Environmental Enrichment Improved Learning and Memory, Increased Telencephalic Cell Proliferation, and Induced Differential Gene Expression in Colossoma macropomum

Pereira, Patrick Douglas Corrêa; Henrique, Ediely Pereira; Porfírio, Danillo Monteiro; Crispim, Caio César de Sousa; Campos, Maitê Thaís Barros; Oliveira, Renata Melo de; Silva, Isabella Mesquita Sfair; Guerreiro, Luma Cristina Ferreira; Silva, Tiago Werley Pires da; Silva, Anderson de Jesus Falcão da; Rosa, João Batista da Silva; Azevedo, Dmitre Leonardo Ferreira de; Lima, Cecília Gabriella Coutinho; Abreu, Cintya Castro de; Filho, Carlos Santos; Diniz, Domingos Luiz Wanderley Picanço; Magalhães, Nara Gyzely de Morais; Guerreiro-Diniz, Cristovam; Diniz, Cristovam Wanderley Picanço; Diniz, Daniel Guerreiro

doi:10.3389/fphar.2020.00840

Cited by 11 publications

(4 citation statements)

References 87 publications

(89 reference statements)

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“…Similarly, age and sex of fish can impact performance – again sticklebacks provide clear examples whereby males and females exhibit differences in cognitive performance (Keagy et al, 2019 ). Finally, fish that have been housed with levels of environmental complexity or predator regimes can exhibit differences in cognitive performance (DePasquale et al, 2021 ; Odling‐Smee & Braithwaite, 2003b ; Pereira et al, 2020 ; Salvanes et al, 2013 ; Spence et al, 2011 ), and behavioural responses such as measures of behavioural lateralization (Sundin et al, 2023 ). Broad generalizations from the results of this study should be made with care, as the authors studied animals from a single population in each experiment.…”

Section: Discussionmentioning

confidence: 99%

Maze design: size and number of choices impact fish performance in cognitive assays

Jones,

Cortese,

Munson

et al. 2023

Journal of Fish Biology

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Although studies on fish cognition are increasing, consideration of how methodological details influence the ability to detect and measure performance is lagging. Here, in two separate experiments the authors compared latency to leave the start position, latency to make a decision, levels of participation and success rates (whether fish entered the rewarded chamber as first choice) across different physical designs. Experiments compared fish performance across (a) two sizes of T‐mazes, large and standard, and a plus‐maze, and (b) open choice arenas with either two or four doors. Fish in T‐mazes with longer arms took longer to leave the start chamber and were less likely to participate in a trial than fish in T‐mazes with shorter arms. The number of options, or complexity, in a maze significantly impacted success but did not necessarily impact behavioural measures, and did not impact the number of fish that reached a chamber. Fish in the plus‐maze had similar latencies to leave the start box and time to reach any chamber as fish in the same‐sized T‐maze but exhibited lower overall success. Similarly, in an open choice arena, increasing the number of options – doors to potential reward chambers − resulted in lower probability of success. There was an influence of reward position in the choice arena, with rewarded chambers closest to the sides of the arena resulting in lower latencies to enter and higher probability of decision success. Together the results allow the authors to offer practical suggestions towards optimal maze design for studies of fish cognition.

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Section: Discussionmentioning

confidence: 99%

Maze design: size and number of choices impact fish performance in cognitive assays

Jones,

Cortese,

Munson

et al. 2023

Journal of Fish Biology

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“…Recently, an increasing amount of evidence has hinted that EE can improve memory and delay age-related cognitive dysfunctions [ 205 , 206 ]. Early exposure of EE to AD transgenic rodents was previously found to delay the onset of memory deficits as well as improve neuropathological hallmarks [ 207 , 208 , 209 ].…”

