Environmental enrichment as a therapeutic avenue for anxiety in aged Wistar rats: Effect on cat odor exposition and GABAergic interneurons

Sampedro-Piquero, Patricia; Castilla‐Ortega, Estela; Zancada-Menendez, C.; Santín, Luis J.; Begega, Azucena

doi:10.1016/j.neuroscience.2016.05.032

Cited by 33 publications

(27 citation statements)

References 63 publications

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“…Consistently, our PV-TeLc mouse model presented with heightened anxiety, which we consider as a trait of the model. This is consistent with stress models of anxiety that have revealed a lowering of PV-GABA neurones in PFC of mice; this phenotype can be rescued by environmental enrichment (Sampedro-Piquero et al ., 2016). Although we have not mechanistically assessed the expression of this anxiety phenotype in PV-TeLc mice, our method has led to a lasting functional impairment of parvalbumin neurones in prefrontal regions (Murray et al ., 2015).…”

Section: Discussionsupporting

confidence: 89%

Parvalbumin-containing GABA cells and schizophrenia: experimental model based on targeted gene delivery through adeno-associated viruses

Wołoszynowska-Fraser¹,

Wulff

Riedel

2017

Behavioural Pharmacology

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Understanding the contribution of transmitter systems in behavioural pharmacology has a long tradition. Multiple techniques such as transmitter-specific lesions, and also localized administration of pharmacological toxins including agonists and antagonists of selected receptors have been applied. More recently, modern genetic tools have permitted cell-type selective interferences, for example by expression of light-sensitive channels followed by optogenetic stimulation in behaviourally meaningful settings or by engineered channels termed DREADDS that respond to peripherally administered drugs. We here took a similar approach and employed a Cre recombinase-dependent viral delivery system (adeno-associated virus) to express tetanus toxin light chain (TeLc) and thus, block neural transmission specifically in parvalbumin-positive (PV +) neurons of the limbic and infralimbic prefrontal circuitry. PV-TeLc cohorts presented with normal circadian activity as recorded in PhenoTyper home cages, but a reproducible increase in anxiety was extracted in both the open field and light–dark box. Interestingly, working memory assessed in a spontaneous alternation Y-maze task was impaired in PV-TeLc mice. We also recorded local field potentials from a separate cohort and found no global changes in brain activity, but found a behaviourally relevant lack of modulation in the gamma spectral band. These anomalies are reminiscent of endophenotypes of schizophrenia and appear to be critically dependent on GABAergic signalling through PV neurones. At the same time, these observations validate the use of viral vector delivery and its expression in Cre-lines as a useful tool for understanding the role of selective components of the brain in behaviour and the underpinning physiology.

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Section: Discussionsupporting

confidence: 89%

Parvalbumin-containing GABA cells and schizophrenia: experimental model based on targeted gene delivery through adeno-associated viruses

Wołoszynowska-Fraser¹,

Wulff

Riedel

2017

Behavioural Pharmacology

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“…Prior literature shows that the enriched environment enhances the responsiveness of cortical neurons to stress [296,297]. This is in line with my observation mentioned above where EE increases dendritic length, not branch points.…”

Section: Stress Significantly Increased the Number Of Spines On Seconsupporting

confidence: 90%

“…In my paradigm, an increase in dendritic length but a decrease in branch points of mPFC neurons was observed. Previous literature showed that the enriched environment enhanced the responsiveness of cortical neurons to stress [296,297].…”

Section: Impact Of Ee On Dendritic Morphology (Sa2)mentioning

confidence: 96%

Early life rearing of stressed animals in complex housing environment drives stress resilience in physiology, behavior and brain plasticity during adulthood

Nagarajan¹

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“…The exposure to only three weeks of EE was able to facilitate LTP as evaluated in hippocampal slices from twenty-one month-aged rats [96]. Finally, a two-month exposure to EE of nineteen month-aged rats potentiated gamma-aminobutyric acid (GABA)-ergic system [97].…”

Section: In Humansmentioning

confidence: 99%

Rethinking the Reserve with a Translational Approach: Novel Ideas on the Construct and the Interventions

Serra

Gelfo

Petrosini

et al. 2018

JAD

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The concept of brain, cognitive, and neural reserves has been introduced to account for the apparent discrepancies between neurological damage and clinical manifestations. However, these ideas are yet theoretical suggestions that are not completely assimilated in the clinical routine. The mechanisms of the reserves have been extensively studied in the neurodegenerative pathologies, first of all the Alzheimer's disease. Both human and animal studies addressed this topic by following two parallel pathways. Specific aim of the present review is to attempt to combine the suggestions derived from the two different research fields to deepen the knowledge about reserves. In fact, the achievement of a comprehensive theoretical framework on reserve mechanisms is an essential step to propose well-timed interventions tailored on the clinical characteristics of patients. The present review highlights the importance of addressing three main aspects: the definition of reserve proxy measures, the interaction between reserve level and therapeutic interventions, and the specific time-window of reserve efficacy.

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Environmental enrichment as a therapeutic avenue for anxiety in aged Wistar rats: Effect on cat odor exposition and GABAergic interneurons

Cited by 33 publications

References 63 publications

Parvalbumin-containing GABA cells and schizophrenia: experimental model based on targeted gene delivery through adeno-associated viruses

Parvalbumin-containing GABA cells and schizophrenia: experimental model based on targeted gene delivery through adeno-associated viruses

Early life rearing of stressed animals in complex housing environment drives stress resilience in physiology, behavior and brain plasticity during adulthood

Rethinking the Reserve with a Translational Approach: Novel Ideas on the Construct and the Interventions

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