Environmental enrichment decreases intravenous self-administration of amphetamine in female and male rats

Bardo, Michael T.; Klebaur, Jennifer E.; Valone, Joanne M.; Deaton, Christopher M.

doi:10.1007/s002130100720

Cited by 242 publications

(139 citation statements)

References 44 publications

Supporting

Mentioning

122

Contrasting

Order By: Relevance

“…Initially, there were significant housing differences during the 30-min habituation to the locomotor cages with higher activity in the HAn- SE relative to HAn-EE rats. These results are not in agreement with that of others, demonstrating no differences in activity levels between animals showing high (HAB) and low anxiety-like behavior (LAB) [19]. The findings are consistent with the reported differences in activity in the EPM for the HAn animals in the current study.…”

Section: Discussioncontrasting

confidence: 54%

“…Postnatal environments that are enriched (e.g., toys, wheels) can influence an animal’s coping skills [16] as well as its vulnerability to drugs of abuse such as cocaine [17], morphine [18] and amphetamine [19, 20]. Conflicting findings exist on enriched environment’s (EE) impact on stress with some reporting no difference in corticosterone levels at baseline or after stressor [21] and others indicating a reduction in Sprague-Dawley rats [22] or even elevated levels in enriched Wistar rats [23].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Environmental enrichment effects on the neurobehavioral profile of selective outbred trait anxiety rats

Ravenelle

Byrnes

et al. 2013

Behavioural Brain Research

View full text Add to dashboard Cite

Environmental enrichment attenuates the response to psychostimulants and has been shown to reduce both anxiety and stress-related behaviors. Since stress is a major vulnerability factor for addiction, we investigated whether enrichment could reverse stress profiles in high anxious rats as well as reduce their amphetamine sensitivity. Using selectively-bred high and low anxiety males (filial 3) from enriched, social or isolated environments, we tested elevated plus maze exploration, novelty place preference and amphetamine (AMPH; 0.5 mg/kg, IP)-induced hyperactivity. We measured plasma corticosterone (CORT) response after forced novel object exposure, phosphorylation of the tropomyosin-related kinase B receptor (pTrkB) in the hippocampus and striatum, and dopamine (D2) receptor mRNA levels in the striatum and nucleus accumbens. Results indicate that high anxiety animals reared in social or enriched environments spent more time on open arms of the EPM while low anxiety animals raised in enriched environments spent more time on open arms when compared to either isolated or social groups. There were no group differences or interactions found for novelty place preference. Enriched environments decreased the response to AMPH and stress-induced CORT regardless of trait but selectively decreased pTrkB and increased D2 mRNA levels in high anxiety animals. The results suggest that selectively-bred trait anxiety rats show state anxiety that is influenced by rearing environments, and D2 protein levels and BDNF/TrkB signaling may differentially contribute to integrating these effects.

show abstract

Section: Discussioncontrasting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Environmental enrichment effects on the neurobehavioral profile of selective outbred trait anxiety rats

Ravenelle

Byrnes

et al. 2013

Behavioural Brain Research

View full text Add to dashboard Cite

show abstract

“…Although this is the only study to investigate the effects of pair bonding experience on the rewarding properties of drugs of abuse, previous studies have demonstrated that other social experiences/factors may also influence drug reward. For example, rats reared with multiple social cohorts self-administered less AMPH (Bardo et al, 2001) and cocaine (Schenk et al, 1987) over repeated sessions than rats reared alone. Similarly, rats reared in an enriched environment that contained novel objects and social cohorts self-administered less AMPH, extinguished self-administration behavior sooner, and required higher doses of AMPH to reinstate drug-seeking than did rats housed alone (Bardo et al, 2001; Green et al, 2002; Stairs et al, 2006; c.f., Schenk et al, 1988; Bardo et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

