Environmental epidemiology and neurological manifestations of dengue serotypes with special inference on molecular trends, virus detection, and pathogenicity

Anoopkumar, A. N.; Aneesh, Embalil Mathachan

doi:10.1007/s10668-020-01161-7

Cited by 6 publications

(3 citation statements)

References 93 publications

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“…To prevent transmission, reduce mosquito populations, use insect repellent and protective clothing, and implement surveillance and public health interventions. Vaccination is crucial to prevent virus transmission (Anoopkumar et al 2021).…”

Section: Transmission Of Dengue Fevermentioning

confidence: 99%

Vaccine Strategies for Dengue Fever

2023

IJAB

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Dengue fever, a widespread viral illness transmitted by mosquitoes, is a major global health concern, especially in tropical and subtropical areas. To proactively address the disease, vaccination plans have been created to minimize its effects. Significantly, the live attenuated vaccine Dengvaxia (CYD-TDV) has been recognized as an innovative intervention. This quadrivalent vaccine introduces individuals to less potent strains of all four dengue virus types, triggering an immune reaction without inducing the illness. The main objective of these vaccines is to provide protection against all virus strains at the same time. However, due to the complicated nature of dengue and its antibody-dependent enhancement, caution is needed in the development of vaccines to prevent making the disease worse. Efforts to implement vaccinations against dengue focus on areas with high rates of transmission, customizing the approach to target specific age groups or populations at higher risk of the disease's effects. Current research is working to improve current vaccines and create new ones to address challenges in vaccine effectiveness and adaptability to different geographic and demographic conditions. The changing nature of dengue transmission and the specific factors related to different age groups highlight the need for flexible vaccine strategies. Consistent communication and advancements in science from health authorities are helping to reduce the global impact of dengue fever through successful vaccination programs.

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Section: Transmission Of Dengue Fevermentioning

confidence: 99%

Vaccine Strategies for Dengue Fever

2023

IJAB

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“…The four serotypes of dengue are responsible for an extensive spectrum of clinical signs and symptoms, from mild febrile illness to severe and fatal diseases like dengue shock syndrome (DSS) and dengue haemorrhagic fever (DHF). [4][5][6] There are various challenges in creating effective medications against dengue fever, despite the large number of recent research efforts. Due to the fact that DENV exhibits antibody-dependent enhancement (ADE), which allows pre-existing antibodies to attach to DENV and increase the risk of dengue infection.…”

Section: Introductionmentioning

confidence: 99%

Exploring the inhibitory potential of Nigella sativa against dengue virus NS2B/NS3 protease and NS5 polymerase using computational approaches

2023

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“…Dengue Fever is a mosquito-borne viral infection causing serious flu-likened diseases that often lead to a life-threatening condition known as dengue shock syndrome (DSS) ( Liu et al, 2021 ). Inapparent Flavivirus ( Flaviviridae ) genus dengue virus (DENV) infections lead to a wide range of clinical involvement ranging from mild febrile disease to severe DSS (Dengue Hem) ( Anoopkumar and Aneesh, 2021 ). Dengue in humans is transmitted by Aedes aegypti and Aedes albopictus mosquitoes ( Weiskopf and Sette, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Epidemiological screening and serotyping analysis of dengue fever in the Southwestern region of Saudi Arabia

Alshabi

Marwan

Fatima

et al. 2022

Saudi Journal of Biological Sciences

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Dengue is an acute systemic viral disease that has been developed globally in both chronic and epidemic transmission periods. Dengue virus (DENV) is a member of the Flavivirus genus of the Flaviviridae family, which endangers public health. Limited studies have been performed in the Saudi Arabia and there are no epidemiological as well as molecular screening of DENV in the Southwestern region and this current study was conducted on the epidemiology of dengue in the Southwestern region of Saudi Arabia. Simultaneously, we have screened the 100 patients for DENV using the real-time reverse transcriptase polymerase chain reaction (RT-PCR) assay. The current study results confirmed that 6637 people from various hospitals and locations in Jazan, Southwestern regions, were enrolled in this study from 2012 to 2020. The overall mean age was 30.02 ± 18.01 years, with 62.8% of males and 37.2% of females enrolled. This study included nearly three-fourths of the Saudi participants and one-fourth of the expatriates, and 56.6% of the positive cases were enrolled. In 2019, the most instances were enrolled, with 44% of positive cases. When screened using the RT-PCR assay, 93% of the positive patients were recruited, according to the quality control analysis. In conclusion, the current study results confirmed the prevalence of DENV was increased drastically since 2012 to 2020. High number of cases were registered prior to the Pandemic. The screening for DENV was performed with RT-PCR assay and NSI antigen should also be implemented to cross-check the results which was previously performed with RT-PCR analysis.

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Environmental epidemiology and neurological manifestations of dengue serotypes with special inference on molecular trends, virus detection, and pathogenicity

Cited by 6 publications

References 93 publications

Vaccine Strategies for Dengue Fever

Vaccine Strategies for Dengue Fever

Exploring the inhibitory potential of Nigella sativa against dengue virus NS2B/NS3 protease and NS5 polymerase using computational approaches

Epidemiological screening and serotyping analysis of dengue fever in the Southwestern region of Saudi Arabia

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