Environmental Enrichment and Physical Exercise Attenuate the Depressive-Like Effects Induced by Social Isolation Stress in Rats

Brenes, Juan C.; Fornaguera, Jaime; Sequeira‐Cordero, Andrey

doi:10.3389/fphar.2020.00804

Cited by 37 publications

(34 citation statements)

References 125 publications

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“…Differences between samples underscore that exercise serves different functions for different groups. Exercise can be an important component of a healthy lifestyle and can help many individuals to effectively manage psychiatric symptoms regulation (Bernstein & McNally, 2017; Brenes et al, 2020; Centers for Disease Control and Prevention, 2018; Sampasa‐Kanyinga et al, 2020). A better understanding of why individuals engage in pathological exercise is key to effectively treating these behaviors in a way that does not sever the ability to engage in exercise and still promotes recovery.…”

Section: Discussionmentioning

confidence: 99%

“…Notably, for most individuals, exercise is not inherently pathological. Moreover, for individuals with symptoms of depression or anxiety, exercise can boost positive mood and mitigate difficulty with emotion regulation (Bernstein & McNally, 2017; Brenes, Fornaguera, & Sequeira‐Cordero, 2020; Sampasa‐Kanyinga et al, 2020). Accordingly, there is emerging evidence that exercise may be reintroduced earlier in the course of treatment for eating disorders than previously thought (Hay et al, 2018) and that it may be advantageous to do so (Dobinson, Cooper, & Quesnel, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Mapping features of pathological exercise using hierarchical‐dimensional modeling

Dreier

Coniglio

Selby

2020

Intl J Eating Disorders

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Objective Pathological exercise is common among those with eating disorders and has typically been characterized as excessive, compulsive, or compensatory in nature. Little is known about how pathological exercise is associated with other eating disorder behaviors or personality traits, or whether these associations differ between men and women. Method We used hierarchical dimensional modeling in three samples, including college women (N = 205), women with eating psychopathology (N = 268), and college men (N = 235), to examine latent associations between pathological exercise and eating disorder psychopathology, namely compulsivity, emotion regulation, and body dissatisfaction. Results Using Goldberg's (2006) “bass‐ackwards” method, we identified separate 10‐factor solutions (women) or an 11‐factor solution (men). A distinct muscle building factor arose in the three‐factor solution for men, and it also notably arose in the six‐ and eight‐factor solutions for community and college women, respectively, highlighting an important understudied motivation factor in both healthy and pathological exercise. Each solution accounted for 64.8% (college women), 51.9% (women with eating psychopathology), and 43.9% (college men) of the variance in excessive exercise, respectively. Discussion Findings indicate that pathological exercise is associated with different psychological traits (e.g., poor emotion regulation, compulsivity) across populations, and such differences may necessitate unique treatment approaches tailored accordingly.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mapping features of pathological exercise using hierarchical‐dimensional modeling

Dreier

Coniglio

Selby

2020

Intl J Eating Disorders

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“…In contrast, the red-to-blue colour gradient at the bottom represents how the distress levels decrease as much as the living environment becomes more natural. Text boxes in the middle summarize the commonalities between human and rats living contexts socially (e.g., temporarily housed in SH) or physically (e.g., given access to treadmill exercise) enriched, the adverse effects of SI are ameliorated or reversed (Biggio et al, 2019;Brenes et al, 2020). In other words, providing animals with the minimal substrates and materials promotes the emission of species-specific behaviours (e.g., foraging, forming social hierarchies, galloping, building nests and hideouts) capable of reducing the stress and impoverishment of captivity.…”

Section: Conditions Resemble Different Scenarios Of Humans Living In Urban Areasmentioning

confidence: 99%

The environmental enrichment model revisited: A translatable paradigm to study the stress of our modern lifestyle

Rojas-Carvajal

Sequeira‐Cordero

Brenes

2021

Eur J of Neuroscience

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In humans, stress represents a major vulnerability factor for developing different neuropsychiatric disorders such as depression, anxiety and schizophrenia. Consequently, different preclinical stress models have been developed for studying biobehavioural factors underlying psychopathology (Italia et al., 2020). For these models to be considered reliable and informative, multiple methodological, empirical, and theoretical criteria should be fulfilled to ensure that the obtained results

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“…Exercise: Frequent physical exercise has been accepted among people to improve the physical and emotional conditions. By designing several studies on sports achievements, it has demonstrated that neurotransmitters' functionality and brain plasticity have been modulated in socially isolated rodents (102). In several types of research, rats were forced to run on a treadmill, which was a stressful condition.…”

Section: Non-drug Treatmentsmentioning

confidence: 99%

Cognitive Consequences of Social Isolation During COVID-19: side effects and treatments

Taherizadeh¹,

Rahmani²,

Alidadi³

et al. 2021

Preprint

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Objective: During the COVID-19 pandemic, quarantine and staying at home is advised. The social relationship between people has become deficient, and human social isolation (SI) has become the consequence of this situation. It was shown that SI has made changes in hippocampal neuroplasticity, which will lead to poor cognitive function and behavioral abnormalities. There is a connection between SI, learning, and memory impairments. In addition, anxiety-like behavior and increased aggressive mood in long-term isolation have been revealed during the COVID-19 outbreak. Methods: Term searches was done in Google Scholar, Scopus, ScienceDirect, Web of Science and PubMed databases as well as hand searching in key resource journals from 1979–2020. Results: Studies have shown that some drug administrations may positively affect or even prevent social isolation consequences in animal models. These drug treatments have included opioid drugs, anti-depressants, Antioxidants, and herbal medications. In addition to drug interventions, there are non-drug treatments that include an enriched environment, regular exercise, and music. Conclusion: This manuscript aims to review improved cognitive impairments induced by SI during COVID-19.

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Environmental Enrichment and Physical Exercise Attenuate the Depressive-Like Effects Induced by Social Isolation Stress in Rats

Cited by 37 publications

References 125 publications

Mapping features of pathological exercise using hierarchical‐dimensional modeling

Mapping features of pathological exercise using hierarchical‐dimensional modeling

The environmental enrichment model revisited: A translatable paradigm to study the stress of our modern lifestyle

Cognitive Consequences of Social Isolation During COVID-19: side effects and treatments

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