“…For example, rats reared with multiple social cohorts self-administered less AMPH (Bardo et al, 2001) and cocaine (Schenk et al, 1987) over repeated sessions than rats reared alone. Similarly, rats reared in an enriched environment that contained novel objects and social cohorts self-administered less AMPH, extinguished self-administration behavior sooner, and required higher doses of AMPH to reinstate drug-seeking than did rats housed alone (Bardo et al, 2001; Green et al, 2002; Stairs et al, 2006; c.f., Schenk et al, 1988; Bardo et al, 1995). Furthermore, female rats trained to lever-press for cocaine showed markedly fewer responses after becoming pregnant and following parturition (Hecht et al, 1999), suggesting that the reproductive process and neurobiological changes involved with maternal experience may decrease the reinforcing properties of cocaine.…”

Section: Discussionmentioning

confidence: 99%

Social Bonding Decreases the Rewarding Properties of Amphetamine through a Dopamine D1 Receptor-Mediated Mechanism

Liu¹,

Young²,

Curtis³

et al. 2011

J. Neurosci.

View full text Add to dashboard Cite

Although the protective effects of social bonds on drug use/abuse have been well documented, we know little about the underlying neural mechanisms. Using the prairie vole (Microtus ochrogaster)—a socially monogamous rodent that forms long-term pair bonds after mating—we demonstrate that amphetamine (AMPH) conditioning induced a conditioned place preference (CPP) in sexually naïve (SN), but not pair-bonded (PB), males. Although AMPH treatment induced a similar magnitude of DA release in the nucleus accumbens (NAcc) of SN and PB males, it had differential effects on NAcc D1 receptor (D1R) binding. Specifically, AMPH treatment increased D1R binding in SN, but decreased D1R binding in PB males. NAcc D1R, but not D2R, antagonism blocked AMPH-induced CPP in SN males and NAcc D1R activation prior to AMPH conditioning enabled AMPH-induced CPP in PB males. Together, our data demonstrate that pair bonding experience decreases the rewarding properties of AMPH through a D1R mediated mechanism.

show abstract

“…The walls of one side chamber were decorated by horizontal blackand-white stripes, whereas vertical black-and-white stripes were used for the other side chamber. Our CPP procedure was modelled after a previous study [24]. On day 1, each male's initial compartment preference was tested ( pre-test).…”

Section: (B) Testosterone Dosementioning

confidence: 99%

Pair bonding prevents reinforcing effects of testosterone in male California mice in an unfamiliar environment

Zhao

Marler

2014

Proc. R. Soc. B.

View full text Add to dashboard Cite

Testosterone (T) can be released by stimuli such as social interactions, and thereby influence future social behaviours. Because the reinforcing effects of T can induce preferences for specific environmental locations, T has the potential to alter behaviour through space use. In a monogamous species, this T pulse may contribute differently to space use in sexually naive (SN) and pair-bonded (PB) males: SN males may be more likely to explore new areas to set up a territory than PB males, which are more likely to defend an existing, established territory. In this study, we test for variation in T-driven space use by examining variation in the formation of conditioned place preferences (CPPs) in SN and PB male California mice. In the threechambered CPP apparatus, subcutaneous administrations of physiological levels of T were used to repeatedly condition SN and PB males to a side chamber, which is an unfamiliar/neutral environment. The final tests revealed that T-induced CPPs in the side chamber are developed in SN, but not PB males. This study fills a gap in our knowledge about plasticity in the rewarding nature of T pulses, based on past social experience.

show abstract

Environmental enrichment decreases intravenous self-administration of amphetamine in female and male rats

Abstract: These results suggest that environmental enrichment may serve as a protective factor for reducing amphetamine self-administration.

Cited by 242 publications

References 44 publications

Environmental enrichment effects on the neurobehavioral profile of selective outbred trait anxiety rats

Environmental enrichment effects on the neurobehavioral profile of selective outbred trait anxiety rats

Social Bonding Decreases the Rewarding Properties of Amphetamine through a Dopamine D1 Receptor-Mediated Mechanism

Pair bonding prevents reinforcing effects of testosterone in male California mice in an unfamiliar environment

Contact Info

Product

Resources

About