Section: Behavioral Effects Of Ee and Its Potential Application In Hu...mentioning

confidence: 99%

The Molecular Effects of Environmental Enrichment on Alzheimer’s Disease

2022

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Environmental enrichment (EE) is an environmental paradigm encompassing sensory, cognitive, and physical stimulation at a heightened level. Previous studies have reported the beneficial effects of EE in the brain, particularly in the hippocampus. EE improves cognitive function as well as ameliorates depressive and anxiety-like behaviors, making it a potentially effective neuroprotective strategy against neurodegenerative diseases such as Alzheimer’s disease (AD). Here, we summarize the current evidence for EE as a neuroprotective strategy as well as the potential molecular pathways that can explain the effects of EE from a biochemical perspective using animal models. The effectiveness of EE in enhancing brain activity against neurodegeneration is explored with a view to differences present in early and late life EE exposure, with its potential application in human being discussed. We discuss EE as one of the non pharmacological approaches in preventing or delaying the onset of AD for future research.

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“…Nonetheless, little is known about the genes expressed in distinct areas of encephalon in Tambaqui. A report by 10 analyzed the transcriptome of telencephalon of Tambaqui raised under distinct conditions of physical activity, revealing that specimens exposed to exercises were characterized by an increased number of positively regulated genes related to memory and learning as well as faster growth. However, this transcriptome was obtained from juvenile specimens while data about adult and sexually mature fish remain unpublished.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, the captive specimens are exposed to stressful environments distinct from those found in wild. Even after replicating natural conditions such as water currents, the natural breeding of Tambaqui has not been accomplished in captivity and positive regulation of genes related to stress stimuli has been reported 10 . Therefore, taking into account the importance of Tambaqui in aquaculture and the reliability of next generation molecular data in analyses of functional genomics, the present study provided useful information for further research by generating the first functional annotation of differentially expressed genes in the Neurotranscriptoma of adult males and females of C. macropomum .…”

Section: Introductionmentioning

confidence: 99%

First neurotranscriptome of adults Tambaquis (Colossoma macropomum) with characterization and differential expression between males and females

Miranda,

Veneza,

Ferreira

et al. 2024

Sci Rep

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The Tambaqui is one of the most representative Amazon fish species, being highly exploited in fisheries, aquaculture and as a research model. Nonetheless, data about functional genome are still required to evaluate reproductive and nutrition parameters as well as resistance to pathogens. The of next-generation sequencing has allows assessing the transcriptional processes in non-model species by providing comprehensive gene collections to be used as a database in further genomic applications and increased performance of captive populations. In this study, we relied on RNAseq approach to generate the first transcriptome of the telencephalon from adult males and females of Colossoma macropomum, resulting in a reference dataset for future functional studies. We retrieved 896,238 transcripts, including the identification of 267,785 contigs and 203,790 genes. From this total, 91 transcripts were differentially expressed, being 63 and 28 of them positively regulated for females and males, respectively. The functional annotation resulted in a library of 40 candidate genes for females and 20 for males. The functional enrichment classes comprised reproductive processes (GO:0,048,609; GO:0,003,006; GO:0,044,703; GO:0,032,504; GO:0,019,953) being related to sex differentiation (e.g., SAFB) and immune response (e.g., SLC2A6, AHNAK, NLRC3, NLRP3 and IgC MHC I alpha3), thus indicating that the genes in the neurotranscriptome of Tambaqui participate in sex differentiation and homeostasis of captive specimens. These data are useful to design the selection of genes related to sex determination and animal welfare in raising systems of Tambaqui.

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Environmental Enrichment Improved Learning and Memory, Increased Telencephalic Cell Proliferation, and Induced Differential Gene Expression in Colossoma macropomum

Cited by 11 publications

References 87 publications

Maze design: size and number of choices impact fish performance in cognitive assays

Maze design: size and number of choices impact fish performance in cognitive assays

The Molecular Effects of Environmental Enrichment on Alzheimer’s Disease

First neurotranscriptome of adults Tambaquis (Colossoma macropomum) with characterization and differential expression between males and females

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