Environmental enrichment counteracts the effects of glioma in primary visual cortex

Castro, Maria Amalia Di; Garofalo, Stefano; Felice, Eleonora De; Meneghetti, Nicolò; Pietro, Erika Di; Mormino, Alessandro; Mazzoni, Annalisa; Caleo, Matteo; Maggi, Laura; Limatola, Cristina

doi:10.1016/j.nbd.2022.105894

Cited by 3 publications

(5 citation statements)

References 61 publications

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“…This systematic review also examined the effects of EE on tumor cell number, occurrence, inhibition, and the presence of tumors in mice. Consistent with the present findings, Di Castro et al (2021) reported a reduction in glioma tumor cell proliferation in mice exposed to EE [35]. This effect may be mediated by a decrease in GABAergic activity in the peritumoral area [36].…”

Section: Discussionsupporting

confidence: 92%

Environmental Enrichment in Cancer as a Possible Tool to Combat Tumor Development: A Systematic Review

Fernandes,

Lacerda,

Fidélis

et al. 2023

IJMS

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This systematic review aims to evaluate the influence of environmental enrichment (EE) on oncological factors in experimental studies involving various types of cancer models. A comprehensive search was conducted in three databases: PubMed (161 articles), Embase (335 articles), and Scopus (274 articles). Eligibility criteria were applied based on the PICOS strategy to minimize bias. Two independent researchers performed the searches, with a third participant resolving any discrepancies. The selected articles were analyzed, and data regarding sample characteristics and EE protocols were extracted. The outcomes focused solely on cancer and tumor-related parameters, including cancer type, description of the cancer model, angiogenesis, tumor occurrence, volume, weight, mice with tumors, and tumor inhibition rate. A total of 770 articles were identified across the three databases, with 12 studies meeting the inclusion criteria for this systematic review. The findings demonstrated that different EE protocols were effective in significantly reducing various aspects of tumor growth and development, such as angiogenesis, volume, weight, and the number of mice with tumors. Furthermore, EE enhanced the rate of tumor inhibition in mouse cancer models. This systematic review qualitatively demonstrates the impacts of EE protocols on multiple parameters associated with tumor growth and development, including angiogenesis, occurrence, volume, weight, and tumor incidence. Moreover, EE demonstrated the potential to increase the rate of tumor inhibition. These findings underscore the importance of EE as a valuable tool in the management of cancer.

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Section: Discussionsupporting

confidence: 92%

Environmental Enrichment in Cancer as a Possible Tool to Combat Tumor Development: A Systematic Review

Fernandes,

Lacerda,

Fidélis

et al. 2023

IJMS

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“…The underlying mechanisms of EE on social deficits or ASD may involve the improvement of neuronal functions, neurogenesis, and synaptic plasticity ( 8 , 57 , 58 ). The main molecular pathways of EE contribute to structural changes in the brain and enhance synaptic plasticity ( 14 ). This is primarily implicated in learning, memory, and mood regulation in different hippocampal regions (such as CA1, CA3, and dentate gyrus), cortex (mPFC), or other regions.…”

Section: Resultsmentioning

confidence: 99%

“…In addition to the prominent modulations of synaptic function, EE may play vital roles in managing autistic symptoms and pathology development through significant regulation of multiple targe-region proteins and signaling pathways that enhance neurological improvement in the brain. These pathways mainly involve neurogenesis and BDNF-related molecular pathways and pathological genes of ASD syndromes ( 8 – 11 , 13 , 14 ).…”

Section: Resultsmentioning

confidence: 99%

“…The hippocampus, an important region for learning and memory, has been a focal point, with scientists proposing interventions aiming at altering cell excitability and improving synaptic structure and morphology (7)(8)(9). Another avenue involves the regulation of neuroinflammation and neuron regeneration syndromes (8)(9)(10)(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

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Molecular insights into enriched environments and behavioral improvements in autism: a systematic review and meta-analysis

Li,

Lu,

Zhang

et al. 2024

Front. Psychiatry

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AimsAutism is a multifaceted developmental disorder of the nervous system, that necessitates novel therapeutic approaches beyond traditional medications and psychosomatic therapy, such as appropriate sensory integration training. This systematic mapping review aims to synthesize existing knowledge on enriching environmental interventions as an alternative avenue for improving autism, guiding future research and practice.MethodA comprehensive search using the terms ASD and Enriched Environment was conducted across PubMed, EMBASE, ISI, Cochrane, and OVID databases. Most of the literature included in this review was derived from animal model experiments, with a particular focus on assessing the effect of EE on autism-like behavior, along with related pathways and molecular mechanisms. Following extensive group discussion and screening, a total of 19 studies were included for analysis.ResultsEnriched environmental interventions exhibited the potential to induce both behavioral and biochemical changes, ameliorating autism-like behaviors in animal models. These improvements were attributed to the targeting of BDNF-related pathways, enhanced neurogenesis, and the regulation of glial inflammation.ConclusionThis paper underscores the positive impact of enriched environmental interventions on autism through a review of existing literature. The findings contribute to a deeper understanding of the underlying brain mechanisms associated with this intervention.

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“…[94] Analogous to olfactory stimulation, the proliferation of gliomas induced by visual deprivation is region-speci c. Recently, CS has been considered a cause of vision loss in glioma patients. [95,96] Despite observations of a relationship between visual deprivation, a speci c form of CS, and glioma in mouse models, there is currently no evidence to suggest a similar relationship in human glioma cell lines [Figure 2C]. Additionally, stress hormones also synergize this process and stimulate the proliferation of glioma cells.…”

Section: Sustaining Proliferative Signalingmentioning

confidence: 99%

Chronic stress as an emerging risk factor for the development and progression of glioma

Yi,

Lin,

She

et al. 2024

Chinese Medical Journal

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Gliomas tend to have a poor prognosis and are the most common primary malignant tumors of the central nervous system. Compared with patients with other cancers, glioma patients often suffer from increased levels of psychological stress, such as anxiety and fear. Chronic stress (CS) is thought to impact glioma profoundly. However, because of the complex mechanisms underlying CS and variability in individual tolerance, the role of CS in glioma remains unclear. This review suggests a new proposal to redivide the stress system into two parts. Neuronal activity is dominant upstream. Stress-signaling molecules produced by the neuroendocrine system are dominant downstream. We discuss the underlying molecular mechanisms by which CS impacts glioma. Potential pharmacological treatments are also summarized from the therapeutic perspective of CS.

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Environmental enrichment counteracts the effects of glioma in primary visual cortex

Cited by 3 publications

References 61 publications

Environmental Enrichment in Cancer as a Possible Tool to Combat Tumor Development: A Systematic Review

Environmental Enrichment in Cancer as a Possible Tool to Combat Tumor Development: A Systematic Review

Molecular insights into enriched environments and behavioral improvements in autism: a systematic review and meta-analysis

Chronic stress as an emerging risk factor for the development and progression of glioma

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