD in the seminal plasma of men with reproductive disorders was lower compared with fertile men. Conversely, no significant correlations were found between fertility and catalase activity. Sperm DNA of infertile males was initially more fragmented than fertile male sperm DNA. SOD and catalase activity did not correlate with the degree of DNA fragmentation in fertile men. In men with reproductive disorders, the rate of DNA fragmentation was slow within first 3 h after sperm donation and then increased between 6 and 12 h. In this group of infertile men, those with higher SOD activity had a lower DNA fragmentation index (DFI) after 12 h, and a reduced rate of intensity of fragmentation from 6 to 12 h. Alternatively, higher catalase activity among men treated for infertility was accompanied by higher initial DFI and higher rate of DNA fragmentation from 6 to 12 h. These results highlight the importance of determining a proper time window between sperm donation and procedures of assisted reproductive technology.

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Environmental Epigenetics and Effects on Male Fertility

Cited by 23 publications

References 141 publications

We, the developing rete testis, efferent ducts, and Wolffian duct, all hereby agree that we need to connect

We, the developing rete testis, efferent ducts, and Wolffian duct, all hereby agree that we need to connect

Smoking-induced genetic and epigenetic alterations in infertile men

Decreased activity of superoxide dismutase in the seminal plasma of infertile men correlates with increased sperm deoxyribonucleic acid fragmentation during the first hours after sperm donation

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